THE FAECAL MARKER OF CROHN`S DISEASE
https://doi.org/10.51523/2708-6011.2009-6-3-19
Abstract
Research aim: to study the diagnostic amount of faecal stoolproctine in revealing Crohn`s disease. During the research have been examined 14 patients, suffering from Crohn`s disease and 137 patients without any inflammatory or oncologic bowels pathology. It has been ascertained, that the faecal stoolproctine exceeds the immunochemical test, which revels latent blood in stool, also S-reactive albumen and erythrocyte sedimentation rate in the diagnostic amount (ППК: 0,94, СО: 0,05; ППК: 0,73, СО: 0,08; ППК: 0,71, СО: 0,09; ППК: 0,72, СО: 0,08 accordingly, р < 0,05). The marker sensitivity in revealing Crohn`s disease at the cutting off point of 75,18 mkg/g was 92,31 % (95 % ДИ: 63,90-98,70) and specifity - 95,49 % (95% ДИ: 90,40-98,30).
About the Authors
E. I. Mihailova
Gomel State Medical University
Belarus
Belarus
T. V. Satirova
Gomel State Medical University
Belarus
Belarus
References
1. Лечение болезни Крона у взрослых // Рекомендации Американской коллегии гастроэнтерологов [Электронный ресурс]. - 2001. - Режим доступа: http://practica.ru/SMM/0104/0104part6.pdf - Дата доступа: 12.07 2008.
2. Calprotectin is a stronger predictive marker of relapse in ulcerative colitis than in Crohn’s disease / F Costa [et al.] // Gut. - 2005. - Vol. 54, № 3. - Р. 364-368.
3. Konikoff, M. R. Role of fecal calprotectin as a Biomarker of intestinal inflammation in Inflammatory Bowel Disease / M. R. Konikoff // Inflamm. Bowel Dis. - 2006. - Vol. 12. - Р. 524-534.
4. Johne, B. New fecal calprotectin test for colorectal neoplasia. The Clinical results and comparison with preceding method / В. Johne // Scand. J. Gastroenterol. - 2001. - № 36. - Р. 291-296.
5. Limburg, P. J. The Level Faecal Calprotectin predict colorectal inflammation amongst patient with chronic diarrheoa ed for colonoscopy / P. J. Limburg // J. Gastroenterol. - 2000. - № 95. - Р. 2831-2837.
6. Diagnostic accuracy of faecal calprotectin estimation in prediction of abnormal small bowel radiology / S. Dolvani [et al.] // Alimentary Pharmacology & Therapeutics. - 2004. - № 20(6). - Р. 615-621.
7. Diagnostic precision of fecal calprotectin for inflammatory bowel disease and colorectal malignancy / А.С. Roon [et al.] // Database of Abstracts of Reviews of Effects (DARE). - [Electronic resource]. - 2008. - Mode of access: http://www.crd.york.ac.uk/ CRDWeb/ShowRecord.asp?View=Full&ID=12007001290. - Date of access: 08.08.2008.
Review
For citations:
Mihailova E.I., Satirova T.V. THE FAECAL MARKER OF CROHN`S DISEASE. Health and Ecology Issues. 2009;(3):83-89. (In Russ.) https://doi.org/10.51523/2708-6011.2009-6-3-19
Views: 254
Email this article 