Importance of GPER1, HO-1, HO-2 expression in the endometrium in patients with chronic endometritis
https://doi.org/10.51523/2708-6011.2021-18-3-21
Abstract
Objective. To evaluate the expression of G protein-coupled estrogen receptor (GPER1), heme oxygenase-1 (HO-1), and heme oxygenase-2 (HO-2) in patients with chronic endometritis and to determine the importance of these markers in the diagnosis of the disease.
Materials and methods. The results of GPER1, HO-1, and HO-2 expression were analyzed in patients with a confrmed diagnosis of chronic endometritis and in patients of the comparison group.
Results. The expression of GPER1 ≤ 79 % (sensitivity — 100.00 %; specifcity — 95.83 %; +PV — 94.00 %; -PV — 100 %), the expression of HO-1 positive cells > 5 % (sensitivity — 100.00 %; specifcity -100%; +PV — 100 %; -PV — 100 %) are signifcant for the development of chronic endometritis. The endometrial glands in the patients with chronic endometritis express the markers of inflammation HO-1 and HO-2 signifcantly more often than in the comparison group (p < 0.001).
Conclusion. The presented data indicate defects of the enzymes of iron metabolism and non-canonical pathways of estrogen reception in chronic endometritis. The determination of GPER1, HO-1, HO-2 expression in the endometrium in patients with chronic endometritis is a reliable criterion and may be used in the diagnosis of the disease.
Supporting agencies: The research work was funded by the innovation fund of the Gomel Regional Executive Committee within the framework of the project “To develop and implement a method of personalized treatment of hyperplastic processes of the endometrium of women”, State Registration No.20201765 dated 05.11.2020.
About the Authors
Yu. A. Lyzikova
Gomel State Medical University
Belarus
Belarus
Yuliya A. Lyzikova, PhD (Med), Associate Professor, Associate Professor at the Department of Obstetrics and Gynecology with the course of the Faculty of Professional Development and Retraining
Gomel
D. A. Zinovkin
Gomel State Medical University
Belarus
Belarus
Dmitry А. Zinovkin, Assistant Lecturer at the Department of Pathologic Anatomy
Gomel
E. V. Voropaev
Gomel State Medical University
Belarus
Belarus
Evgenii V. Voropaev, PhD (Med), Associate Professor, Vice-rector in charge of scientifc work
Gomel
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Review
For citations:
Lyzikova Yu.A., Zinovkin D.A., Voropaev E.V. Importance of GPER1, HO-1, HO-2 expression in the endometrium in patients with chronic endometritis. Health and Ecology Issues. 2021;18(3):168-174. (In Russ.) https://doi.org/10.51523/2708-6011.2021-18-3-21
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