Clinical case of primary chronic adrenal cortex insufficiency (Addison’s disease)
https://doi.org/10.51523/2708-6011.2025-22-4-17
Abstract
Adrenal insufficiency is a relatively rare but serious disease characterized by decreased production of glucocorticoids and/or mineralocorticoids and adrenal androgens due to adrenal destruction or lack of its stimulation. This condition is characterized with subtle and rather nonspecific signs and symptoms that develop over weeks to months, and often go unnoticed, leading to delays in diagnosis [1]. A high level of clinical suspicion and diagnostic knowledge are required for diagnosis.
The article presents a clinical case of primary chronic adrenal cortex insufficiency in a middle-aged patient. An analysis of literary sources, clinical data, and laboratory test results was performed.
About the Authors
A. V. Pronevich
Gomel State Medical University
Беларусь
Беларусь
Anna V. Pronevich - Senior Lecturer at the Department of Outpatient Therapy and General Medical Practice with the course of Advanced Training and Retraining, Gomel State Medical University.
Gomel
O. L. Nikiforova
Gomel State Medical University
Беларусь
Беларусь
Olga L. Nikiforova - Senior Lecturer at the Department of Outpatient Therapy and General Medical Practice with the course of Advanced Training and Retraining, Gomel State Medical University.
Gomel
References
1. Kumar R, Wassif WS. Adrenal insufficiency. J Clin Pathol. 2022 Jul;75(7):435-442. DOI: https://doi.org/10.1136/jclinpath-2021-207895
2. Lewis A, Thant AA, Aslam A, Aung PPM, Azmi S. Diagnosis and management of adrenal insufficiency. Clin Med (Lond). 2023;23(2):115-118. DOI: https://doi.org/10.7861/clinmed.2023-0067
3. Huecker MR, Bhutta BS, Dominique E. Adrenal Insufficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 17, 2023. [date of access 2025 July 05]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441832/
4. Bathla JS, Chitale A, Shahzad S, Elbathani M, Sarvadevabatla N. Too Dry for Primary Adrenal Insufficiency (PAI): PAI Masked by Volume Depletion. Cureus. 2024;16(5):e61018. DOI: https://doi.org/10.7759/cureus.61018
5. Quénéhervé L, Drui D, Blin J, Péré M, Coron E, Barbara G, Barbaro MR, Cariou B, Neunlist M, Masson D, Bach-Ngohou K. Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms. Sci Rep. 2021 Apr 13;11(1):8077. DOI: https://doi.org/10.1038/s41598-021-87158-2
6. Pelewicz K, Miśkiewicz P. Glucocorticoid Withdrawal-An Overview on When and How to Diagnose Adrenal Insufficiency in Clinical Practice. Diagnostics (Basel). 2021 Apr 20;11(4):728. DOI: https://doi.org/10.3390/diagnostics11040728
7. Quénéhervé L, Drui D, Blin J, Péré M, Coron E, Barbara G, Barbaro MR, Cariou B, Neunlist M, Masson D, Bach-Ngohou K. Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms. Sci Rep. 2021 Apr 13;11(1):8077.
8. Munir S, Quintanilla Rodriguez BS, Waseem M. Addison Disease. In: StatPearls. Treasure Island (FL): StatPearls Publishing; January 30, 2024. [date of access 2025 July 01]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441994/
9. Vance SJ, Horsley JT, Welch MP, Muterspaugh RD, Pandey J. Educational Case: Adrenocortical insufficiency-Causes and pathogenesis. Acad Pathol. 2022 May 17;9(1):100019. DOI: https://doi.org/10.1016/j.acpath.2022.100019
10. Pazderska A, Pearce SH. Adrenal insufficiency - recognition and management. Clin Med (Lond). 2017;17(3):258-262. DOI: https://doi.org/10.7861/clinmedicine.17-3-258
11. Yamamoto T. Latent Adrenal Insufficiency: Concept, Clues to Detection, and Diagnosis. Endocr Pract. 2018;24(8):746-755. DOI: https://doi.org/10.4158/EP-2018-0114
12. Wäscher H, Knauerhase A, Klar B, Postrach T, Weber MA, Willenberg HS. On Primary Adrenal Insufficiency with Normal Concentrations of Cortisol - Early Manifestation of Addison’s Disease. Horm Metab Res. 2024;56(1):16-19. DOI: https://doi.org/10.1055/a-2180-7108
13. Husebye ES, Allolio B, Arlt W, et al. Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency. J Intern Med. 2014;275(2):104-115. DOI: https://doi.org/10.1111/joim.12162
14. Alorni A, Minarelli V, Morelli S. Therapy of adrenal insufficiency: an update. Endocrine. 2013;43(3):514-528. DOI: https://doi.org/10.1007/s12020-012-9835-4
Review
For citations:
Pronevich A.V., Nikiforova O.L. Clinical case of primary chronic adrenal cortex insufficiency (Addison’s disease). Health and Ecology Issues. 2025;22(4):135-140. (In Russ.) https://doi.org/10.51523/2708-6011.2025-22-4-17
Views:
12
JATS XML
Email this article 