MITOCHONDRIAL DNA AS AN OBJECT FOR BIODOSIMETRY AND BIOINDICATION OF ADDITIONAL IRRADIATION
https://doi.org/10.51523/2708-6011.2004-1-1-2
Abstract
If was shown that mtDNA «common deletion» can be used as a marker of irradiation for biological dosimetry.
About the Authors
S.B MELNOV
Полесский государственный университет
Belarus
Belarus
W.F. BLAKELY
Russian Federation
S ZULLO
References
1. Cai J., Yang J., Jones D.P. Mitochondrial control apoptosis: the role of cytochrome С. // Biochemical andbiophysical research communications. — 1998. — № 1366139—149.
2. Caron F., Jaco C., Rouviere-Yaniv J. Charaof a histone-like protein extracted from yeast mitochondria. // PNatl. Acad .Sci. USA. — 1979. — V. 76. — P. 426
3. Clayton D.A. Replication of animal mitochondrDNA. // Cell. — 1982. — V. 28. — P. 693—705.
4. Clayton D.A. Nuclear gadgets in mitochreplication and transcription. // Trends Biochem.Sci. —1991. — V. 16. — P. 107—111.
5. DiMauro S., Bonilla E., Davidson M., Harino M., ShonE.A. Mitochondria in neuromuscular disorders. // Biochimica et Biophysica Acta. — 1998. — P. 199—210.
6. Gattermann N., Berneburg M., Heinisch J., Aul C., Schneider W. Detection of the ageing-associated 5-kb common deletion of mitochondriaDDNA in blood and bone marrow of hematologicallynormal adults. Absence of the deletion in clonal bone mardisorders. // Leukemia. — 1995. — V. 9. — P. 1704—1710.
7. Gosden J.R., Lawrie S.S., Cook H.J. A clonDNA sequence in human chromosome heteromorphisms. // Cytogenet. Cell Genet. — 1981. — V. 29. — P. 32
8. Kubota N., Hayashi J. I., Inada T. Iwamura Y. Induction of a particular deletion in mitochondrial DNA by Xrays depends on the inherent radiosensitivity of the cells. // Rad. Res. — 1997. — V. 148, №1. — P. 395—398.
9. Larsson N. G., Clayton D.A. Molecular genetic aspectshuman mitochondrial disordes. // Annu. Rev. Genet. — 1995. — V.151. — P.78.
10. Liu V.W.S., Zhang С. Nagley P. Mutations in mitochondrial DNA accumulate differentially in three different hutissues during ageing. // Nucleic Acids Research. — 1998. — V№5. — 1268—1275.
11. Reynier P., Malthiery Y. Accumulation of deletions mtDNA during tissue aging: analysis by long PCR. // Biochemical and biophysical research communications. — 1995. — V. 217, №1. — P. 59—67.
12. Shadel G.S., Clayton D.A. Mitochondrial DNA maintenance in vertebrates. // Annu. Ray. Biochem. — 1997. —66. — P. 409—435.
Review
For citations:
MELNOV S., BLAKELY W., ZULLO S. MITOCHONDRIAL DNA AS AN OBJECT FOR BIODOSIMETRY AND BIOINDICATION OF ADDITIONAL IRRADIATION. Health and Ecology Issues. 2004;(1):11-15. (In Russ.) https://doi.org/10.51523/2708-6011.2004-1-1-2
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