The Morphological Assessment of Rats` Liver after the Introduction of the Nucleoside Reverse Transcriptase Inhibitor of Azidothymidine
https://doi.org/10.51523/2708-6011.2019-16-1-12
Abstract
Objective: to study the microscopic and ultrastructural changes in the liver of rats exposed to AZT. Material and methods. The histological and electron microscopic examination of the liver samples with mitochondrial morphometry has been performed. Results . The 7-day administration of AZT does not cause any significant structural changes in the liver. The exposure to the drug for 21 days leads to the development of moderate inflammatory and degenerative processes in the liver, including changes in the structure of hepatocyte mitochondria. Conclusion. One of the pathogenetic mechanisms of the hepatotoxic effect of AZT is its impact on the structural and functional properties of hepatocyte mitochondria.
About the Authors
M. N. Kurbat
Учреждение образования «Гродненский государственный медицинский университет»
Belarus
Belarus
R. I. Kravchuk
Учреждение образования «Гродненский государственный медицинский университет»
Belarus
Belarus
O. B. Ostrovskaya
Учреждение образования «Гродненский государственный медицинский университет»
Belarus
Belarus
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Review
For citations:
Kurbat M.N., Kravchuk R.I., Ostrovskaya O.B. The Morphological Assessment of Rats` Liver after the Introduction of the Nucleoside Reverse Transcriptase Inhibitor of Azidothymidine. Health and Ecology Issues. 2019;(1):61-67. (In Russ.) https://doi.org/10.51523/2708-6011.2019-16-1-12
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