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PRACTICES OF USING TESTOSTERONE REPLACEMENT THERAPY IN MALE PATIENTS WITH ANDROGEN DEFICIENCY AND TYPE 2 DIABETES MELLITUS

https://doi.org/10.51523/2708-6011.2010-7-2-4

Abstract

Androgen deficiency in the aging male has become a topic of increasing interest both healthy men and with various endocrinology diseases, including type 2 diabetes mellitus. The low level of testosterone in obese men is reason of insulin resistance which leads to the type 2 diabetes mellitus. Many reports have shown that testosterone replacement therapy leads to improvement of parameters of a metabolic syndrome. Investigation and treatment androgen deficiency allow not only prevent diabetes type 2, but also have a good control of diabetes. In our work we have shown that testosterone gel is an effective preparation for androgen replacement therapy in patients with type 2 diabetes mellitus, allowing not only to restore normal level of testosterone but also to control of weight, lipids, insulin resistance and bone mineral density.

About the Authors

O. N. Vasilkova
Gomel State Medical University
Belarus


T. V. Mokhort
Belorussian State Medical University, Minsk
Belarus


References

1. Morley, J. The elderly Type 2 diabetic patient: special considerations / J. Morley // Diabet. Metab. - 1998. - № 15 (4). - Р. 41-46.

2. Association between plasma total testosterone and cardiovascularrisk factor healthy adult men: The telecom Study/ D. Simon [et al.] // J. Clin. Endocrinol. Metab. - 1997. -№ 82 (2). - Р. 682-685.

3. Sexual function in men with diabetes type 2: association with glycemic control / J. Romeo [et al.] // J. Urol. - 2000. - № 163 (3). - Р. 788-791.

4. The pituitary-gonadal axis and health in elderly men: a study of men born in 1913 / G. Tibblin [et al.] // Diabetes. - 1996. - № 45 (11). - Р. 1605-1609.

5. Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: The Telecom Study / D. Simon [et al.] // J Clin Endocrinol Metab. - 1997. - № 82(2). - Р. 682-685.

6. Chen, R. Y. Relative androgen deficiency in relation to obesity and metabolic status in older men / R. Y. Chen, G. A. Wittert, G. R. Andrews // Diabetes Obes Metab. - 2006. - № 8(4). - Р. 429-435.

7. Effects of androgen therapy on adipose tissue and metabolism in older men / E. T. Schroeder [et al.] // J Clin Endocrinol Metab. - 2004. - № 89(10). - Р. 4863-4872.

8. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes / D. Kapoor [et al.] // Eur J Endocrinol. - 2006. - № 154(6). - Р. 899-906.

9. Do reproductive hormones modify insulin sensitivity and metabolism in older men? A randomized, placebo-controlled clinical trial of recombinant human chorionic gonadotropin / P. Y. Liu [et al.] // Eur J Endocrinol. - 2003. - № 148(1). - Р. 55-66.

10. Oral Testosterone Supplementation Increases Muscle and Decreases Fat Mass in Healthy Elderly Males With Low-Normal Gonadal Status / G. A. Wittert [et al.] // J Gerontol Series Biol Sci Med Sci - 2003. - № 58. - Р. 618-625.


Review

For citations:


Vasilkova O.N., Mokhort T.V. PRACTICES OF USING TESTOSTERONE REPLACEMENT THERAPY IN MALE PATIENTS WITH ANDROGEN DEFICIENCY AND TYPE 2 DIABETES MELLITUS. Health and Ecology Issues. 2010;(2):19-23. (In Russ.) https://doi.org/10.51523/2708-6011.2010-7-2-4

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ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)