Development of a new composition of an antibacterial polymeric coating for modification of a woven vascular prosthesis

Objective. To develop a new composition of an antibacterial polymeric coating for modifying a woven vascular prosthesis in an experiment.

Materials and methods. Experimentally determined mechanical and antibacterial resistance, cellular and tissue reactions of modified woven vascular prostheses with a hydrogel coating from polyvinyl alcohol, polyvinylpyrrolidone, chitosan, hyaluronic acid and the antibiotic vancomycin (1%); samples of woven vascular prostheses with a hydrogel coating from polyvinyl alcohol, polyvinylpyrrolidone, chitosan, L-aspartic acid and an antibiotic Vancomycin (1%); samples of woven vascular prostheses with a hydrogel coating of polyvinyl alcohol, chitosan, L-aspartic acid and the antibiotic Vancomycin (1%).

Results. Evaluation of mechanical stability and evaluation of duration of antibacterial resistance of modifications revealed that the presence of L-aspartic acid inhances resistance to leaching of Vancomycin (1%) from the polyvinyl chitosan coating and increases the duration of antibacterial resistance of the prosthesis compared with hyaluronic acid from 4 to 5 days. Evaluation of cellular and tissue reactions shows that the addition of polyvinylpyrrolidone into a coating based on a polyvinyl-chitosan complex with L-aspartic acid reduces the rate of transformation of granulation tissue into coarse-fibrous connective tissue.

Conclusion. It was experimentally determined that the best tested antibacterial polymeric coating for modification of woven vascular prostheses is a combination of polyvinyl alcohol, chitosan, and L-aspartic acid after soaking in a 1% solution of Vancomycin for 30 minutes.

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