RECURRENCE OF LOCALLY SPREAD GASTRIC CANCER after radical treatment: the adjuvant chemioradiation therapy role

Abstract

The immediately and long-term results of treatment and structure of relapse are studied at 149 patients with gastric cancer (GC) of the IV stage (T4N1-3M0-1), being on treatment in the Gomel regional clinical oncologic centre in a period from 1996 to 2005. A basic group (I) 64 patients which after operation was conduct the postoperative course of radial therapy (RT) in a total dose 50-60 Gr and 4-6 courses of postoperative polichemiotherapy. A control group (II) patients which only surgical treatment was conducted to. All patient is execute the combined operations with lymphadenoectomy in a volume no less D2.The analysis of immediately results of treatment of patients of I group showed, the use of postoperative chemioradiation therapy does not lead to development of heavy complications and provides the satisfactory long-term results of treatment of patients of GC IV stage: five-year survivability in a I group 20,7+5,7% comparing to II group - 9,5+3,4%. Specific gravity of patients with a local relapse, 3,0% in a basic group, and in a control group 29,0%. Cases of appearance the isolated local relapses at the patients of the I group were not observed, while the patients of the II group were exposed in 22,3% cases, that testifies to the high degree of local control of tumour process at patients, gettings postoperative chemioradiation therapy.