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THE LETHAL OUTCOME PROBABILITY FORECASTING AT HIV-INFECTED PATIENTS IN VIEW OF ANTIRETROVIRAL THERAPY

https://doi.org/10.51523/2708-6011.2009-6-2-20

Abstract

The probability of a lethal outcome within 12 months in 331 HIV-infected of the patients accepting antiretroviral therapy (ART) is defined. With the help of regression model were chosen five parameters which influence on risk of a lethal outcome is proved: sex, disease stage, CD4 cells level, haemoglobin level, presence of the diagnosed tuberculosis. According to the developed model probabilities of death in 3, 6, 9 and 12 months from the beginning of ART have been defined.

About the Authors

E. I. Kozorez
Gomel State Medical University
Belarus


S. V. Zhavoronok
Byelorussian Medical Academy of Postgraduate Education
Belarus


V. M. Mitsura
Gomel State Medical University
Belarus


E. L. Krasavtsev
Gomel State Medical University
Belarus


References

1. ВИЧ-инфекция клиника, диагностика, лечение / В. В. Покровский [и др.]; под общ. ред. В. В. Покровского. - М.: ГЭОТАР-МЕД, 2003. - 488 с.

2. Еремин, В. Ф. Антиретровирусная терапия: прошлое, настоящее, успехи и проблемы / В. Ф. Еремин, И. А. Карпов // Рецепт. - 2001. - № 4 (18). - С. 66-80.

3. Bartlett, J. Medical Management of HIV infection 2005-2006 / J. Bartlett, J. Gallant. - Johns Hopkins University School of Medicine, 2006. - 455 p.

4. Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies / M. Egger [et al.] // Lancet. - 2002. - Vol. 360. - P. 119-129.

5. Prognostic importance of initial response in HIV-1infected patients starting potent antiretroviral therapy: analysis of prospective studies / G. Chene [et al.] // Lancet. - 2003. - Vol. 362. - P. 679-686.

6. Plasma viral load and CD4-lymphocytes as prognostic markers of HIV-1infection / J. W. Mellors [et al.] // Annals of Internal Medicine. - 1997. - Vol. 126. - P. 946-954.

7. Risk factors for high mortality in patients on antiretroviral treatment in a rural district of Malawi / R. Zachariah [et al.] // AIDS. - 2006. - Vol. 20, № 18. - P. 2350-2360.

8. Prognosis of HIV-1-infected patients up to 5 years after initiation of HAART: collaborative analysis of prospective studies / The Antiretroviral Therapy (ART) Cohort Collaboration // AIDS. - 2007. - Vol. 21, № 8. - P. 1185-1197.

9. Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy / S. Grabar [et al.] // Annals of Internal Medicine. - 2000. - Vol. 133. - P. 401-410.

10. Outcome and predictors of failure of highly active antiretroviral therapy: one-year follow-up of a cohort of human immunodeficiency virus type 1-infected persons / F. W. Wit [et al.] // Journal of Infectious Diseases. - 1999. - Vol. 179. - P. 796-798.

11. HIV treatment response and prognosis in Europe and North America in the first decade of highly active antiretroviral therapy: a collaborative analysis / M. T. May [et al] // Lancet. - 2006. - Vol. 368. - P. 451-458.

12. Agonist-like, replacement pharmacotherapy for stimulant abuse and dependence / J. Grabowski [et al.] // Addictive Behaviors. - 2004. - Vol. 29. - P. 1439-1464.

13. Mortality and causes of death in adults receiving highly active antiretroviral therapy in Senegal: a 7-year cohort study / J. F. Etard // AIDS. - 2006. - Vol. 20, № 8. - P. 1181-1189.

14. Virological response to a triple nucleoside/nucleotide analogue regimen over 48 weeks in HIV-1 infected adults in Africa / DART Virology group and Trial Team // AIDS. - 2006. - Vol. 20. - P. 1391-1399.


Review

For citations:


Kozorez E.I., Zhavoronok S.V., Mitsura V.M., Krasavtsev E.L. THE LETHAL OUTCOME PROBABILITY FORECASTING AT HIV-INFECTED PATIENTS IN VIEW OF ANTIRETROVIRAL THERAPY. Health and Ecology Issues. 2009;(2):100-105. (In Russ.) https://doi.org/10.51523/2708-6011.2009-6-2-20

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ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)