Multiple myelomes (MM) is the B-cellular tumor which is characterized by accumulation of plasmatic cells in bone morrow.

The information about the modern medical treatment of the acute coronary syndrome was presented in the fours parts of this review.

In article the review of modern representations dedicated problems etyopathogenesis, clinic, diagnostics and treatment mycotic affection external and middle ear.

In the article authors produced and generalized data which were accumulated during the last few years about constitutional peculiarities of an individual as a genetic marker of predisposition to different kinds of diseases including those that have hereditary basis. The analysis was done to learn about possibility of using these markers for formation of high-risk group with the purpose of prenosological diagnostics of particular diseases.

The study of acetylated polymorphism does not lose its actuality not only because plenty of remedies and carcinogenic substances metabolize by means of acetylization reactions, but also because much success has been achieved in the understanding of molecular bases of acetylation. Just these genetically due variations of remedy metabolism are one of the causes of individual peculiarities of pharmacotherapeutic effects. A man has two discovered genes, responsible for the activities of N-acetyltransferase enzyme - NAT1 и NAT2. The research has shown, that some alleles of these genes influence individual sensitivity to single illnesses.

Herbal preparations from Milk Thistle possess documented hepatoprotective properties. Nowadays the increase of interest to this herbal drug is connected with the prevalence of different forms of liver pathology and with the discovery of new properties of its active components. This review contains information on pharmacology, mechanism of action, efficiency of Milk Thistle preparations applications in liver diseases and demonstrates possibilities of their using in other pathological states.

The given bioelectret properties of blood of clinical groups sick by ischemic heart disease and control group are analysed. The assumption is confirmed, that change bioelectret properties of blood can be considered, how a nonspecific marker of a degree of pathological changes of cardiovascular system, including, and in conditions of destabilization of hemovascular homeostasis. On size of a residual charge it was possible to differentiate clinical groups on a degree of weight of the basic disease. Patients with ischemic heart disease have higher, than conditionally healthy, size of a residual charge which even more increases with increase of a functional class of a stable stenocardia of a pressure, and also at presence of accompanying pathologies, such as an arterial hypertension.

Bacterial infections considerably complicate of cirrhosis current, are principal causes of death of such patients. As a rule, infectious complications develop at persons with decompensated cirrhosis. In the medical literature the term «spontaneous bacterial peritonitis» at cirrhosis is often mentioned. This typical infectious complication of cirrhosis about in 25 % of cases is a cause of death of patients. It is connected with absence of the clinically apparent signs. Nonspecific symptoms - abdominal pain, fever, leukocytosis, increase of hepatic encephalopathy. SBP may be asymptomatic or there may be minor symptoms only. Late diagnosis of this complication explains high lethality at SBP. The basic method of diagnostics of SBP- analysis of ascitic fluid. The manual count of polymorphonuclear neutrophils by the traditional hematological method is laborious and, in many instances subjective. In the literature there are developed new methods of diagnostics of SBP. They allow to accelerate search of infectious process. The diagnosis timely improves the prognosis of patients with SBP.

In article results of interrogation 71 patients with a primary cancer of a face skin (T₁N₀M₀) it is offered to them to choose optimum from their point of view a way of treatment are published. According to patients, following parametres of medical process are important: antineoplastic efficiency, duration of treatment, the treatment organisation, aesthetic result, painful sensations. 67,6 % interviewed are inclined to trust in a choice of the doctor in the presence of alternative ways of treatment.

The worsening of endothelium dependent vasodilation, antioxidate protection and increasing aggregation of platelets at children and adolescens with vegetative dysfunction and risk factors of atherosclerosis (n = 136) in contrast with given factors in the group healthy children and teenagers (n = 190) were revealed. The elimination of changing risk factors of atherosclerosis (smoking, stress, hypodynamia, atherogenic diet, etc) alongside traditional treatment with 12 monthes of rehabilitation the ill children the studing parameters at low and average level of the risk factors of atherosclerosis normalized and only partial сhanged at high level one.

In this article were generalized facts about structure and morphological congenital features of kidneys dysplasia at aborted fetuses and first ear life children, died in 2006-2008 year. A Nozological structure congenital malformation of kidneys in Gomel region was analyzed.

A multifactorial risk pattern of periodontitis has been recognized, where in addition to host and environmental factors a pathogenic microbiota plays a primary role. Of the more than 500 bacterial species that have been identified from subgingival plaque, only a small number have been suggested to play a causal role in the pathogenesis of destructive periodontal diseases. This paper reviews the importance of these pathogens in the initiation and/or progression of periodontal diseases.

The results of scientific research concerning fluorescence of patients teeth (of junior and older age groups) are given in the article. Also there is a data concerning filling materials of different manufactures and their comparative characteristic.

Today the use of composites and photopolymerization reactors has become widely spread in stomatologic practice. They are irreplaceable while making qualitative and aesthetic restorations of teeth. Photopolymerization is a complex and ambiguous process, which is proved by existance of many factors influencing it. And this, in it’s turn, demands closer and thought over approach, as well as development and introduction of algorithms of use of photopolymerization reactors considering the type of the applied device and clinical situation.

A survey is presented the thiazide diuretics and their current place in the treatment of arterial hypertension. Mechanism of action, pharmacokinetics, side effect are reviewed. Optimal dosage, proper use in hypertension is described.

The article deals with the specific features of the nervous system in patients with 1 type diabetes millitentis and their connection with somatotype. The studying of such psychosomatic interconnections may help to understand the ethiology, pathogenesis and clinical course variants of the disease apart from the traditional approach.

We studied serum immunoglobulin A,M,G levels in 68 HIV-positive, 36 HIV-negative pregnant women and 31 HIV-positive non-pregnant women by enzyme linked immunosorbent assay. HIV-infection has negative influence on humoral immunity during pregnancy.

According to the data of the most authors, the number of patients with detected adrenal gland incidentalom proliferates in geometric progression every year. In the article the present-day methods of diagnostics, differentially diagnostic algorithms, tactic approaches and also the methods of treatment for accidentally detected tumor of adrenal gland have been given.

One of the basic links pathogenesis of MM is osteolytic defeats of a bone fabric. At the heart of this process lies inhibition osteoblast activity and increased osteoclast activity. At 80 % of patients decrease in mineral density of a bone fabric in a combination with individual or plural bone lesions and pathological fractures takes place. Late diagnostics low mineral density can lead to development of the driven crises of the vertebras, raised mobility of disks with development of a compression of a spinal cord and neurologic semiology. For MM spontaneous easily arising crises of bones are characteristic, therefore frequently patients from MM arrive in hematological branches after inspection and treatment at the traumatologist. In the program of treatment of MM the special role belongs to appointment of preparations from group bisphosphonates. Patients from MM should receive cyclic long (not less than 2th years) preventive treatment bisphosphonates for the prevention of pathological crises, in independence of presence or absence of an osteoporosis.

The work that has been carried out describes for the first time the hereditary caused breast cancer cases in Gomel region of Belarus, having defined a spectrum and frequencies of the most significant genetic factors underlying the given pathology. After the molecular-genetic testing of 667 primary breast cancer cases it was shown that out of eight BRCA1/2 gene mutations that are widely spread in Eastern Europe there are only five ones in Gomel region of Belarus with various frequencies - 185delAG, 300T>G, 4153delA, 5382insC and 6174delT. The 2274insA, 3819del5 and 3875del4 mutations were not found in the studied group. The 5382insC mutation was found to be the predominant one, which has made 80 % of all the detected mutations. Total mutation frequency in nonselective sampling taking into consideration the standardized indicators of age structure has made 7,9 %. It was found out, that family anamnesis is the most significant criterion from the point of view of probability estimation of BRCA1/2 mutations in genotype. In the united subgroup of patients with any of the basic signs of family cancer and their combinations, the share of mutations has made 24,4 %.

Results of research of dependence of development and current of a multiple sclerosis from density of radioactive pollution and size of settlement are stated. It is established (with reliability 0,68), that in a zone with radioactive pollution from above 5 Ku/км² heavier current of disease expressed in prevalence of progredient forms is observed. It is shown, that there is statistically authentic tendency of increase of weight of current of disease in cities with the population from 10 up to 50 thousand person.

In the article, there is a survey of modern literature as for problem of etiology, classification, pathogenesis and major clinical manifestations of long QT syndrome in children. The electrocardiographyc criteria for diagnosis of the syndrome, features of syncopic states and the possible ways of life-threatening arrhythmias prophylaxis in children are discussed.

The correlation of cell density and morphology of cornea endothelium with glaucoma stage, intraocular pressure, сentral corneal thickness, and retinal nerve fiber layer was defined among patients with glaucoma. Cell polymorphism level and their density varied depending on medical treatment being exposed to the greatest transformations after penetrating surgery of glaucoma.

The given changes of structurally functional parameters of a myocardium left ventricular in clinical groups of patients with chronic ischemic illness of heart are analysed. The analysis has allowed to reveal statistically significant distinctions on the majority of the parameters describing structurally functional reorganization of a myocardium left ventricular at patients with chronic ischemic illness of heart. The given researches have shown presence of dependence between size of a residual charge and parameters echocardiography in clinical groups of patients with chronic ischemic illness of heart. The assumption is confirmed, that change bioelectret properties of blood can be considered, how a nonspecific marker of a degree of pathological changes of cardiovascular system, including, and in conditions of structurally functional reorganization of a myocardium.

In present study we investigated effect of amino acids composition of BCAA, taurine and BCAA, taurine and tryptophan on the liver amino acids pool of rats under chronic alcohol intoxication. Chronic ethanol intoxication led to increase levels of glutamate, asparagines, glycine, b-alanine, thirozine, and decrease level of alanine in the liver of rats. Administration of composition of BCAA, taurine and tryptophan was found to normalize the levels of aromatic amino acids, glutamate and alanine.

The effect of phytoadaptogens (currant, great bilberry, bird cherry and some other) on the¹³⁷Cs elimination from rats’ bodies was under study. It was proved that pectins contained in phytoadaptogens were responsible for¹³⁷Cs elimination from rats’ bodies. The applied phytoadaptogens were subdivided into two categories. Some of them accelerated¹³⁷Cs elimination by 9-28 %, the other retarded this process (bird cherry decreased the rate of elimination by 11 %). The half-life of elimination was determined for all phytoadaptogens. The obtained data can be applied to predict the effect of phytoadaptogens on the¹³⁷Cs elimination from rats’ bodies.

This article analyses psychological factors, determining the development of ischemic heart disease, it also singles out the mechanisms of the influence of mental sphere on the genesis and development of the disease, and in particular it highlights the patients’ distinctive personal features. As a result of the carried out research the risk factors of ischemic heart disease among able-bodied citizens in the region of Gomel were specified. The article gives the recommendations for the psychological prevention and correction.

On the basis of data of the literature and outcomes of characteristic probings data about intercoupling of a bronchial asthma and a ropiness in nursery age, health risks of evolution of these diseases in antenatal, intranatal and postnatal phases, about agency of character of feeding on first are introduced to year of life on evolution of the yielded pathology.

The article is presented the supervision of the authors of case mixed (atypical) dementia with Alzheimer's disease. The evaluation of patient is carried out with using modern functional, neurointrascopic and psychometric methods of diagnostics. This research detected as Alzheimer’s nature of disease, so and vascular disturbance, that lead to clinical picture of mixed dementia with Alzheimer's disease.