EXPRESSION MUTANT P53 DEPENDING ON CHEMOSENSITIVITY OF WIDE-SPREAD FORMS OF OVARIAN CANCER
https://doi.org/10.51523/2708-6011.2009-6-2-6
Abstract
Negotiation of chemoresistance by means of molecular target biomarkers for the use of more effective drugs is a relevant problem of modern oncogynaecology. The aim of study is to research the level of p53 expression advanced ovarian cancer. The study group consisted of 80 advanced ovarian cancer patients which underwent medical treatment in National Cancer Center of N.N. Alexandrov of Belarus from 1999 to 2002 year. Identification of p53 expression was carried out with immunohistochemistry. P53 expression was revealed in 61,3 % of cases, meanwhile 67,3 % of chemoresistant cases and in 38,8 % chemosensitive cases. In two studies groups differences in density of staining, quantity p53 staining cells in point system, amount of points (Score) and also ultimate number of staining cells (p < 0,05, Mann-Whitney test) are statistically significant. The level of p53 expression is high in serous, endometrial and undifferent forms of chemoresistant group ovarian cancer.
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Review
For citations:
Moysey A.V. EXPRESSION MUTANT P53 DEPENDING ON CHEMOSENSITIVITY OF WIDE-SPREAD FORMS OF OVARIAN CANCER. Health and Ecology Issues. 2009;(2):30-34. (In Russ.) https://doi.org/10.51523/2708-6011.2009-6-2-6
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