zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2019-16-1-12zdor-98Research ArticleЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА И БИОЛОГИЯEXPERIMENTAL MEDICINE AND BIOLOGYМОРФОЛОГИЧЕСКАЯ ОЦЕНКА ПЕЧЕНИ КРЫС ПРИ ВВЕДЕНИИ НУКЛЕОЗИДНОГО ИНГИБИТОРА ОБРАТНОЙ ТРАНСКРИПТАЗЫ АЗИДОТИМИДИНThe Morphological Assessment of Rats` Liver after the Introduction of the Nucleoside Reverse Transcriptase Inhibitor of AzidothymidineКурбатМ. Н.KurbatM. N.noemail@neicon.ruКравчукР. И.KravchukR. I.noemail@neicon.ruОстровскаяО. Б.OstrovskayaO. B.noemail@neicon.ruУчреждение образования «Гродненский государственный медицинский университет»Belarus201928032019016167Copyright © Курбат М.Н., Кравчук Р.И., Островская О.Б., 20192019Курбат М.Н., Кравчук Р.И., Островская О.Б.Kurbat M.N., Kravchuk R.I., Ostrovskaya O.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/98

Цель: изучить микроскопические и ультраструктурные изменения печени крыс при воздействии AZT. Материалы и методы. Проведено гистологическое и электронно-микроскопическое исследование образцов печени с морфометрией митохондрий. Результаты . 7-суточное введение AZT не вызывает существенных структурных изменений печени. Воздействие препарата на протяжении 21 суток приводит к развитию умеренных воспалительных и дегенеративных процессов в печени, в том числе к изменению структуры митохондрий гепатоцитов. Заключение. Одним из патогенетических механизмов гепатотоксического эффекта AZT является его влияние на структурно-функциональные свойства митохондрий гепатоцитов.

Objective: to study the microscopic and ultrastructural changes in the liver of rats exposed to AZT. Material and methods. The histological and electron microscopic examination of the liver samples with mitochondrial morphometry has been performed. Results . The 7-day administration of AZT does not cause any significant structural changes in the liver. The exposure to the drug for 21 days leads to the development of moderate inflammatory and degenerative processes in the liver, including changes in the structure of hepatocyte mitochondria. Conclusion. One of the pathogenetic mechanisms of the hepatotoxic effect of AZT is its impact on the structural and functional properties of hepatocyte mitochondria.

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The authors declare that there are no conflicts of interest present.