Dynamics of indicators of systemic inflammatory response in patients with brain death

Objective. To study the dynamics of levels of complete blood cell count (CBC) and C-reactive protein (CRP) in donors with brain death.

Materials and methods. The prospective study included 106 organ and/or tissue donors with brain death, who received intensive care in the Anesthesiology and Resuscitation Department of Mogilev Region from January 1, 2020 to November 1, 2023.

Results. In deceased donors, from days 1 to 4 of intensive therapy, there was a statistically significant increase in erythrocyte sedimentation rate (ESR) and C-reactive protein. The level of CRP in the 1^st day was equal to 13.3 (3.86; 29.1) mg/l, 2nd day – 85 (45.4; 140.6) mg/l (p < 0.0001 vs 1d), 3^rd day – 135 .3 (73.6; 238.2) mg/l (p < 0.0001 vs 2d),4^th day – 219.7 (112.7; 326.4) mg/l (p < 0.0001 vs 3d). At 5-7 days the level of CRP did not change statistically significantly. Donors with pneumonia had a statistically significant increase in band neutrophils, ESR and temperature compared to patients without this infection. At the same time, the level of CRP did not differ in these groups of donors without and with pneumonia: 134.5 (56; 261.5) mg/l and 145.6 (95.4; 268) mg/l, respectively (p = 0.4).

Conclusion. C-reactive protein in brain-dead donors can be used as an additional quantitative measure of the extent of brain damage and the severity of the systemic inflammatory response.

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