Congenital liver cirrhosis as a manifestation of neonatal hemochromatosis
https://doi.org/10.51523/2708-6011.2026-23-1-16
Abstract
Neonatal hemochromatosis (NH) is one of the phenotypic manifestations of gestational alloimmune liver disease (GALD). In this pathology, due to fetomaternal isoimmunization, the production of IgG antibodies against fetal hepatocytes occurs. As a result of the interaction between fetal liver antigens and mothers antibodies, hepatocyte damage and apoptosis develop. The clinical symptoms of GALD are diverse and most often manifest in a form of neonatal hemochromatosis. There is a clinical and laboratory picture of acute liver failure with hemorrhagic syndrome due to coagulopathy, hypoglycemia, hypoalbuminemia with the development of edema syndrome. The discovery of the alloimmune nature of this pathology has made it possible to develop a more effective treatment method using exchange blood transfusion and intravenous administration of immunoglobulin at a dose of 1g/kg, which has increased the survival rate of newborns to 75%. In this regard, it is important for obstetricians, gynecologists and neonatologists to be aware of the mechanisms of this pathology, its clinical picture, and possible treatment methods.
About the Author
L. V. Krivitskaya
Gomel State Medical University
Belarus
Belarus
Lyudmila V. Krivitskaya, Candidate of Medical Sciences, Associate Professor, Associate Professor at the Department of Pediatrics with a course of Advanced Training and Retraining
Gomel
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Review
For citations:
Krivitskaya L.V. Congenital liver cirrhosis as a manifestation of neonatal hemochromatosis. Health and Ecology Issues. 2026;23(1):134-140. (In Russ.) https://doi.org/10.51523/2708-6011.2026-23-1-16
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