Results of the detection of autoantibodies in patients with chronic HCV-infection are presented. The comparison of importance of autoantibodies both organ specific (to liver specific protein) and organ non-specific (antinuclear and antimitochondrial) is done. The clinical significance of organ specific autoantibodies (to liver specific protein) is high.

The results of intestinal enzymes activity research among 75 complicated duodenal ulcer patients and (perforation, bleeding) and among 75 noncomplicated duodenal ulcer patients are presented. It is marked that complications and operations damage the intestinal digestion. Negative changes resulting to the intestinal dyspepsia correlate with length of the disease and development of complications.

The effectiveness of ozonotherapy in 96 patients with coronary heart disease has been studied both as the monotherapy and within the traditional. It was revealed that ozonotherapy is a highly effective economically beneficial and perspective means of treatment of the patients with the coronary heart disease.

The main goal of this research is evaluation of the influence of hyperbaric oxygenation therapy on the blood cholesterol at the patients with the acute miocardial infarction. In case of inclusion of hyperbaric oxygenation into the standart treatment plan of acute miocardial infarction more rapid normalization of clinical parameters blood cholesterol during 12 month research.

The main goal of this research is evaluation of the influence of hyperbaric oxygenation therapy on the rate of recurrent miocardial infarction and death-rate. In case of inclusion of hyperbaric oxygenation into the standart treatment plan of acute miocardial infarction more rapid normalization of clinical parameters as well as reliable decrease the rate of recurrent miocardial infarction and mortality level has been revealed.

The analysis of quantitative and qualitative structure of microflora of a abdominal cavity of patients with a acute and chronic cholecystitis (n = 40) is executed. It is revealed, that the following macroscopical attributes, revealed at the beginning of the operation, statistically significantly (р < 0,001) testify about plenty of pathogenic microorganisms in a abdominal cavity: the expressed destructive changes of a gall-bladder; presence of fibrin in any departments of a abdominal cavity; hyperemia of parietal peritoneum, extending on some anatomic areas or area simultaneous interventions; a plenty of transparent effusion or its muddy character.

There was studied the function of adrenal glands cortex at 89 patients with pancreas head cancer complicated by obstructive jaundice through cortisol level definition in blood before and after operation. There was performed cholecystojejunoanastomosis with interintestinal fistula from standard laparotomy approaches for control group patients (46 persons). In basic group (43 persons) there was provided choledochoduodenal anastomosis from minilaparotomy approach. It was marked the significant decrease of glucocorticoids level in blood in pre-surgical period. It was revealed that the operations from the minilaparotomy approach performed at such patients provide less negative impact on adrenal glands activity than operations provided from traditional approaches. It decreases the risk of heavy post operative complications.

The article analyses the dependence of serum lipoproteins spectrum on age and sex of residents of the Vitebsk region. The examined serum values are similar on the whole to average European values in corresponding age and sex groups. In older age groups of the both sexes the concentration of lipoproteins atherogenic fractions in blood serum increases but their dynamics possesses sexual features.

The data about quality of the life of the alcohol depended patients in remission time (F10.202) are presented in this articles. The correlation analysis of different parameters of quality of life of the depended persons carried out. It is revealed, that arising on a background of long abstention from the use of alcohol clinical situations (depressions and others) worsen quality of life of the patients with alcoholic dependence: the parameters of subjective satisfaction by life are authentically reduced (p < 0,05), there is not a harmonious structure of a parameter of quality of life. Recommendation directed on improvement of quality of the life of alcohol depended persons during treatment and rehabilitation are formulated on the basis of received data.

The conditions of development of impetuous oxidative stress in red blood cells (oxidative outburst) caused by red blood cell interaction with reagents of system «NaNO₂+H₂O₂» with hemoglobin participation were studied. The avalanche accumulation of reactive species such as ferryhemoglobin, nitrogen dioxide, and peroxynitrite in the reaction of hemoglobin with reagent of the system «NaNO₂+H₂O₂» was revealed at reagent concentration higher than 500 mМ. The intracellular acidosis down to pH 6,5 which accompanies the cellular oxidation stress activates the reactive species production in the hemoglobin reactions. Hypothesis of positive feedback presence in the mechanism of oxidative stress development with hemeprotein participation in cells was advanced.

Problems of higher medical education in modern condition are discussed in our article. We give thoughts about its improvement.

The changes of the sizes and absorb activity of mice alveolar macrophages at 1, 7, 15 and 30 days after separate and combined effects of gamma-irradiation and sulphure oxide were investigated by computer morphometric and immunologic methodes. Irradiation was shown to change the response of alveolar macrophages to the sulphure oxide action.

The paper presents the results of the hygienic assessment of actual nutrition of students of the Belarusian State Medical University. It is determined that the energy value of daily dietary intake is below the physiological line. 24 hours' ration is characterized by low content of proteins, carbohydrates, vitamins and mineral substances. The dietetic anamneses data evidence the disturbance in nutrition regime.

В статье представлены основные медико-технические характеристики медицинского ортопедического тренажера. 

The article reviews material used for production of movable joints endoprostheses. Statistical data on deterioration of endoprosthetic materials in vivo are presented. The paper emphasizes on the deterioration of superhigh-polymeric polyethylene as of the basic polymer friction material in joints endoprostheses. It has been concluded that mechanisms of implants deterioration greatly differ from the mechanisms of functioning of natural joints. Endoprostheses deterioration in vivo happens in more severe conditions than those at stand tests.

Biotechnology methods allow getting homogenous biologically active preparations in virtually unlimited quantities. Recombinant protein purification technology is being constantly improved to increase expression level and minimization of number of protein purification stages. This paper introduces the new method of one-stage recombinant His-Tag fusion adrenodoxin cloning. It keeps all vector advantages for its periplasmatic expression. In this issue, optimized detergents system for effective lysis of bacteria cells has been described.