INFLAMMATION MARKERS AT PREMATURE RUPTURE OF AMNIOTIC MEMBRANES
https://doi.org/10.51523/2708-6011.2009-6-1-16
Abstract
Purpose: reveale role: lactoferrin, interferon-ά, interferon-γ, interleukin-1β, receptor antagonist interleukin-1β at premature rupture amniotic membranes. Material and method: ELISA detected concentration of lactoferrin, interferon-ά, interferon-γ, interleukin-1β, receptor antagonist interleukin-1β in peripheral blood, umbilical blood, amniotic fluid. Statistica: Mann-Whitney Т & U-test, Spearman rank, calculation median, odds ratio and confidence interval. Results: аt premature rupture amniotic membranes lactoferrin in peripheral blood is lower (р < 0,005), and IL-1β - is higher (р < 0,02), than at duly. At duly rupture RA-IL-1β concentration in amniotic fluid is increased in comparison with umbilical (р < 0,001) and mather’s blood (р < 0,001). The increase in duration waterless interval raises ά-IF (р = 0,05) level and is reduced lactoferrin (р = 0,02) in umbilical blood.
About the Authors
I. A. Korbut
Gomel State Medical University
Belarus
Belarus
E. I. Baranovskaja
Gomel State Medical University
Belarus
Belarus
E. V. Voropayev
Gomel State Medical University
Belarus
Belarus
L. G. Barry
Gomel State Medical University
Belarus
Belarus
N. M. Golubyh
Gomel State Medical University
Belarus
Belarus
References
1. Макаров, О. В. Современные представления о внутриутробной инфекции / О. В. Макаров, И. В. Бахарева, А. Н. Таранец // Акушерство и гинекология. - 2004. - № 1. - С. 10-12.
2. Shobokshi, А. Maternal serum and amniotic fluid cytokines in patients with preterm premature rupture of membranes with and without intrauterine infection / А. Shobokshi, M. Shaarawy // International Journal of Gynecology & Obstetrics. - 2002. - Vol. 79, № 3. - P. 209-215.
3. Yan, W.-H. Immunological aspects of human amniotic fluid cells: Implication for normal pregnancy / W.-H. Yan // Cell Biology International. - 2008. - Vol. 32, № 1. - P. 93-99.
4. Currya, A. Maternal plasma cytokines in early- and mid-gestation of normal human pregnancy and their association with maternal factors / A. Currya // Journal of Reproductive Immunology. - 2008. - Vol. 77, № 2. - P. 152-160.
5. Inflammatory processes in preterm and term parturition / I. Christiaens [et al.] // Journal of Reproductive Immunology. -2008. - Vol. 79, № 9. - P. 50-57.
6. Lactoferrin in intrauterine infection, human parturition, and rupture of fetal membranes / P. Pacora [et al.] // American Journal of Obstetrics and Gynecology. - 2000. - Vol. 183, № 4. - P. 904-910.
7. Preventive effect of recombinant human lactoferrin in a rabbit preterm delivery model / A. Hasegawa [et al.] // American Journal of Obstetrics and Gynecology. - 2005. - Vol. 192, № 4. - P. 1038-1043.
8. Чернуха, Е. А. Родовой блок: рук-во для врачей / Е. А. Чер-нуха. - 3-е изд. - М.: «Триада Х», 2003. - С. 65-76.
Review
For citations:
Korbut I.A., Baranovskaja E.I., Voropayev E.V., Barry L.G., Golubyh N.M. INFLAMMATION MARKERS AT PREMATURE RUPTURE OF AMNIOTIC MEMBRANES. Health and Ecology Issues. 2009;(1):78-83. (In Russ.) https://doi.org/10.51523/2708-6011.2009-6-1-16
Views: 269
Email this article 