MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL DESCRIPTION OF INTERSTITIAL TISSUE IN PRIMARY GLOMERULOPATHY
https://doi.org/10.51523/2708-6011.2009-6-2-5
Abstract
The purpose of our study was to ascertain the possible relationships between number of interstitial myofibroblasts, TGF-b and interstitial deposition of matrix proteins in the renal tissue of patients with primary glomerulopathies with the use of immunostaining. There was a significant correlation between level of proteinuria and interstitial a-SMA expression, and tubular expression of TGF-b. Interstitial a-SMA expression was significantly higher in patients with nephrotic proteinuria level compared with patients with urinary protein excretion less then 1 g/1. A highly significant correlation was also evident between the number of interstitial myofibroblasts and interstitial deposition of collagen types IV and fibronectin (p < 0,05). We found that tubulointerstitial changes in the renal tissue of patients with proteinuric glomerulopathies were accompanied by increases number of interstitial myofibroflasts and expression of collagen type IV and fibronectin.
About the Authors
V. V. Savosh
Belurussian State Medical University
Belarus
Belarus
T. A. Liatkouskaya
Belurussian State Medical University
Belarus
Belarus
E. D. Cherstvoy
Belurussian State Medical University
Belarus
Belarus
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Review
For citations:
Savosh V.V., Liatkouskaya T.A., Cherstvoy E.D. MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL DESCRIPTION OF INTERSTITIAL TISSUE IN PRIMARY GLOMERULOPATHY. Health and Ecology Issues. 2009;(2):26-30. (In Russ.) https://doi.org/10.51523/2708-6011.2009-6-2-5
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