CONDITION OF SECONDARY HEMOSTASIS IN CHILDREN WITH PURPURA RHEUMATICA
https://doi.org/10.51523/2708-6011.2010-7-2-2
Abstract
There was performed the incidence analysis of purpura rheumatica among children aged 3-16 for the period of January, 2005 - January, 2009. For the analyzed period there were diagnosed 42 cases. Children aged 6-13 are mostly the purpura rheumatica disease inclined (65 %), the girls and boys become ill with identical frequency. The acute course was registered in 66,7 % of cases. More often the isolated skin form is developed (38 %), light and average disease severity (88,5 %). The secondary hemostasis condition in children with purpura rheumatica is charachterized by mixed changes: hypocoagulation by activated partial thromboplastin time, by thrombin time and prothrombin index; hypercoagulation by fibrinogen level and INR. Changes in coagulogram and degree of their expressiveness depend on the clinical form of disease, severity level and variant of course.
About the Authors
S. A. Hoduleva
Gomel State Medical University
Belarus
Belarus
I. P. Romashevskaya
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
A. N. Demodenko
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
D. K. Novik
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
G. Yu. Borodina
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
T. I. Kireeva
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
O. V. Zhuk
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
References
1. Зиновьева, Г. А. Геморрагический васкулит у детей: клиника и лечение/ Г. А. Зиновьева // Российский педиатрический журнал. - 1998. - № 1. - С. 24-26.
2. Кувшинников, В. А. Геморрагический васкулит у детей / В. А. Кувшинников // Белорусский медицинский журнал. - 2004. - № 3. - С. 12-16.
3. Геморрагический васкулит у детей: учебно-методическое пособие / Т. И. Козарезова [и др.], под ред. Т. И. Козарезовой. - Мн.: БелМАПО, 2007. - С. 39.
4. Brendel-Muller, K. Laboratory signs of activated coagulation are common in Henoch-Schönlein purpura / К. Brendel-Muller // Pediatric Nephrology. - 2001. - Vol. 16. - P. 1084-1088.
5. Role of mesangial fibrinogen deposition in the pathogenesis of crescentic Henoch-Schönlein nephritis in children / J. I. Shin [et al.] // Journal of Clinical Pathology. - 2005. - Vol. 58. - Р. 1147-1151.
6. Smith, G. C. Complement activation in Henoch-Schönlein purpura / G. C. Smith // Pediatric Nephrology. - 1997. - Vol. 11. - P. 477-480.
7. Henoch-Schönlein purpura / E. J. Tizard [et al.] // Archives of Disease in Childhood. - 1999. - Vol. 80. - Р. 380-383.
8. Topaloglu, R. Vascular endothelial growth factor in Henoch-Schönlein purpura / R. Topaloglu // Journal of Rheumatology. - 2001. - Vol. 28. - Р. 2269-2273.
Review
For citations:
Hoduleva S.A., Romashevskaya I.P., Demodenko A.N., Novik D.K., Borodina G.Yu., Kireeva T.I., Zhuk O.V. CONDITION OF SECONDARY HEMOSTASIS IN CHILDREN WITH PURPURA RHEUMATICA. Health and Ecology Issues. 2010;(2):11-16. (In Russ.) https://doi.org/10.51523/2708-6011.2010-7-2-2
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