THE FREQUENCY OF HFE GENE MUTATIONS C282Y AND H63D REVEALING IN PATIENTS WITH CHRONIC HEPATITIS AND LIVER CIRRHOSIS OF DIFFERENT ETIOLOGY
https://doi.org/10.51523/2708-6011.2008-5-2-12
Abstract
The revealing of HFE gene mutations C282Y and H63D in 31 patients with chronic hepatitis and liver cirrhosis of different etiology was studied. Mutations were associated more often with male sex (52.9%) vs. female (21.4%) and alcohol abusing (46.2%) vs. non-drinkers (33.3%). In persons with mutations response to interferon therapy was poorer and fibrosis predominated over inflammation in liver bioptates.
About the Authors
V. M. Mitsura
Gomel State Medical University
Belarus
Belarus
T. L. Krasavtsev
Gomel State Medical University
Belarus
Belarus
E. V. Voropaev
Gomel State Medical University
Belarus
Belarus
O. Yu. Baranov
Gomel State Medical University
Belarus
Belarus
I. V. Paltsev
Gomel State Medical University
Belarus
Belarus
A. L. Kalinin
Gomel State Medical University
Belarus
Belarus
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Review
For citations:
Mitsura V.M., Krasavtsev T.L., Voropaev E.V., Baranov O.Yu., Paltsev I.V., Kalinin A.L. THE FREQUENCY OF HFE GENE MUTATIONS C282Y AND H63D REVEALING IN PATIENTS WITH CHRONIC HEPATITIS AND LIVER CIRRHOSIS OF DIFFERENT ETIOLOGY. Health and Ecology Issues. 2008;(2):56-62. (In Russ.) https://doi.org/10.51523/2708-6011.2008-5-2-12
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