Chemical and natural substances for protection against radiation
https://doi.org/10.51523/2708-6011.2024-21-4-02
Abstract
Priority research in the field of radiation biology and medicine remains the search for new effective anti-radiation substances, since the protection of the human population from radiation damage is one of the issues of state security. The first medicament preparations obtained from classes of aminothiols and indolylamines can reduce primary radical processes and are used as preventive agents. Natural polyphenol substances, which are used in the clinic to improve the recovery of patients after radiation therapy, were obtained to block the formation of secondary radicals of biological molecules in the body after irradiation. Subsequently, with the discovery of intercellular regulators – cytokines, it became possible to develop effective therapeutic regimens to stimulate critical systems of the body in the treatment of radiation sickness. In Russia, the first anti-radiation drug based on the recombinant cytokine interleukin-1 was recently developed. The required chemically stable and easy to use anti-radiation agent can be created on the basis of DNA. Laboratory studies have shown that the introduction of exogenous DNA into the body after irradiation increases its survival by creating conditions for proper DNA repair in cells of critical tissues. This allows us to consider the DNA substance very promising for the development on its basis of a new anti-radiation drug.
Supporting agencies: Funding. None.
About the Authors
A. V. Litvinchuk
Gomel State Medical University
Belarus
Belarus
Alexandra V. Litvinchuk, Candidate of Chemical Sciences, Associate Professor at the Department of Biological Chemistry
Gomel
O. S. Logvinovich
Gomel State Medical University
Belarus
Belarus
Olga S. Logvinovich, Candidate of Biological Sciences, Associate Professor, Head of the Department of Biological Chemistry
Gomel
A. O. Shpankov
Military and Medical Directorate of the Ministry of Defence of the Republic of Belarus
Belarus
Belarus
Alexander O. Shpankov, Lieutenant Colonel of the Medical Service, Deputy Head of the Military and Medical Directorate
Minsk
O. V. Dokhov
Gomel State Medical University
Belarus
Belarus
Oleg V. Dokhov, Lieutenant Colonel of the Medical Service, Deputy Head of the Military Department
Gomel
N. S. Myshkavets
Gomel State Medical University
Belarus
Belarus
Nadeja S. Myshkavets, Lecturer at the Department of Biological Chemistry
Gomel
E. M. Belous
Gomel State Medical University
Belarus
Belarus
Ekaterina M. Belous, Lecturer at the Department of Biological Chemistry
Gomel
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Review
For citations:
Litvinchuk A.V., Logvinovich O.S., Shpankov A.O., Dokhov O.V., Myshkavets N.S., Belous E.M. Chemical and natural substances for protection against radiation. Health and Ecology Issues. 2024;21(4):16-25. (In Russ.) https://doi.org/10.51523/2708-6011.2024-21-4-02
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