THE DYNAMICS OF PROINFLAMMATORY CYTOKINES IN DIFFERENT VARIANTS OF ANTIBACTERIAL THERAPY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATIONS
https://doi.org/10.51523/2708-6011.2009-6-3-6
Abstract
The dynamics (before and after treatment) of proinflammatory cytokines (interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α)) levels in serum and in bronchoalveolar fluid (BALF), of indices of BALF cytograms, of indices of respiratory function (RF), of bronchoscopic data in different variants of antinflammatory therapy of chronic obstructive pulmonary disease exacerbations (COPD) was studied in 60 patients. Statistically significant decline in percentages of neutrophils and in IL-8 and TNF-α - levels in serum and in BALF was revealed. It was considered, that the Indices of BALF cytograms and cytokine levels in BALF can be used in treatment efficacy monitoring. Clarithromycin is more effective in the reduction of activity of inflammatory process in COPD exacerbations.
Keywords
About the Authors
E. A. Karazei
Belarusian Medical Academy of Post-Graduate Education
Belarus
Belarus
E. I. Davidovskaya
Belarusian Medical Academy of Post-Graduate Education
Belarus
Belarus
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Review
For citations:
Karazei E.A., Davidovskaya E.I. THE DYNAMICS OF PROINFLAMMATORY CYTOKINES IN DIFFERENT VARIANTS OF ANTIBACTERIAL THERAPY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATIONS. Health and Ecology Issues. 2009;(3):30-35. (In Russ.) https://doi.org/10.51523/2708-6011.2009-6-3-6
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