Local therapy of knee osteoarthritis with the medical device “Plasma enriched with soluble platelet factors, autologous”

Objective. To evaluate efficiency of intra-articular administration of the medical device “Plasma enriched with soluble platelet factors, autologous” (MD “PRP autologous”, registration number Mn-7.1198917-2009) in patients with knee osteoarthritis.

Materials and methods. Patients with knee osteoarthritis (KA) received treatment with three intra-articular injections of MD “PRP autologous”. Clinical and functional status of patients was assessed using the visual analogue scale (VAS), WOMAC, Likert, and Leken scales. The levels of pro-inflammatory (IL-1, IL-6) and anti-inflammatory (IL-4, IL-10) interleukins were determined in 2 weeks, 4 weeks, and 6 months after the start of treatment. Ultrasound examination of the knee joints was performed before the start of treatment and 6 months after the administration of MD “PRP autologous”.

Results. A statistically significant reduction in pain syndrome (WAS scale) was observed between the baseline level before treatment and 4-week and 6-month follow-up periods. A statistically significant improvement in the functional status of patients’ knee joints on the WOMAC scale was noted between baseline and 4 weeks, on the Leken scale, a decrease in this indicator between baseline and 4 weeks and between baseline and 6 months, and a decrease in the Likert scale between the baseline and 4 weeks was noted. The anti-inflammatory effect was expressed in a statistically significant decrease in IL-6 and IL-10 levels 6 months after the start of treatment, and their levels at the intermediate stages of treatment at 2 weeks and 4 weeks. Stabilization of the thickness of the articular cartilage in various sections of the femur and tibia after 6 months was established in the range from 64.71% to 88.24%.

Conclusion. The conducted study showed that intra-articular administration of MD “PRP autologous” led to a reduction in pain syndrome, improvement in the functional state of the knee joint, anti-inflammatory effect, and stabilization of joint cartilage thickness. The data obtained indicate a positive effect of treatment with MD “PRP autologous” in patients with KA of the knee joints.

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