The Roles of Melf Patterns, the Depth of Invasion and Number of Tumor Emboli as the Predictive Factors of the Survival Rate Among Patients with Endometrioid Adenocarcinoma of the Corpus Uterus
https://doi.org/10.51523/2708-6011.2019-16-1-10
Abstract
Objective: to determine the prognostic significance of MELF patterns, the depth of tumor invasion and number of tumor emboli in order to predict the survival rate of patients with endometrioid adenocarcinoma. Mаteriаl аnd methods. The study included 60 female patients. The presence/absence of MELF patterns, the depth of invasions and number of tumor emboli in stromal vessels were assessed. The groups were compared using the Mann-Whitney test. The threshold values were determined using the ROC-analysis. The survival rate was analyzed using the Log-rank test. Results. Statistically significant differences in the above parameters were found in the groups with different disease outcomes. The values of the threshold indicators reflecting the negative disease outcome, as well as the differences in the survival rate of the patients based on the threshold values were determined. Conclusion. The presence of MELF patterns (p = 0.0018), the depth of tumor invasion into the myometrium > 54.1 % (p < 0.001), the number of tumor emboli more than 6.7 to 1 mm2 (p < 0.001) more often are indicative of a low overall survival rate.
About the Author
D. A. Zinovkin
Учреждение образования «Гомельский государственный медицинский университет»
Belarus
Belarus
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Review
For citations:
Zinovkin D.A. The Roles of Melf Patterns, the Depth of Invasion and Number of Tumor Emboli as the Predictive Factors of the Survival Rate Among Patients with Endometrioid Adenocarcinoma of the Corpus Uterus. Health and Ecology Issues. 2019;(1):49-53. (In Russ.) https://doi.org/10.51523/2708-6011.2019-16-1-10
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