THE BRAFT1796A TRANSVERSION IS A PREVALENT MUTATIONAL EVENT IN HUMAN THYROID MICROCARCINOMA
https://doi.org/10.51523/2708-6011.2006-3-1-5
Abstract
The results show that BRAFT1799A mutation is a prevalent event in human thyroid microcarcinomas irrespectively of the genetic background of adult patients. Mutated BRAF might be involved in the control of tumors architecture and growth pattern but its presence does not correlate with manifestations of papillary microcarcinomas (PMC) aggressiveness. Whereas BRAF mutation comprise a common genetic alteration in conventional papillary thyroid carcinoma (PTC) and PMC, a number of differences in mutation-related associations between the two types of tumors rather supports the hypothesis that not all macroscopic PTCs may arise from papillary microcarcinoma.
About the Authors
I. . Sedliarou
Departments of Molecular Medicine, International Health and Radiation Research, Tissue and Histopathology Section, Department of Biomedical Statistics, Atomic Bomb Disease Institute, Nagasaki University Graduate
Belarus
Belarus
V. . Saenko
School of Biomedical Sciences Clinical-Morphological Department, Medical Radiological Research Center RAMS
Belarus
Belarus
T. . Rogounovitch
School of Biomedical Sciences Clinical-Morphological Department, Medical Radiological Research Center RAMS
Belarus
Belarus
H. . Namba
School of Biomedical Sciences Clinical-Morphological Department, Medical Radiological Research Center RAMS
Belarus
Belarus
A. . Abrosimov
School of Biomedical Sciences Clinical-Morphological Department, Medical Radiological Research Center RAMS
Belarus
Belarus
E. . Lushnikov
School of Biomedical Sciences Clinical-Morphological Department, Medical Radiological Research Center RAMS
Belarus
Belarus
M. . Matsuse
Department of Pathology, Nagasaki University Hospital
Belarus
Belarus
A. . Kumagai
Department of Pathology, Nagasaki University Hospital
Belarus
Belarus
M. . Nakashima
Department of Pathology, Nagasaki University Hospital
Belarus
Belarus
S. . Meirmanov
Department of Pathology, Nagasaki University Hospital
Belarus
Belarus
T. . Hayashi
Department of Pathology, Nagasaki University Hospital
Belarus
Belarus
M. . Mine
Department of Pathology, Nagasaki University Hospital
Belarus
Belarus
S. . Yamashita
Department of Pathology, Nagasaki University Hospital
Belarus
Belarus
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Review
For citations:
Sedliarou I., Saenko V., Rogounovitch T., Namba H., Abrosimov A., Lushnikov E., Matsuse M., Kumagai A., Nakashima M., Meirmanov S., Hayashi T., Mine M., Yamashita S. THE BRAFT1796A TRANSVERSION IS A PREVALENT MUTATIONAL EVENT IN HUMAN THYROID MICROCARCINOMA. Health and Ecology Issues. 2006;(1):31-34. (In Russ.) https://doi.org/10.51523/2708-6011.2006-3-1-5
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