Preview

Health and Ecology Issues

Advanced search

Clinical observation of a patient with mixed connective tissue disease in an outpatient practice

https://doi.org/10.51523/2708-6011.2024-21-1-16

Abstract

   Systemic connective tissue diseases are a heterogeneous group of diseases with unclear etiology, the pathogenesis of which is represented by an autoimmune process, a heterogeneous clinical picture and a variable course. Classical variants of the disease that do not cause difficulties in their verification are most common in clinical practice. But some patients have signs characteristic of various connective tissue diseases. This combination of symptoms is called mixed connective tissue disease or “cross syndrome” (Overlap-syndrome). The multi-organ nature of the clinical picture of the disease presents a diagnostic difficulty for the clinician and leads to late diagnosis, ineffective therapy, and disability of the patient. The article presents a clinical case of mixed connective tissue disease in a middle-aged patient. An analysis of literary sources, clinical data, and laboratory results was carried out.

About the Authors

N. N. Spoda
Gomel University Clinic - regional hospital for disabled people of the Great Patriotic War
Belarus

Natalya N. Spoda, Head of the Department

Therapeutic Department No. 2

Gomel



O. L. Nikiforova
Gomel State Medical University
Belarus

Olga L. Nikiforova, Senior Lecturer

Department of Outpatient Therapy and General Medicine with the course of the Faculty of Professional Development and Retraining

Gomel



D. S. Gorbach
Gomel State Medical University
Belarus

Darya S. Gorbach, Student

Medical Faculty of group 518

Gomel



N. V. Lin
Gomel State Medical University
Belarus

Nikolay V. Lin, Student

Medical Faculty of group 518

Gomel



References

1. Bubnevich TE, Zaryankina AI, Ivkina SS. Systemic diseases of connective tissue in children and adolescents : educational method a manual for 4-6 year students of all faculties of higher medical education institutions, subordinate pediatricians, general practitioners, pediatricians, cardio-rheumatologists, students of advanced training and retraining courses. Gomel: GomSMU, 2018. 52p. [date of access 2024 January 07]. Available from: https://elib.gsmu.by/handle/GomSMU/3946 (In Russ.).

2. Alekperov RT. Mixed connective tissue disease, undifferentiated connective tissue disease and overlap syndromes. Almanac of Clinical Medicine. 2019;47(5):435-444. (In Russ.). URL: https://cyberleninka.ru/article/n/smeshannoe-zabolevanie-soedinitelnoy-tkani-nedifferentsirovannoe-zabolevanie-soedinitelnoy-tkani-i-perekrestnye-sindromy

3. Bashkueva EV, Batudaeva TI. Overlap syndrome in clinical rheumatological practice. Bulletin of BSU. Medicine and pharmacy. 2018;(1):17-26. [date of access 2024 January 07]. Available from: https://cyberleninka.ru/article/n/overlap-sindrom-v-klinicheskoy-revmatologicheskoy-praktike (In Russ.).

4. Shayakhmetova RU, Ananyeva LP. Mixed connective tissue disease. Modern Rheumatology Journal. 2019;13(1):11-18. (In Russ.). doi: 10.14412/1996-7012-2019-1-11-18

5. Makarova TP, Vakhitov KhM, Sabirova DR, Sadykova DI, Khusnutdinova LR, Firsova NN, et al. Evolution of Mixed Connective Tissue Disease in 7 Years Old Child: Clinical Case. Current Pediatrics. 2020;19(3):214-219. (In Russ.). doi: 10.15690/vsp.v19i3.2117

6. Verkhotin AA, Saikovsky RS, Lesnyak VN. Clinical case of mixed connective tissue disease. Clinical practice. 2012;9(1):46-52. [date of access 2024 January 07]. Available from: https://cyberleninka.ru/article/n/klinicheskiy-sluchay-smeshannogo-zabolevaniya-soedinitelnoy-tkani (In Russ.).

7. Akhmedov VA, Kuzovkin AN, Zablotskaya AA, Sezina IA, Chupina AA. A rare clinical case of mixed connective tissue disease in a middle-aged patient. Siberian Medical Journal. 2015;(1):111-113. [date of access 2024 January 07]. Available from: https://cyberleninka.ru/article/n/redkiy-klinicheskiy-sluchay-smeshannogo-zabolevaniya-soedinitelnoy-tkani-u-patsientki-srednego-vozrasta

8. Mukvich EN, Belskaya EA, Petrenko LB, Lyudvik TA. Mixed connective tissue disease in the practice of a pediatric cardiorheumatologist. Child’s health. 2015;65(5):119-124. [date of access 2024 January 07]. Available from: https://cyberleninka.ru/article/n/smeshannoe-zabolevanie-soedinitelnoy-tkani-v-praktike-detskogo-kardiorevmatologa

9. Didier K, Bolko L, Giusti D, Toquet S, Robbins A, Antonicelli F, et al. Autoantibodies Associated with Connective Tissue Diseases: What Meaning for Clinicians? Front Immunol. 2018;9:541. doi: 10.3389/fimmu.2018.00541

10. Sapkota B, Al Khalili Y. Mixed Connective Tissue Disease. [Updated 2023 Apr 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. [date of access 2024 January 07]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542198/

11. John KJ, Sadiq M, George T, Gunasekaran K, Francis N, Rajadurai E, et al. Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria. Int J Rheumatol. 2020;2020:9692030. doi: 10.1155/2020/9692030

12. Tanaka Y, Kuwana M, Fujii T, Kameda H, Muro Y, Fujio K, et al. 2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases. Mod Rheumatol. 2021;31(1):29-33. doi: 10.1080/14397595.2019.1709944


Review

For citations:


Spoda N.N., Nikiforova O.L., Gorbach D.S., Lin N.V. Clinical observation of a patient with mixed connective tissue disease in an outpatient practice. Health and Ecology Issues. 2024;21(1):129-137. (In Russ.) https://doi.org/10.51523/2708-6011.2024-21-1-16

Views: 210


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)