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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2004-1-1-2</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-2223</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕДИЦИНСКИЕ АСПЕКТЫ ЧЕРНОБЫЛЬСКОЙ КАТАСТРОФЫ</subject></subj-group></article-categories><title-group><article-title>МИТОХОНДРИАЛЬНАЯ ДНК КАК ОБЪЕКТ ДЛЯ БИОДОЗИМЕТРИИ И БИОИНДИКАЦИИ ПРИ ДОПОЛНИТЕЛЬНЫХ РАДИАЦИОННЫХ</article-title><trans-title-group xml:lang="en"><trans-title>MITOCHONDRIAL DNA AS AN OBJECT FOR BIODOSIMETRY AND BIOINDICATION OF ADDITIONAL IRRADIATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельнов</surname><given-names>Сергей Борисович</given-names></name><name name-style="western" xml:lang="en"><surname>MELNOV</surname><given-names>S.B</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блекли</surname><given-names>В.Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>BLAKELY</surname><given-names>W.F.</given-names></name></name-alternatives></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зуло</surname><given-names>С</given-names></name><name name-style="western" xml:lang="en"><surname>ZULLO</surname><given-names>S</given-names></name></name-alternatives></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Полесский государственный университет</institution></aff><aff xml:lang="en"><institution>Полесский государственный университет</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2004</year></pub-date><pub-date pub-type="epub"><day>20</day><month>05</month><year>2004</year></pub-date><volume>0</volume><issue>1</issue><issue-title>Проблемы здоровья и экологии</issue-title><fpage>11</fpage><lpage>15</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мельнов С.Б., Блекли В., Зуло С., 2004</copyright-statement><copyright-year>2004</copyright-year><copyright-holder xml:lang="ru">Мельнов С.Б., Блекли В., Зуло С.</copyright-holder><copyright-holder xml:lang="en">MELNOV S., BLAKELY W., ZULLO S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/2223">https://journal.gsmu.by/jour/article/view/2223</self-uri><abstract><p>Показано, что «обычная делеция» мтДНК может быть использована как маркер облучения для биологической дозиметрии.</p></abstract><trans-abstract xml:lang="en"><p>If was shown that mtDNA «common deletion» can be used as a marker of irradiation for biological dosimetry.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>БИОДОЗИМЕТРИЯ</kwd><kwd>МИТОХОНДРИЯ</kwd><kwd>МТДНК</kwd></kwd-group><kwd-group xml:lang="en"><kwd>BIODOSIMETRY</kwd><kwd>MITOCHONDRIA</kwd><kwd>MTDNA</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cai J., Yang J., Jones D.P. Mitochondrial control of</mixed-citation><mixed-citation xml:lang="en">Cai J., Yang J., Jones D.P. Mitochondrial control apoptosis: the role of cytochrome С. // Biochemical andbiophysical research communications. — 1998. — № 1366139—149.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">apoptosis: the role of cytochrome С. // Biochemical and</mixed-citation><mixed-citation xml:lang="en">Caron F., Jaco C., Rouviere-Yaniv J. Charaof a histone-like protein extracted from yeast mitochondria. // PNatl. Acad .Sci. USA. — 1979. — V. 76. — P. 426</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">biophysical research communications. — 1998. — No 1366.-P.</mixed-citation><mixed-citation xml:lang="en">Clayton D.A. Replication of animal mitochondrDNA. // Cell. — 1982. — V. 28. — P. 693—705.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">—149.</mixed-citation><mixed-citation xml:lang="en">Clayton D.A. Nuclear gadgets in mitochreplication and transcription. // Trends Biochem.Sci. —1991. — V. 16. — P. 107—111.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Caron F., Jaco C., Rouviere-Yaniv J. Characterisation</mixed-citation><mixed-citation xml:lang="en">DiMauro S., Bonilla E., Davidson M., Harino M., ShonE.A. Mitochondria in neuromuscular disorders. // Biochimica et Biophysica Acta. — 1998. — P. 199—210.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">of a histone-like protein extracted from yeast mitochondria. // Proc.</mixed-citation><mixed-citation xml:lang="en">Gattermann N., Berneburg M., Heinisch J., Aul C., Schneider W. Detection of the ageing-associated 5-kb common deletion of mitochondriaDDNA in blood and bone marrow of hematologicallynormal adults. Absence of the deletion in clonal bone mardisorders. // Leukemia. — 1995. — V. 9. — P. 1704—1710.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Natl. Acad .Sci. USA. — 1979. — V. 76. — P. 4265-4269.</mixed-citation><mixed-citation xml:lang="en">Gosden J.R., Lawrie S.S., Cook H.J. A clonDNA sequence in human chromosome heteromorphisms. // Cytogenet. Cell Genet. — 1981. — V. 29. — P. 32</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Clayton D.A. Replication of animal mitochondrial</mixed-citation><mixed-citation xml:lang="en">Kubota N., Hayashi J. I., Inada T. Iwamura Y. Induction of a particular deletion in mitochondrial DNA by Xrays depends on the inherent radiosensitivity of the cells. // Rad. Res. — 1997. — V. 148, №1. — P. 395—398.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">DNA. // Cell. — 1982. — V. 28. — P. 693—705.</mixed-citation><mixed-citation xml:lang="en">Larsson N. G., Clayton D.A. Molecular genetic aspectshuman mitochondrial disordes. // Annu. Rev. Genet. — 1995. — V.151. — P.78.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Clayton D.A. Nuclear gadgets in mitochondrial DNA</mixed-citation><mixed-citation xml:lang="en">Liu V.W.S., Zhang С. Nagley P. Mutations in mitochondrial DNA accumulate differentially in three different hutissues during ageing. // Nucleic Acids Research. — 1998. — V№5. — 1268—1275.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">replication and transcription. // Trends Biochem.Sci. —</mixed-citation><mixed-citation xml:lang="en">Reynier P., Malthiery Y. Accumulation of deletions mtDNA during tissue aging: analysis by long PCR. // Biochemical and biophysical research communications. — 1995. — V. 217, №1. — P. 59—67.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">— V. 16. — P. 107—111.</mixed-citation><mixed-citation xml:lang="en">Shadel G.S., Clayton D.A. Mitochondrial DNA maintenance in vertebrates. // Annu. Ray. Biochem. — 1997. —66. — P. 409—435.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">DiMauro S., Bonilla E., Davidson M., Harino M., Shon</mixed-citation><mixed-citation xml:lang="en">DiMauro S., Bonilla E., Davidson M., Harino M., Shon</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">E.A. Mitochondria in neuromuscular disorders. // Biochimica et</mixed-citation><mixed-citation xml:lang="en">E.A. Mitochondria in neuromuscular disorders. // Biochimica et</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Biophysica Acta. — 1998. — P. 199—210.</mixed-citation><mixed-citation xml:lang="en">Biophysica Acta. — 1998. — P. 199—210.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gattermann N., Berneburg M., Heinisch J.,</mixed-citation><mixed-citation xml:lang="en">Gattermann N., Berneburg M., Heinisch J.,</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Aul C., Schneider W. Detection of the ageing-</mixed-citation><mixed-citation xml:lang="en">Aul C., Schneider W. Detection of the ageing-</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">associated 5-kb common deletion of mitochondrial</mixed-citation><mixed-citation xml:lang="en">associated 5-kb common deletion of mitochondrial</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">DDNA in blood and bone marrow of hematologically</mixed-citation><mixed-citation xml:lang="en">DDNA in blood and bone marrow of hematologically</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">normal adults. Absence of the deletion in clonal bone marrow</mixed-citation><mixed-citation xml:lang="en">normal adults. Absence of the deletion in clonal bone marrow</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">disorders. // Leukemia. — 1995. — V. 9. — P. 1704—1710.</mixed-citation><mixed-citation xml:lang="en">disorders. // Leukemia. — 1995. — V. 9. — P. 1704—1710.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Gosden J.R., Lawrie S.S., Cook H.J. A cloned</mixed-citation><mixed-citation xml:lang="en">Gosden J.R., Lawrie S.S., Cook H.J. A cloned</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">DNA sequence in human chromosome heteromorphisms. //</mixed-citation><mixed-citation xml:lang="en">DNA sequence in human chromosome heteromorphisms. //</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Cytogenet. Cell Genet. — 1981. — V. 29. — P. 32-39.</mixed-citation><mixed-citation xml:lang="en">Cytogenet. Cell Genet. — 1981. — V. 29. — P. 32-39.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kubota N., Hayashi J. I., Inada T. Iwamura Y.</mixed-citation><mixed-citation xml:lang="en">Kubota N., Hayashi J. I., Inada T. Iwamura Y.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Induction of a particular deletion in mitochondrial DNA by Xrays</mixed-citation><mixed-citation xml:lang="en">Induction of a particular deletion in mitochondrial DNA by Xrays</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">depends on the inherent radiosensitivity of the cells. // Rad. Res. —</mixed-citation><mixed-citation xml:lang="en">depends on the inherent radiosensitivity of the cells. // Rad. Res. —</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">— V. 148, No1. — P. 395—398.</mixed-citation><mixed-citation xml:lang="en">— V. 148, No1. — P. 395—398.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Larsson N. G., Clayton D.A. Molecular genetic aspects</mixed-citation><mixed-citation xml:lang="en">Larsson N. G., Clayton D.A. Molecular genetic aspects</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">human mitochondrial disordes. // Annu. Rev. Genet. — 1995. — V.29:</mixed-citation><mixed-citation xml:lang="en">human mitochondrial disordes. // Annu. Rev. Genet. — 1995. — V.29:</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">— P.78</mixed-citation><mixed-citation xml:lang="en">— P.78</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Liu V.W.S., Zhang С. Nagley P. Mutations in</mixed-citation><mixed-citation xml:lang="en">Liu V.W.S., Zhang С. Nagley P. Mutations in</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">mitochondrial DNA accumulate differentially in three different human</mixed-citation><mixed-citation xml:lang="en">mitochondrial DNA accumulate differentially in three different human</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">tissues during ageing. // Nucleic Acids Research. — 1998. — V.26,</mixed-citation><mixed-citation xml:lang="en">tissues during ageing. // Nucleic Acids Research. — 1998. — V.26,</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">No5. — 1268—1275.</mixed-citation><mixed-citation xml:lang="en">No5. — 1268—1275.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Melnov S., Zullo S.J., Hamel C.J.C., PrasannaP.G.S.</mixed-citation><mixed-citation xml:lang="en">Melnov S., Zullo S.J., Hamel C.J.C., PrasannaP.G.S.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Pogozelski W.K., Fischel-Ghodsian N., Merril C.R., Blakely W.F.</mixed-citation><mixed-citation xml:lang="en">Pogozelski W.K., Fischel-Ghodsian N., Merril C.R., Blakely W.F.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Cytological detection of the 4977-bp «common» mitochondrial</mixed-citation><mixed-citation xml:lang="en">Cytological detection of the 4977-bp «common» mitochondrial</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">DNA deletion using an in situ PCR assay // Mitohondria: interaction of two</mixed-citation><mixed-citation xml:lang="en">DNA deletion using an in situ PCR assay // Mitohondria: interaction of two</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">genomes. Mitohondria interest group minisymposium mitohondria. —</mixed-citation><mixed-citation xml:lang="en">genomes. Mitohondria interest group minisymposium mitohondria. —</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">— Р. 25—26.</mixed-citation><mixed-citation xml:lang="en">— Р. 25—26.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Reynier P., Malthiery Y. Accumulation of deletions in</mixed-citation><mixed-citation xml:lang="en">Reynier P., Malthiery Y. Accumulation of deletions in</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">mtDNA during tissue aging: analysis by long PCR. // Biochemical</mixed-citation><mixed-citation xml:lang="en">mtDNA during tissue aging: analysis by long PCR. // Biochemical</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">and biophysical research communications. — 1995. — V. 217, No1.</mixed-citation><mixed-citation xml:lang="en">and biophysical research communications. — 1995. — V. 217, No1.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">— P. 59—67.</mixed-citation><mixed-citation xml:lang="en">— P. 59—67.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Shadel G.S., Clayton D.A. Mitochondrial DNA</mixed-citation><mixed-citation xml:lang="en">Shadel G.S., Clayton D.A. Mitochondrial DNA</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">maintenance in vertebrates. // Annu. Ray. Biochem. — 1997. —V.</mixed-citation><mixed-citation xml:lang="en">maintenance in vertebrates. // Annu. Ray. Biochem. — 1997. —V.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">— P. 409—435.</mixed-citation><mixed-citation xml:lang="en">— P. 409—435.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
