COMPARATIVE CLINICAL MORPHOLOGICAL DESCRIPTION OF CHRONIC VIRAL HEPATITIS B WITH THE PERSISTENCE OF HERPETIC INFECTION IN THE LIVER AND WITHOUT IT

Abstract

Severe fibrous changes are established to appear more often in case of the persistence of herpetic infection in the liver; inflammatory infiltration of portal tracts without any difference in its structure is more manifested, as well as polymorphism of hepatocytes and their nuclei with more frequent combination of moderate cellular polymorphism and marked nuclear polymorphism in compare with chronical hepatitis B without the persistence of herpetic infection in the liver. At the same time poor and moderate polymorphism of hepatocytes and their nuclei develop more frequently in case of chronic hepatitis B without the persistence of herpetic infection in the liver. There are no established differences between men and women in two study groups according to all clinical and morphological characteristics. The persistence of herpetic infection in case of chronical hepatitis B is considered as a chronical slowly progressive infection with a flaccid course because of the absence of established differences in morphological and laboratory characteristics and of inflammatory activity between chronical hepatitis B with the persistence of herpetic infection in the liver and chronical hepatitis B without the persistence of herpetic infection in the liver, as well as the presence of intranuclear herpetic II type - inclusions and more frequent development of severe fibrous changes.