ESTIMATION OF GENETIC PREDISPOSITION TO BREAST CANCER BY TESTING OF MOST FREQUENT MUTATIONS OF BRCA1 AND BRCA2 GENES IN GROUP OF PATIENTS FROM GOMEL REGION OF BELARUS
https://doi.org/10.51523/2708-6011.2009-6-4-20
Abstract
The work that has been carried out describes for the first time the hereditary caused breast cancer cases in Gomel region of Belarus, having defined a spectrum and frequencies of the most significant genetic factors underlying the given pathology. After the molecular-genetic testing of 667 primary breast cancer cases it was shown that out of eight BRCA1/2 gene mutations that are widely spread in Eastern Europe there are only five ones in Gomel region of Belarus with various frequencies - 185delAG, 300T>G, 4153delA, 5382insC and 6174delT. The 2274insA, 3819del5 and 3875del4 mutations were not found in the studied group. The 5382insC mutation was found to be the predominant one, which has made 80 % of all the detected mutations. Total mutation frequency in nonselective sampling taking into consideration the standardized indicators of age structure has made 7,9 %. It was found out, that family anamnesis is the most significant criterion from the point of view of probability estimation of BRCA1/2 mutations in genotype. In the united subgroup of patients with any of the basic signs of family cancer and their combinations, the share of mutations has made 24,4 %.
About the Authors
A. E. Silin
Republican Research Center for Radiation Medicine and Human Ecology
Belarus
Belarus
V. N. Martinkov
Republican Research Center for Radiation Medicine and Human Ecology
Belarus
Belarus
D. B. Rodjko
Republican Research Center for Radiation Medicine and Human Ecology
Belarus
Belarus
E. A. Nadyrov
Republican Research Center for Radiation Medicine and Human Ecology
Belarus
Belarus
S. M. Martynenko
Gomel Regional Clinical Oncologic Dispensary
Belarus
Belarus
I. B. Tropashko
Gomel Regional Clinical Oncologic Dispensary
Belarus
Belarus
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Review
For citations:
Silin A.E., Martinkov V.N., Rodjko D.B., Nadyrov E.A., Martynenko S.M., Tropashko I.B. ESTIMATION OF GENETIC PREDISPOSITION TO BREAST CANCER BY TESTING OF MOST FREQUENT MUTATIONS OF BRCA1 AND BRCA2 GENES IN GROUP OF PATIENTS FROM GOMEL REGION OF BELARUS. Health and Ecology Issues. 2009;(4):100-107. (In Russ.) https://doi.org/10.51523/2708-6011.2009-6-4-20
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