Assessment of the risk factors of glycemic variability in patients with diabetes mellitus type 2

Abstract

Objective: to assess the presence of glycemic variability in patients with diabetes mellitus type 2 (DM Type 2), as well as to identify the risk factors which affect the degree of expression of the variability indices. Material and methods. Glycemic variability indices were assessed in 92 patients with DM Type 2 receiving different hypoglycemic therapy regimens. Results . It has been found that glycemic variability in 78 % of the examined patients with DM Type 2 was expressed and depended on the regimen of hypoglycemic therapy. The use of insulin therapy in the treatment regimen in patients with DM Type 2 and a BMI of less than 28.6 kg/m² is a risk factor that increases glycemic variability. Postprandial hyperglycemia (2 hours after breakfast) is caused by high variability regardless of the regimen of hypoglycemic therapy. SD variability indices and glycemic amplitude are the assessment criteria for the degree of glycemic variability in the postprandial period of time. Conclusion . Glycemic variability in patients with DM Type 2 is expressed and depends on the regimen of hypoglycemic therapy. Calculation of glycemic variability indices in glycemic self-control will improve individual target glycemia values and it will make it possible to correct the tactical scheme of hypoglycemic therapy on an outpatient basis.