Objective. To study clinical and pathophysiological relationship between pelvic organ prolapse (POP) and chronic pelvic pain syndrome (CPPS) in women, to identify pain development mechanisms, and to consider diagnostic and treatment tactics.

Materials and methods. Scientific publications for the past 10 years, clinical guidelines, and epidemiological data on POP and CPPS were analyzed for a given time frame. Pathophysiological mechanisms (nociceptive, neuropathic pain, central sensitization), POP-Q classification, diagnostic methods (ultrasound, MRI, urodynamics) were studied.

Results. Multifactorial POP-CPPS relationship was identified: chronic pain through mechanical (fascia stretching), compressive (nerve compression), neuroinflammatory mechanisms develop in 30-50% of women with prolapse. Kegel exercises and pessaries are effective in treating this condition, as well as the use of antidepressants (duloxetine, vortioxetine) when CPPS is combined with depressive disorders.

Conclusion. A multidisciplinary, personalized approach is required in the treatment of these conditions. Antidepressants are shown to be effective in treating central sensitization and psychoemotional disturbances accompanying CPPS in POP. 

Objective. To systematize data and analyze pathogenetic mechanisms of formation of intra-abdominal adhesions, possible consequences of formation of intra-abdominal adhesions, such as acute small bowel obstruction and female infertility, as well as the methodology of preventative measures for occurrence of peritoneal adhesions.

Materials and methods. A non-systematic analysis of scientific publications in PubMed, EMBASE, Web of Science, Google Scholar, Elibrary, and CyberLeninka for the period 1989–2025 was conducted, describing pathogenetic aspects of the adhesive process of the peritoneum; the role of adhesions in the development of conditions such as acute small bowel obstruction and female infertility, as well as options for preventing these conditions, were reviewed. A total of 46 original publications were selected.

Results. A key factor in the pathogenesis of peritoneal adhesions is a disruption of mesothelisation processes resulting from an imbalance of the peritoneal fibrinolytic system. This imbalance manifests itself with the inhibition of fibrinolysis as a result of a number of factors. These include extensive damage to the peritoneum, insufficient hemostasis, and intra-abdominal infection. The adhesive process of the peritoneum is the leading cause of the acute small bowel obstruction, accounting for 56% of cases. The adhesive process of the pelvic peritoneum occupies one of the leading positions in the etiology of female infertility. Up to 23% of women undergo treatment for infertility after abdominal surgery. Modification of surgical techniques does not significantly reduce adhesiogenesis. The most effective method of prevention of adhesive peritoneal disease is the use of anti-adhesion barriers.

Conclusion. Prevention of the adhesive process is a critical area of healthcare, reducing the frequency of complications and mortality in conditions associated with the formation of adhesions. Development of new anti-adhesion barriers based on the pathogenetic mechanisms of adhesion formation is a promising direction in the prevention of the adhesive process.

Objective. To systematize current trends in the application of AI in diagnostic radiology, to analyze the evidence base, clinical efficacy, and limitations of real implementation, as well as to assess regulatory, ethical, and organizational and economic factors.

Materials and methods. A descriptive analytical review of publications indexed in the PubMed/MEDLINE and RSCI databases for the period of 2020–2026 was conducted, analyzing the primary directions of AI application in radiology.

Results. This review presents an analysis of the current state of AI technology application in diagnostic radiology. The main directions of the clinical use of AI systems are examined: detection and classification of paroplasms, quantitative assessment of focal lesions, medical image reconstruction, and generation of structured reports. The evidence base of AI solutions efficacy was analyzed taking into account external validation results. Regulatory requirements, ethical issues, and organizational aspects of integrating AI into radiological practice were discussed. Special attention was paid to the limitations of existing studies and the future prospects for the development of this field.

Conclusion. AI systems demonstrate significant potential for enhancing the quality and efficiency of diagnostic radiology; however, their clinical value is determined not only by accuracy metrics, but also by their ability to perform reliably in real-world clinical settings, and their compliance with regulatory requirements.

Objective. Analysis of the prevalence, clinical features, and microbiological data of urinary tract infections (UTI) in patients with liver cirrhosis (LC).

Materials and methods. A prospective observational study was conducted on 338 hospitalized patients with liver cirrhosis aged 55.00 (45.00; 63.00) years old, including 189 (55.92%) men and 149 (44.08%) women, with class A – 78 (23.08%), class B – 118 (34.91%), and class C – 142 (42.01%) patients. The study included a microbiological examination of 1,056 urine samples for microbiota and antibiotic sensitivity over a 48-hour period from admission to the hospital organization and after 48 hours of hospitalization. Statistical data processing was performed in the R programming environment. The significance level α is taken to be 0.05. The study was registered in Clinicaltrials.gov (NCT05335213).

Results. The incidence of urinary tract infections is 37.87%, and asymptomatic bacteriuria is 23.96% in hospitalized patients with liver cirrhosis. Urinary tract infections are more commonly diagnosed in women (57.81% vs. 42.19%, p<0.001), in patients with decompensated cirrhosis (p<0.001), and those with a history of liver cirrhosis less than 10 years (p<0.001). Urinary tract infections occur with infections of other localizations in 45.31% of cases. Urinary tract infections with systemic manifestations (79.69%), health-care associated infections (72.66%), catheter-associated infections (56.25%), risk factors (94.5%), and complications (88.94%) prevail in patients with liver cirrhosis. 70% of patients with liver cirrhosis with urinary tract infections had a fatal outcome of the disease within 45 months of follow–up, which is significantly higher than in patients without urinary tract infections – 34% (p<0.001). For patients with urinary tract infection, the immediate risk of death is more than 4 times higher (HR=4.32; 95% CI: 2.88–6.50; p<0.001) compared to individuals without infection. Mixed microbiota of urine was identified in 59 (46.09%) patients. The most common uropathogens were Escherichia coli (36.72%), Enterococcus feacalis (32.81%), and Klebsiella pneumoniae (27.34%). In more than 85% of patients, the isolated strains of Acinetobacter baumanii, Serratia marcencens, Staphylococcus spp., Proteus mirabilis, and Klebsiella pneumoniae were characterized by multiple or extreme resistance to antibacterial drugs.

Conclusion. Urinary tract infections in hospitalized patients with liver cirrhosis have a high prevalence, in most cases have a complicated course, are health-care associated, are associated with an unfavorable prognosis, are characterized by a polymicrobial spectrum of pathogens that belongs to the Pseudomonadota and Bacillota department. The choice of antibacterial drugs should be based on local resistance and be optimized based on the results of drug sensitivity.

Objective. Evaluate the risk of textile vascular prosthesis infection in patients with peripheral artery disease (PAD) after reconstruction in the aortoiliac-femoral position.

Materials and methods. At the first stage, a retrospective analysis of the medical history of 317 patients who had tissue vascular prostheses implanted without antibacterial treatment during reconstructive operations on the aortoilioemoral segment was performed.
The operations were carried out at the Gomel Regional Clinical Cardiological Center. The patients were monitored for up to five years. At the second stage, patients who were scheduled for implantation of a woven prosthesis and had grade 4 chronic arterial insufficiency with purulent necrotic lesions of the feet and/or shins according to the Pokrovsky classification were selected.

Results. In all cases of prosthetic infection (100%), clinical signs were observed: from local inflammatory foci to systemic reactions caused by bacteria of the genus Staphylococcus. Thus, isolated paraprosthetic abscess occurred only once (5%), a combination of abscess and lymphorrhea – in eight cases (40%), and a combination of abscess, lymphorrhea and septic process – in two cases (10%). In eight cases (40%), a paraprosthetic hematoma with signs of infection was diagnosed, accompanied by arrosive hemorrhage.

Conclusions. In 100% of cases in patients with a high risk of infection, the textile vascular prosthesis was accompanied by characteristic local changes below the inguinal crease on the side of the affected lower limb, as well as the detection of Staphylococcus bacteria.

Objective. To study characteristics of pain syndrome, emotional disorders, and quality of life indicators in patients with paraproteinemic polyneuropathy (PPPNP) in multiple myeloma (MM) before the start of chemotherapy courses.

Materials and methods. A total of 102 patients with multiple myeloma were examined prior to the initiation of chemotherapy courses. Based on symptoms assessment, neurological status, and the findings of stimulation electroneuromyography (EMG) of the upper and lower extremities, two patient subgroups were formed: with symptomatic paraproteinemic polyneuropathy and without it. The results of patient surveys were studied in each subgroup using questionnaires for diagnosing the intensity and nature of pain syndrome (VAS, DN4, CSI), live quality assessment (EORTC-QLQCIPN20, SF-36), and the presence of anxiety-depressive disorders (the Spielberger State-Trait Anxiety Inventory and the Beck Depression Inventory) followed by comparison of results between subgroups.

Results. Symptomatic paraproteinemic polyneuropathy was identified in 29 patients (28,4%; 95% CI (19,7-37,2)), whilst a significant correlation (p<0.05) was found between the severity of subjective and objective sensory and motor symptoms of paraproteinemic polyneuropathy and the quantitative parameters recorded of the EMG. In patients with symptomatic paraproteinemic polyneuropathy, the mental component of health and the average quality of life score were significantly lower (p<0.05), while the severity of the neuropathic and dysfunctional components of pain, as well as limb pain intensity, were significantly higher (p<0.05) compared to the remaining patients without the symptomatic form of paraproteinemic polyneuropathy.

Conclusion. Subject to the impact of symptomatic paraproteinemic polyneuropathy on the severity of neuropathic and dysfunctional pain components, as well as on the patients’ quality of life with multiple myeloma, its early clinical and instrumental diagnosis is essential with regard to a multidisciplinary approach to enhance the effectiveness of treatment for the underlying disease and its complications.

Objective. To analyze and systematize data on the treatment results, and morphological changes in neoplasms (N) in association with the use of neoadjuvant polychemotherapy (NPCT) in a complex treatment of gastric cancer (GC).

Materials and methods. Original publications containing information on the use of NPCT in the complex treatment of GC, pathomorphological changes (PC) of neoplasms in the course of this treatment, deposited in the resources of PubMed and the information portal eLIBRARY.RU, were studied. Olympus CX41 RF microscope, Olympus SC20 digital camera, Statistica 10.0 software package, Pearson criterion, Mann Whitney criterion, paired t-test were used.

Results. The most important aspects concerning the use of NPCT in complex treatment of GC were highlighted, and the treatment results and morphological changes of neoplasms in patients with this pathology in the course of this treatment were analyzed.

Conclusion. Currently, in the treatment of resectable GC, preference should be given to a combination of NPCT followed by radical surgery. The level of N pathomorphism and changes in neutrophil-lymphocyte ratio (NRL) might be promising criteria for assessing the effectiveness of the chosen chemotherapy (CT) regimen, as well as its subsequent use in the adjuvant setting.

Objective: To study the social, hereditary, clinical, and psychological differences in the course of alcohol addiction syndrome (AAS) in men and women to substantiate additional examination and treatment methods.

Materials and methods: 123 patients with AAS of those 99 men and 24 women, were examined at the Republican Scientific Practical Center (RSPC) for Mental Health in Minsk in 2024.

Results: Men were more likely to be unemployed than women (40 (40.4%) and 4 (16.7%) accordingly, p=0.029). Employed men had a longer work history than unemployed ones (employed men – 20.0 [10.0, 22.0] years old, unemployed men – 10.0 [5.0, 20.0] years old, p=0.024). Women were characterized by a higher incidence of second-degree blood relatives (men – 53 (53.5%), women – 21 (87.5%), p=0.005). Maternal alcoholism was more common among women (men – 8 (8.1%), women – 7 (29.2%), p=0.010). Women differed with preference for mildly (beer, gin and tonic) and medium (wine) alcoholic drinks in the early stages of the disease (p<0.05) and a reduced daily tolerance to alcohol (p<0.05). Women were common with higher incidence of accentuated personality traits, especially emotive types (men – 58 (59.8%), women – 20 (83.3%), p=0.031).

Conclusion. The differences found do not allow to separate “male” or “female” alcoholism into separate nosological categories, but they significantly influence the choice of examination and treatment methods

Objective. To establish basic mechanisms of early relapses in therapeutic remission in alcohol addiction (AD).

Materials and methods. A comprehensive (clinical, experimental and psychological, and statistical) comparative study was conducted in 81 patients with AD at the stage of therapeutic remission (including 39 patients in high-quality remission (HQR) and 42 patients with relapses in therapeutic remission up to 6 months of abstinence from alcohol) aged from 27 to 55 (40.2±7.2) years old. 

Results. It was established that according to all biopsychosocial risk factors for AD relapse, patients with early relapses in therapeutic remission differed from those in high-quality remission only in psychological characteristics: decreased level of disease awareness (0.78±0.67 vs. 0.04± 0.21 points, p<0.01); noncompliance (2.64±0.56 vs. 0.46±0.85, p<0.01); experiences of boredom (1.25±1.12 vs. 0.13±0.63 points, p<0.01), and a positive attitude to alcohol-related situations (1,58±0,94 vs. 0.72± 0.75 points, p<0.01).

Conclusion. Patients with early relapses of therapeutic remission from AD compared to HQR ones, in the absence of clinical signs of the disease in both groups, were characterized by persistent alcohol addiction at the personal level, which was manifested by their low understanding of the disease, experiences of boredom without alcohol, and occurrence of a primary positive emotional reaction when exposed to conditioned reflex signals associated with alcohol.

Objective. To clarify clinical characteristics, time parameters and associated symptoms of persistent post-stroke headache (PSPH).

Materials and methods. A cohort study was conducted at the neurological and rehabilitation departments of the Gomel University Clinic – Regional Hospital for Disabled Veterans of the Great Patriotic War for the period from 2018 to 2024. The study included three groups: a main group of patients with post-stroke headache, a comparison group for individuals with chronic cerebral ischemia (CCI), and a retrospective follow-up survey group. The main group included 45 patients in the recovery period of acute cerebrovascular accident (ACVA) with PDPH (mean age 61.1±13.5 years old; 40 with cerebral infarction (CMI), 5 with intracerebral hemorrhage (ICH). The comparison group consisted of 36 patients with CCI. We used a visual analog scale (VAS), Douleur Neuropathique4 (DN4) scale, PainDetect, McGill questionnaire, central sensitization scale, Beck and Spielberger-Khanin questionnaires to describe the pain syndrome. The follow-up group (n=70) was surveyed using a telephone interview. Statistical processing was performed using the Statistica 12.0 software package.

Results. Patients with CCI, compared to those with PDPH, have higher values of the McGill Pain Questionnaire – number index of selected descriptors of the sensory scale (p=0.03), the evaluative scale (p= 0.016), as well as the central sensitization questionnaire (p<0.0005) and Spielberger’s personal anxiety (p=0.019). In case of ICH, the average and severe pain over the last 4 weeks reached 10 points on the VAS, which is significantly higher than with IHM (p=0.005 and p=0.001). PDPH debuted in the first 3 months in 92.9% of patients; constant pain was recorded in 21.4%. Sensory symptoms (numbness, paresthesia) occurred in 21.2%, sleep disturbance – in 19.2%.

Conclusion. PDPH represents a heterogeneous condition with various pathophysiological occurance mechanisms. A differentiated approach to diagnosis and treatment based on the temporal, qualitative, and sensory characteristics of pain will improve rehabilitation outcomes and quality of life for this group of patients.

Objective. To study the dynamics of changes in cognitive status in combination with spectroscopy data in patients with the post-COVID-19 condition.

Materials and methods. Study design: prospective, cohort, completed; study period: 2024-2025. 28 patients (10 men and 18 women; median age – 48 [47,5; 55,5] years old) with clinical manifestations of the condition after COVID-19 were examined. A control group consisted of 12 healthy individuals (median age – 43 [36;48] years old, 7 women and 5 men). All subjects filled a checklist of post-COVID-19 conditions twice (with inclusion in the study and 6-9 months later), the Mini-Mental State Examination (MMSE), the A.M. Veyn autonomic questionnaire, and the Spielberger-Khanin questionnaire. To objectify the disorders, all the examined subjects underwent two magnetic resonance brain tomography (MRI) scans in a 3D pulse sequence with a slice thickness of 1 mm and a square matrix in various scanning planes, as well as multivoxel spectroscopy. A mathematical analysis was performed using the STATISTICA 10.0 software package. The images were generated using RStudio 2026.01.1.

Results. In patients with the condition after COVID-19, no improvement in functional status was detected upon repeated examination according to the data of filling out the checklist (9 [6;12] points and 9 [6;12] points, p=0.98) MMSE (28 [26.5; 29] points and 28 [27; 29] points, p=0.24), the A.M.Wein questionnaire (33 [27.5; 52] points and repeated 33.5 [22.5; 51] points, p=0.84), personal (40 [37;44] and repeated 45 [41;45], p=1.0) and reactive anxiety (50 [47;53] and again 49 [47;58], p=0.72). Distribution of patients by severity subgroups revealed a deterioration in subjective neurological status (χ2=11.1759, df=4, p=0,24662). The data from MRI spectroscopy did not reveal any significant dynamics in the indicators, while the inter-zone differences were smoothed out based on the analysis of the N-acetylaspartate/creatinine ratio in the anterior regions of the precentral gyrus on the left (p=0.93) and right (p=0.63), and the choline/creatinine ratio in the anterior regions of the cingulate gyrus on the right (p=0.138).

Conclusion. In patients with post-COVID-19 conditions during dynamic observation an aggravation of the subjective neurological status in the absence of positive dynamics of cognitive and vegetative status indicators and data from brain MRI spectroscopy was revealed.

Objective. To evaluate efficency of applying adjuvant multimodal analgesia (MMA) in urological patients in the early postoperative period.

Materials and methods. The study included 80 patients with planned surgical interventions of transvesical or transurethral adenomectomy, transurethral resection of the bladder formation, who underwent surgical treatment at the Gomel City Clinical Hospital No. 2. The average age of patients was 59.8±10.6 years old for males (n=74) and the average age of 6 female patients was 57.4±7.2. The study period included 2023-2025. The study group included 40 people. The surgical intervention was performed on a planned basis in urological patients in remission without concomitant pathology or with somatic concomitant pathology in the compensation stage without disruption of the internal organs, and without signs of acute or chronic infection. The study group included 40 individuals. The patients of this group received spinal anesthesia and intravenous ketamine bolus administration prior to the surgical incision following MMA nonsteroidal anti-inflammatory drugs (NAID). The comparison group included 40 patients. This group received spinal anesthesia without additional ketamine administration on an incision, and without MMA in postoperative period. The patients were matched for gender, weight and height, nosological, and functional characteristics.

Results. In this prospective cohort study, it was possible to achieve a 25% reduction in the daily dose of opioid analgesics (promedol) with the use of ketamine adjuvant at p<0.05, which reduces pain sensitivity according to the visual analogue scale (VAS) by 43% after 12 hours after operative treatment, and achieve a complete analgesia after 24 hours against the background of spinal anesthesia in comparison with the group where ketamine was not used.

Conclusion. Administration of the preventive analgesia with ketamine in the perioperative period with selected drug dosages during the day after surgery is an effective method of analgesia in elderly patients with urological problems.

Objective. To provide a clinical and morphological description of a case of splenic hemangioendothelioma with liver metastases, and to analyze its pathomorphological and immunohistochemical characteristics in accordance with current diagnostic and differential diagnostic criteria.

Materials and methods. A case of epithelioid hemangioendothelioma (EHE) of the spleen with metastatic liver involvement in a 73‐year‐old woman admitted to the hospital with complaints of left upper quadrant pain, abdominal distension, and jaundice was presented.

Results. Post‐mortem examination revealed a massive splenic tumor measuring 15×12×10 cm, with widespread metastases to the liver. Histologically, the tumor was characterized with a biphasic pattern, featuring solid nests of epithelioid cells and anastomosing vascular channels. Immunohistochemical analysis demonstrated diffuse positive expression of CD31, CD34, and ERG, confirming the endothelial nature of the tumor, with a Ki‐67 proliferation index of 10–15%.

Conclusion. This clinical observation demonstrates typical pathomorphological features of epithelioid hemangioendothelioma of the spleen and underscores the importance of comprehensive immunohistochemical analysis for the differential diagnosis of rare vascular tumors. The late diagnosis at the stage of disseminated disease reflects the non‐specific nature of clinical manifestations and explains the poor prognosis. This case study contributes significantly to the Russian‐language medical literature, given the extreme rarity of this pathology.

Protected percutaneous coronary intervention (PCI) of the left main coronary artery (LMCA) remains a technically challenging procedure associated with a high risk of hemodynamic instability during balloon occlusion, particularly in patients with multivessel coronary artery disease and reduced left ventricular function. The use of mechanical circulatory support (MCS) devices enhances the safety of such interventions in high-risk patients. Among available platforms, the PulseCath iVAC 2L is a pulsatile transaortic left ventricular pump compatible with standard intra-aortic balloon pump consoles, providing active ventricular unloading while maintaining physiological pulsatile systemic perfusion [1, 2]. This article presents a clinical case of protected LMCA stenting using the iVAC 2L device in a 64-year-old female patient with nonQ anterior wall myocardial infarction and complex multivessel coronary artery disease, including critical stenosis of the distal LMCA with involvement of the left anterior descending (LAD) and left circumflex (LCx) artery ostia. Over the patient’s categorical refusal of coronary artery bypass grafting, a protected PCI strategy under mechanical hemodynamic support was selected. The iVAC 2L device was deployed via the right common femoral artery for 40 minutes in ECG-synchronized mode, while coronary access was obtained via the right radial artery. Following sequential predilatation, a 3.0×34 mm stent was implanted in the distal LMCA/proximal LAD segment using proximal optimization technique (POT) within a provisional stenting strategy. An optimal angiographic result was achieved, demonstrating TIMI (Thrombolysis in Myocardial Infarction) grade 3 flow, no residual stenosis, and no intraprocedural complications. The patient was discharged on day 14 in satisfactory condition on dual antiplatelet therapy. This case demonstrates the feasibility and safety of using the iVAC 2L for LMCA stenting as a revascularization option in high-risk patients.

Objective. To analyze the current state and prospects for the application of Synthetic Patient technology in medical education, and to develop the Surgical-Case-Simulator web application.

Materials and methods. A systematic search of research publications was conducted in PubMed, Scopus, and Web of Science databases for the period of 2010–2025 using keywords: synthetic patients, virtual patients, medical education, artificial intelligence, communication skills training. 50 most relevant studies analyzed formed the basis for the original development of the Surgical-Case-Simulator web application.

Results. Synthetic patient technology has evolved from simple game-based simulations to sophisticated systems based on generative artificial intelligence (AI). Modern platforms using large language models, voice cloning, and realistic avatars enable the creation of scalable solutions for the training process. Studies show that the use of virtual patients increases learners’ confidence in further communication with real patients, and improves standardized assessment of communication skills. The emergence of open-source developments such as Surgical-Case-Simulator demonstrates the accessibility and practical feasibility of AI simulators for a wide range of educational institutions.

Conclusion. Synthetic patients represent a promising direction in medical education. The optimal approach is their integration into existing programs as a complement to traditional methods. Further research is needed for evaluation of comparative efficacy, and solving ethical issues of implementing AI technologies.

Objective. To evaluate efficiency of intra-articular administration of the medical device “Plasma enriched with soluble platelet factors, autologous” (MD “PRP autologous”, registration number Mn-7.1198917-2009) in patients with knee osteoarthritis.

Materials and methods. Patients with knee osteoarthritis (KA) received treatment with three intra-articular injections of MD “PRP autologous”. Clinical and functional status of patients was assessed using the visual analogue scale (VAS), WOMAC, Likert, and Leken scales. The levels of pro-inflammatory (IL-1, IL-6) and anti-inflammatory (IL-4, IL-10) interleukins were determined in 2 weeks, 4 weeks, and 6 months after the start of treatment. Ultrasound examination of the knee joints was performed before the start of treatment and 6 months after the administration of MD “PRP autologous”.

Results. A statistically significant reduction in pain syndrome (WAS scale) was observed between the baseline level before treatment and 4-week and 6-month follow-up periods. A statistically significant improvement in the functional status of patients’ knee joints on the WOMAC scale was noted between baseline and 4 weeks, on the Leken scale, a decrease in this indicator between baseline and 4 weeks and between baseline and 6 months, and a decrease in the Likert scale between the baseline and 4 weeks was noted. The anti-inflammatory effect was expressed in a statistically significant decrease in IL-6 and IL-10 levels 6 months after the start of treatment, and their levels at the intermediate stages of treatment at 2 weeks and 4 weeks. Stabilization of the thickness of the articular cartilage in various sections of the femur and tibia after 6 months was established in the range from 64.71% to 88.24%.

Conclusion. The conducted study showed that intra-articular administration of MD “PRP autologous” led to a reduction in pain syndrome, improvement in the functional state of the knee joint, anti-inflammatory effect, and stabilization of joint cartilage thickness. The data obtained indicate a positive effect of treatment with MD “PRP autologous” in patients with KA of the knee joints.

Objective. To study global experience of using equipment and software for working with DICOM (Digital Imaging and Communications in Medicine) files in the educational process at the Department of Human Anatomy. To substantiate the concept of creating a specialized laboratory for digital topographic anatomy, radioanatomy, and 3D printing to improve the quality of medical personnel training and stimulate research activities.

Materials and methods. An analysis of scientific and methodological literature for the period from 2014 to 2026 was conducted (12 of the most relevant sources were selected). An anonymous, voluntary survey of 127 firstto sixth-year medical students (59.8% in their third year) was conducted using an original author questionnaire (17 questions). Methods of systems analysis and pedagogical modeling were applied for literature reviewing and survey data processing.

Results. Key trends in the development of medical education were identified: use of digital technologies, 3D printing, VR technologies, and a competency-based approach to teaching. A high level of student interest in using digital technologies (90,5%) was confirmed, despite a lack of practical skills in working with medical images (computer tomography (KT), magnetic resonance imaging (MRI)). A laboratory concept was developed, including hardware and software, information and archival, and learning and teaching modules. The expected results and economic feasibility for creating the laboratory of digital anatomy, X-ray anatomy and 3D printing were analyzed.

Conclusion. A shortage of practical skills in working with medical images was identified (only 15% of respondents rate their readiness to interpret CT and MRI data as confident). At the same time, 90,5% expressed their interest in using digital technologies. Implementation of the laboratory concept will create an innovative educational environment, develop professional competencies of future medical specialists, and ensure continuity in the study of anatomy and X-ray anatomy at clinical departments.