Objective. To analyze data on the role of psychosomatic symptoms in development of disorders of organs and organ systems.

Materials and methods. The analysis of publications in PubMed, Web of Science, Elibrary, Elsevier and CyberLeninka systems from 2020 to 2025 describing the role of psychosomatic disorders in various fields of medicine, course features of such conditions, specifics of the therapeutic and diagnostic process was conducted. Search terms “psychosomatic disorder”, “functional diseases”, “psychosomatic medicine” were used. A total of 20 original articles were selected.

Results. The current concepts of development reasons and pathogenetic mechanisms of psychosomatic disorders, modern classifications of psychosomatic disorders, and approaches to the treatment of psychosomatic symptoms have been studied.

Conclusion. Psychosomatic disorders, especially associated with existing pathological processes, not only aggravate the course of existing diseases, but also increase the risk of developing new ones, creating a complex heteromorphic background for a clinician. Diagnosis, treatment, and prevention of these disorders often requires a multidisciplinary approach to a patient management involving specialists of various fields of medicine, including those with knowledge of basic rules of mental functioning and skills to assess the individual social and cultural aspects of each patient as an individual.

The review reflects modern ideas of the variants of the course of kidney diseases in patients infected with human immunodeficiency virus (HIV): from HIV-associated nephropathy to chronic kidney disease (CKD). Such risk factors for the development of kidney diseases in HIV-infected patients as the level of immunosuppression, viral load, antiretroviral therapy, concomitant diseases were analyzed. Special attention has been given to the mechanisms of the pathogenesis of HIV-associated nephropathy and approaches to its diagnosis.

Taking into account the variety of morphological and clinical kidney lesions, we presented modern approaches to their early diagnosis.

Objective. To study interrelation of personality anxiety (PA) with adaptation in students of medical university.

Materials and methods. A comparative study of PA and adaptation interrelation of 123 students of 1st, 4th and 6th years of education in Gomel State Medical University aged from 17 to 28 (20.48±2.3 years old) years old was carried out by means of clinical, experimental and psychological, and integrative test of anxiety in particular, as well as by statistical methods.

Results. It was established that the average value of integrative PA of medical university students, being close to a high level of expression in the junior years (5.93±1.96), gradually with the years of study, statistically significantly decreased in senior years of study (4.97±1.75, p<0.05). The greatest contribution to the formation of integrative anxiety in students was associated with the auxiliary components such as “assessment of prospects” and “asthenic component”, and to a lesser extent with the components such as “emotional discomfort”, “phobic component” and “social protection”.

Conclusion. High and even moderate PA of students contributed to better academic performance (p<0.0001) and successful adaptation of students (p<0.01), but high anxiety increased the risk of maladaptation in hardship (p<0.05). Monitoring of PA level using the integrative test of anxiety can help differentiated psychological correction in crisis maladaptation, and the pedagogical process of forming a mature personality of students mastering “helping” professions.

Objective. To study the prognostic power of individual clinical and diagnostic features and serum iron levels in patients with severe traumatic brain injury (TBI) in terms of possible brain death.

Materials and methods. A total of 107 patients with severe TBI who underwent intensive care in the anaesthesiology and resuscitation departments of Mogilev region were included in the prospective non-randomized study. Two groups of patients were formed: group 1 (n=56) – patients with a positive treatment outcome, group 2 (n=51) – patients who were diagnosed with brain death.

Results. The level of consciousness according to the Glasgow Coma Scale (GCS) upon admission in group 1 was 12 (8; 14) points, in group 2 – 5 (4; 6) points, p<0.0001. GCS was a good predictor of the onset of brain death (AUC 0.895, p<0.0001). The severity of organ dysfunction assessment (SOFA) score in group 1 was 3 (1; 6) points, in group 2 – 7.5 (6; 11) points, p<0.0001 (AUC 0.821, p<0.0001). The volume of intracranial hematoma on CT upon admission was 76 (56; 107) ml in group 1, 150 (75; 185) ml in group 2, p=0.006 (AUC 0.706, p=0.01). The displacement of the midline structures of the brain in group 1 was 5 (3; 9) mm, in group 2 – 13.5 (4; 17) mm, p=0.025 (AUC 0.690, p=0.042). The level of serum iron (from day 1 to day 10) in group 1 was 6.4 (3.3; 11.5) μmol/l, in group 2 – 3.2 (2; 4.9) μmol/l, p<0.0001 (AUC 0.721, p<0.0001).

Conclusion. A comprehensive analysis of quantitative indicators of head CT data, number of points according to the GCS and SOFA scale, as well as the level of serum iron allows us to predict the onset of brain death in patients with severe TBI.

Objective. To analyze clinical laboratory and X-ray characteristics of radiation-induced osteonecrosis of jaws in patients with malignant tumors of the maxillofacial area.

Materials and methods. The study of medical histories of 26 cancer patients with osteonecrosis of jaws underwent hospital treatment between 2019 and 2024 was carried out. CBCT tomography and microbiological studies were used as additional diagnostic methods used for patients with osteonecrosis of jaws. Sensitivity to antibacterial drugs was conducted by disc diffusion method. One of clinical cases was described.

Results. Most patients with radiation-induced osteonecrosis were male (95.5%, n=21, p<0.05). 85.7% (n=18) of them reported long-term smoking. Conducting CBCT allows to accurately establish localization of the pathological process, to determine extent of prevalence, and presence of associated complications. In the course of a microbiological study, it was found that microorganisms from patients with osteonecrosis had resistance to a number of antibacterial drugs used for empirical therapy.

Conclusion. The presence of harmful habits, such as smoking, in patients with malignant tumors of the maxillofacial area, increases the likelihood of developing radiation-induced osteonecrosis. The use of additional study methods in clinical practice such as CBCT, microbial profile analysis and determination of sensitivity of the microorganisms present in patients to antibacterial drugs are necessary steps for treatment of patients with osteonecrosis. Chronic course, developing complications and poor quality of life necessitate the need to find new methods and means for etiopathogenic treatment of patients with radio-induced osteonecrosis of jaws.

Objective. To establish the effect of mode of delivery, aspects of obstetric history (parity, miscarriages), and gestational weight gain on cytokines and immunoglobulins content in cord blood (CB) and breast milk (BM).

Materials and methods. 379 pregnant women were included in the study. Study materials: CB; BM expressed in 1 (BM1) and 3 months (BM2) after childbirth. L-4, IL-5, IL-6, IL-10, IL-25, TSLP, IFN-γ, TGFβ1, TGFβ2, CCL17, CCL22, CXCL10 were typed in body fluids by the method of enzyme immunoassay (ELISA).

Results. Caesarean deliveries are associated with essential higher concentrations of CCL17 in CB (p=0.0006), IgE in BM1 (p=0.02), IL-5 in BM2 (p=0.048) and lower sIgA level in BM2 (p=0.05), more significant decrease in TGFβ1 concentration in BM within first three months (p=0.004). Significantly higher levels of ССL17 (p=0,04) and IgE (p=0,019) in CB, IL-5 (p=0,037) and IFN-γ (p=0,031) in BM2 were in a group of women having miscarriages in their medical history. Primiparous women had higher levels of CCL22 (p=0.0006) and IL-4 (p=0.032) in CB, as well as IL-4 (p=0.047) and IL-5 (p=0.047) in BM1, and IL-6 in BM2 (p=0.035).

Conclusion. Women delivered by caesarean section, primiparous women, and women with miscarriages in obstetric history were associated with higher BM and CB IgE levels and T2-associated cytokine concentration (IL-4, IL-5, CCL17, CCL22), as well IL-6 and IFN-γ, but lower sIgA and TGFβ1 concentrations. Effect of such cytokine patterns during the period of immune tolerance development may lead to infant immune maturing trajectory changing towards T2 predominance.

Objective. To conduct comparative evaluation of the allergenic activity of a proprietary extract and a commercial birch pollen allergen, and to characterize sensitization to pollen of Canadian goldenrod, ash-leaved maple, mountain pine and Scots pine, Norway spruce, and common juniper in patients with pollinosis.

Materials and methods. A study of 91 blood serum of patients with pollinosis (50 men – 55% and 41 women – 45%), average age 31 years old, was conducted. The study included the determination of specific immunoglobulins E by the immunoblotting method.

Results. Specific IgE antibodies to the extract of Canadian goldenrod (Solidago canadensis) were detected in 12 patients (13.3%), specific IgE antibodies to the extract of silver birch (Betula pendula) were detected in 55 patients (60%), and specific IgE antibodies to the extracts of scots pine (Pinus sylvestris) and ash-leaved maple (Acer negundo) were detected in 1 patient (1%).

Conclusion. The spectrum of sensitization is expanded by invasive species (Canadian goldenrod, Ash-leaved maple), as well as some rare species in terms of their ability to cause pollinosis (Scots pine).

Objective. To determine the specificity and sensitivity of the developed domestic enzyme-linked immunosorbent assay kit “ELISA-anti-HEV IgM” for detecting M class immunoglobulins to the hepatitis E virus (HEV) in human serum under real clinical conditions.

Materials and methods. To determine the sensitivity and specificity, we used registered industrial samples of the “ELISA-anti-HEV IgM” kit, produced by Unitary Enterprise “Pilot Production of the Institute of Bioorganic Chemistry National Academy of Sciences of Belarus” in accordance with TU BY 100185093.093-2023. 214 blood serum samples from patients with established presence of antibodies to hepatitis A virus, hepatitis C virus, hepatitis B virus antigen, hyperlipidemia, class M antibodies to cytomegalovirus and increased content of rheumatoid factor were examined on the basis of the clinical and diagnostic laboratory of the healthcare institution “City Clinical Infectious Diseases Hospital” of Minsk. To determine the sensitivity and specificity of the set, 72 serum samples were examined in parallel with reference sets “Vecto gep E-IgM”.

Results. When using the industrially released “ELISA-anti-HEV IgM” (TU BY 100185093.093-2023), the absence of non-specific cross-interaction between the sorbed recombinant polypeptides ORF2 and ORF3 of hepatitis E virus genotype 3 and proteins in samples of patients with antibodies to hepatitis C, hepatitis A, hepatitis B virus antigen, blood plasma with hemolysis and chylosis, samples with an increased content of rheumatoid factor and the presence of class M antibodies to cytomegalovirus. When evaluating sensitivity and specificity indicators on blood sera under real clinical conditions, high sensitivity indicators were established – at least 99% and specificity – at least 99%, which indicates the possibility of using the kit in the practical activities of laboratories of healthcare institutions.

Conclusion. The registered and manufactured first domestic test system for the determination of class M immunoglobulins against hepatitis E virus (HЕV) in human blood serum “ELISA-anti-HEV IgM” by indirect enzyme immunoassay has high analytical reliability: sensitivity is at least 99%, specificity is at least 99%,

Objective. To carry out a histological assessment of cellular and tissue reactions in response to the samples’ implantation of a woven vascular prosthesis with a new composition of antibacterial polymer coating in experiment.

Materials and methods. The study of cellular and tissue reactions was carried out on 30 laboratory white rats. Samples of a woven vascular prosthesis with a coating based on a polyvinyl-chitosan complex with L-asparagine acid and antibiotic vancomycin 1% without treatment (the first experimental group) and with corona discharge treatment (the second experimental group) were studied. In accordance with the study design, the animals were removed from the experiment on the 5th and 14th day, and 20th week of the postoperative period. Samples were taken for histological examination.

Results. In all experimental groups in the first days of the study (up to five days), the formation of granulation tissue was observed, which was undergoing formation and was the most active in the second experimental group in which samples with polymer coating after corona discharge treatment were studied. In the middle of the observation period (14th day), the granulation tissue had matured, and there were no differences between the experimental groups. Similarly, without statistical differences in all experimental groups at later stages (20 weeks), fibroplastic activity was observed, leading to the formation of dense, unformed connective tissue.

Conclusion. Experimental data have demonstrated that the treatment of woven vascular prostheses samples with a polymer coating based on a polyvinyl-chitosan complex with L-asparagine acid by corona discharge and exposure to 1% vancomycin solution for 30 minutes improves the process of granulation tissue formation on the 5th day after implantation in laboratory animals.

Objective. To assess the species and ecological structure of Coleoptera assemblages in forest ecosystems of the Yuzhno-Ostashkovichskoye oil field, associated with oil production sites.

Materials and methods. Field studies of beetle assemblages were conducted using formalin-coated soil traps (20 per field site) in five replicates. At sites with oil wells, the traps were arranged in a line, increasing in distance from the well waste edge. Calculation of means and their errors, one-way analysis of variance for abundance comparisons, were performed using the PAST 4.17 package. R (vegan and FSA packages) were used to determine alpha diversity indices and evaluate the significance of their differences. A cluster analysis of species similarity was constructed, and a species ranking chart was constructed using the BioDiversity Pro 2.0 package. Dominance in the assemblages was determined using the Renkonen scale. Species names and taxonomic order of ground beetles are given according to the Catalogue of Coleoptera of Belarus.

Results. A total of 985 Coleoptera specimens belonging to 93 species from 72 genera and 21 families were counted. The species composition and abundance of Coleoptera were determined in assemblages associated with oil wells and in a control site. No overall effect of assemblage location on Coleoptera abundance was revealed (H_K-W=2.46, p=0.253). At the same time, alpha diversity indices in the studied assemblages differed significantly both in communities associated with oil wells and in the control habitat (p<0.001). Overall, the studied assemblages were composed predominantly of forest meadow and field mesophiles and mesoxerophiles, zoophages and phytophages, and less frequently, mixophytophages.

Conclusion. The habitat conditions near boreholes contributed to the formation of more diverse and balanced communities compared to the control habitat. At the same time, the assemblages near oil wells exhibited a nearly complete reorganization of Coleoptera assemblages, which significantly differed in both species composition and ecological structure, as well as diversity parameters, compared to the natural forest habitat. This can be interpreted as a result of anthropogenic intervention.

Objective. To study morbidity and mortality in patients with comorbid pathologies during the period of increased incidence of respiratory infections.

Materials and methods. This study used data of a selective retrospective analysis of morbidity related to acute respiratory viral infections (ARVI). The main materials used in the epidemiological analysis were statistical data on morbidity and mortality rates for the period 2021-2023, including the outbreak of COVID-19 among patients assigned to provide medical care at the Gomel City Clinical Polyclinic No. 5 named after S.V. Golukhova. The study included 320 individuals. 2 groups were created — main and control ones. The study groups were comparable with respect to gender and age. Patients’ management was conducted from the onset of initial symptoms of ARVI till complete recovery or hospitalization. Pathogen determination in affected patients was performed using the polymerase chain reaction method at the Gomel Regional Center of Hygiene, Epidemiology and Public Health.

Results. The obtained results may have a crucial significance for predicting morbidity and mortality in patients with comorbid pathology at the level of outpatient clinics. It is necessary to carry out a quantitative assessment of the probability of complications and a fatal outcome when establishing cases of ARVI in patients with a burdened comorbid background.

Conclusion. ARVIs in patients with comorbid chronic somatic pathology are a high-risk situation. The study showed that, in general, the incidence of ARVI among the healthy population is 67.6% lower than in the main group (people with a history of diabetes and hypertension). The features of the pathogenetic effect of ARVI on patients with a burdened comorbid background contribute to an increased risk of complications and probability of death. The mortality rate among these patients is 28 cases per 160 studied, which is significantly higher than the control group. Taking into account standardization, the mortality rate in the main group will be 18.42%.

Thus, a multidisciplinary approach is needed to manage comorbid patients and predict an unfavorable clinical outcome during the period of an increase in the incidence of respiratory infections at the outpatient stage.

Objective. To determine and assess the impact of changes in the age structure on the level and dynamics of mortality among women of working age in the Republic of Belarus in 1990–2019.

Materials and methods. The study materials were data on the number and composition of living and deceased women of working age (hereinafter referred to as WWA) by five-year age groups in 1990–2019. To assess and analyze the studied indicators, linear and piecewise linear regression models of crude and standardized mortality rates by the method of direct standardization according to the age structure standard of WWA in 1990 were used. Based on the differences in the rates of annual mortality increase over the study period, expressed in %, a periodization of mortality dynamics in 1990–2019 of the studied population stratum was formed.

Results. A decrease in the number and aging of the female population of working age was established for the period 1990-2019, characterized by a decrease in the share of the younger (15-29 years) and an increase in the share of the middle (30-49 years) and older (50-64 years) age groups in the age structure. The change in the age structure factor did not affect the annual growth rate (hereinafter referred to as AGR) of WWA mortality in the periods of the mortality dynamics model, but led to an overestimation of mortality rates in 1990-1993 by up to 0.2‰. Since 2010, the overestimating effect on the WWA mortality rate has continued and by 2019 it amounted to 0.55‰, p<0.05.

Conclusion. The crude mortality rate of the female employable population, due to the ongoing transformation of its age structure, cannot serve as a target indicator in developing programs aimed at maintaining and strengthening the health of the employable population. When studying the level and dynamics of mortality of the age stratum of the female employable population, it is necessary to take into account the influence of the age structure factor on the indicators and dynamics of mortality.

Objective. To analyse the results of monitoring studies aimed at studying the features of non-poliomyelitis enteroviruses (NPEV) circulation in the Republic of Belarus in 2023-2024, with the presentation of data on their registration frequency among the population and in human habitats, spectrum, typical structure, regional prevalence in time and space.

Materials and methods. Over the observation period, 10 180 sanitary and virological studies (water samples of various types of use, food products, swabs from objects and objects of the human environment), and 50 726 diagnostic studies of biological material (blood serum samples, cerebrospinal fluid, nasopharyngeal swabs, feces) were conducted to identify markers of NPEV using methods of enzyme immunoassay (ELISA), polymerase chain reaction (PCR), cell culture and molecular genetic typing.

Results. It was found that in 2023-2024, the circulation of a wide range of NPEV was observed on the territory of the Republic of Belarus: Coxsackie A1, Coxsackie A5, Coxsackie A9, Coxsackie B2, Coxsackie B4, Coxsackie B5, ЕСНО 6, ЕСНО 9, ЕСНО 11, ЕСНО 30. In the standard structure of NPEV, the group of Coxsackie B viruses prevailed (66%) with the dominance of the serotype Coxsackie B5, which proportion in 2023 was 43%, and in 2024 increased to 85%. The main etiological agents of EVI registered in the Republic in 2024 were Coxsackie B5, ЕСНО 30 and Coxsackie B2 viruses, which were associated with a slight increase in morbidity.

Conclusion. Based on the patterns of the dynamics of the EVI epidemic process in Belarus and the current situation in the world, it can be assumed that the predicted incidence rate in 2025 will not change significantly compared to the last two years.

Objective. To give a hygienic assessment of the diets of Belarusian State Medical University’s (BSMU) students regarding essential amino acids and some vitamins’ adequacy.

Materials and methods. First to five year students of BSMU aged 20-23 years old (n=63), who gave their oral consent to participate, were engaged in the study using a simple random sample. The data collected for evaluation have been made to arithmetical mean. The average daily protein intake in a diet was calculated according to the tables of chemical content of food, taking into account the loss under heating [15]. To determine the vitamin C body supply, a “tongue” test with a Tillman’s reagent was used, and the assessment of the vitamin A body supply was carried out by the method of determining the time of dark adaptation and color perception.

Results. Analysis of the actual nutrition of students showed that it was characterized by insufficient consumption of meat and meat products, fish and fish products, dairy products, vegetables and fruits. As a result of the analysis of the chronometric results of all activities of students, the average daily energy expenditure was found to be 2662,1±80,79 kcal, when the energy from food in the body is 2182,2±148,62 kcal. The correspondence between the amount of energy received by the body with food and the amount of daily energy expenditure was recorded in only 11.3±0.4% of students; energy deficit of more than 10% was recorded in 88.7±0.08% of cases. Based on the obtained results of the average daily energy costs of respondents, physiological need for proteins was determined, which amounted to 79 g. Despite the fact that the share of energy value of diets due to proteins was 16.6%, the proteins in students’ diets are characterized as having limited value in terms of the content of essential amino acids, which reduces their digestibility. They consist of 5 limiting amino acids: methionine, histidine, tryptophan, threonine and lysine. The main limiting amino acids are methionine with cystine, whose amino acid ratio is 54%. Based on the data obtained, a reliable intake level for a protein mixture in this food diet is counted at 1,63 g per 1 kg of the body weight (BWT) of the eating.

Based on the data obtained, a reliable intake level for a protein mixture in dietary intake is counted at 1,6 g per 1 kg of the body weight (BWT) of the eating. An analysis of the food diet shows that the consumption deficit of mentioned essential amino acids is due to insufficient consumption of foods containing complete protein. These products include meat, fish, milk and dairy products as well as chicken eggs. When analyzing the diets, it was found that the content of some vitamins and minerals was below the required amount. Thus, the average intake of vitamin A was lower than the daily requirement among 96,2±0,05% of students, amounting to 473,5±13,09 mсg of retinol equivalent, corresponding to 47,4% of the physiological need. The results of the conducted study of the time of dark adaptation in conditions of weak (twilight) light showed an insufficient level of vitamin A supply. The average time of dark adaptation was 2 minutes 59 seconds, 60±0,3% of the study participants had a dark adaptation time within 1-2 minutes, and 40±0,3% had a dark adaptation time within 3-4 minutes. Daily average consumption of Vitamin В₁₂ among students was lower in 60±0,3% of cases, and was 2,37±0,66 mcg (79% of the physiological requirement). The average vitamin C requirement of students was 60,5±2,2 mg when consumed with diet 46,8±4,77 mg. The “tongue” test with Tillman’s reagent showed vitamin C body deficiency in 7,5±0,12% of students, the reagent color fading time on the tongue tip was 28-30 seconds.

Conclusion. The study showed that student’s nutritionis irrational and inadequate. The content of protein and essential amino acids, and vitamins in diets does not provide physiological needs of the body. In this regard, organization and nutritional status of students needs to be adjusted and improved. The actual nutrition of students in terms of energy value and nutrient composition is characterized as inadequate, it does not provide the body with complete protein and vitamins for its physiological needs.

Objective. To analyse current trends in the structure of disabling mental pathology among adult and child population of the Republic of Belarus for the period of 2015-2024 to identify key problems and ways to improve the system of psychiatric care, medical prevention and rehabilitation.

Materials and methods. The study is based on an analysis of data from 29 966 adults (18+) and 10 259 children (<18) newly recognized as disabled due to mental and behavioral disorders. Materials of the database of the Republican Information and Analytical System on Medical Assessment and Rehabilitation of Disabled Persons of the Republic of Belarus were used. Nosological groups are identified according to the 10th revision of the International Classification of Diseases.

Statistical processing was carried out using Microsoft Excel, absolute, relative and intensive indicators were calculated taking into account demographic data of the National Statistical Committee of the Republic of Belarus.

Results. The average annual level of primary disability related to mental and behavioral disorders was 3.96 per 10,000 people among the adult population of the Republic of Belarus. The largest proportion of disability falls on the age groups of 80-89 years old (29.8%), 70-79 years old (18.7%) and 60-69 years old (9.8%). The leading cause of primary disability is organic mental disorders (77.0% in 2024), mainly vascular and mixed dementia (49.0%), and Alzheimer’s disease (7.0%). Primary disability in this group increased over 10 years from 2254 cases in 2015 to 2652 in 2024. Vascular dementia predominates in the Republic of Belarus due to the high prevalence of cardiovascular diseases, late diagnosis, and influence of environmental factors and bad habits. Since 2019, the leading cause of primary disability in children is autism spectrum disorders (ASD). Over 10 years, the number of ASD cases has increased 6-fold (from 221 in 2015 to 1298 in 2024), and primary disability rates have increased from 1.38 to 6.32 per 10,000 children. The increase of disability among adults with ASD is projected to increase: by the end of 2023, 256 patients over the age of 18 were registered, 85% of whom have severe disabilities (I and II disability group).

Conclusion. The structure of disabling mental pathology in the Republic of Belarus is characterized with predominance of vascular dementia, that requires strengthen prevention of cardiovascular diseases and early prevention of cognitive disorders. Disabilities due to ASD are rapidly increasing in children, creating a need for the development of medical, social, and occupational rehabilitation programs for adult patients. Counteracting the identified trends is seen in the introduction of advanced diagnostic methods, prevention of cardiovascular diseases and promotion of a healthy lifestyle, development of a support system for patients with ASD at all stages of life. The obtained data are relevant for the adaptation of the State policy in the field of mental health and social protection.

Objective. To study the opinion of medical university students on perception of reproductive health in the youth environment.

Materials and methods. Sociological and statistical research methods were used in the study. An author questionnaire was developed. A survey of students of Belarusian State Medical University (n=98) was conducted. The Pearson’s test (χ²) was used to compare the study results. The results were statistically significant with an unerring probability of 95%.

Results. The survey revealed that 89.8% of respondents, regardless of physical activity level, considered their reproductive health within the context of the definition proposed by the World Health Organization as “a state of complete physical, mental and social well-being, and not merely the absence of disease or infirmity, in all matters relating to the reproductive system and its functions and processes”. The average rating of the positive impact of high performance sports on reproductive health was 5.9 points, while «amateur sports» received 7.7 points. Love and mutual respect were ranked by respondents as the primary reasons for starting a family. Most respondents indicated that both future mothers and fathers should adhere to a healthy lifestyle during preconception preparation.

Conclusion. According to the data of the conducted survey, medical students confirms the relevance of reproductive health issues and the motivation to promote a culture of health among future parents. Respondents demonstrated a high level of awareness regarding the interpretation of the term “reproductive health”, and the majority of them reported engaging in physical activity for more than 30 minutes daily.

Adrenal insufficiency is a relatively rare but serious disease characterized by decreased production of glucocorticoids and/or mineralocorticoids and adrenal androgens due to adrenal destruction or lack of its stimulation. This condition is characterized with subtle and rather nonspecific signs and symptoms that develop over weeks to months, and often go unnoticed, leading to delays in diagnosis [1]. A high level of clinical suspicion and diagnostic knowledge are required for diagnosis.

The article presents a clinical case of primary chronic adrenal cortex insufficiency in a middle-aged patient. An analysis of literary sources, clinical data, and laboratory test results was performed.

Objective. To summarize practical experience of networking cooperation upon implementation of higher and secondary medical educational programs.

Materials and Methods. The literature review was conducted, a survey of participants involved in networking cooperation was conducted followed by results processing. 52 medical college students and 36 university students participated in the survey.

Results. Collaborative activities between Gomel State Medical University (GomSMU), Mozyr State Medical College, and Babruysk State Medical College were implemented in the form of networking cooperation. The emphasis was placed on practice- and oriented learning, and attention was given to the acquisition of practical skills and teamwork. Training sessions were organized at the GomSMU simulation and assessment center, using modern simulators for cardiopulmonary resuscitation, auscultation, taking an electrocardiogram, as well as the “Virtual Patient” simulator [1]. The student volunteer team “Kolibri” took active part in implementation of educational programs, that provided exchange of experience and support in training. This approach enabled participants to strengthen sustainable practical skills, leadership skills, and medical judgments, as well as promote vocational guidance. The survey confirmed the high effectiveness of joint activities in preparing future healthcare professionals.

Conclusion. The work results showed the value of networking cooperation. Implementation of join training sessions and practical classes contributed to strengthening team and communicative skills of trainees, foster motivation for professional growth, that will ultimately have a positive impact on the level of training of personnel for the healthcare system.

Objective. To evaluate the results of implementing an organizational model of early detection, diagnosis and treatment of pharyngeal mycosis associated with respiratory diseases.

Materials and methods. Evaluation of the implementation of an organizational model for providing medical care to patients with pharyngeal mycosis associated with respiratory diseases was conducted from September to December 2025 at the clinical base of the Dobrush Central District Hospital (hereinafter referred to as DCDH). The model includes an organizational algorithm of medical measures for early detection and diagnosis of pharyngeal mycosis in accordance with the joint order “On Improving Measures for Early Detection and Diagnosis of Pharyngeal Mycosis” issued by Gomel State Medical University (GomSMU) No. 350, and the Main Department of Healthcare of the Gomel Regional Executive Committee (MDH) No. 1031 dated July 22, 2025, using the artificial intelligence (AI) clinical decision support system “FaringoBot”. Clinical methods (otolaryngological examination, pharyngoscopy, microbiological and microscopic examination of pharyngeal secretions), medico-sociological methods (sociological survey of healthcare workers, patient questionnaires), as well as methods of medical analysis and statistical data processing were applied to assess the results of the algorithm’s implementation in the pilot region.

Results. The organizational model has been introduced and successfully implemented in the pilot region. This model includes the organizational algorithm “Algorithm of Organizational Measures for Early Detection and Diagnosis of Pharyngeal Mycosis Associated with Respiratory Diseases” utilizing the AI-powered clinical decision support system assistant “FaringoBot”.

Conclusion. The pilot project has demonstrated successful implementation and execution of the organizational model that includes organizational algorithm for medical treatments for early detection and diagnosis of pharyngeal mycosis, using the intelligent clinical decision support system AI assistant “FaringoBot” in medical practice expressed with statistically significant indicators in clinical practice. This organizational model was approved by the medical community.