Features of lipid metabolism in multiple organ dysfunction syndrome: causes and consequences of the resulting metabolic changes
https://doi.org/10.51523/2708-6011.2024-21-3-01
Abstract
The review presents data from various researchers, including the authors of this article, regarding the role of lipid metabolism disorders, as well as the causes that caused them in the formation of multiple organ dysfunction syndrome (MODS). Information is provided on the contribution of intense lipolysis in fat depots to the development of the immune response, as well as the formation of acute respiratory distress syndrome and acute kidney injury. The contribution of intense lipolysis to the process of changing the composition of fatty acids in blood plasma is characterized. The importance of intensifying the oxidative metabolism of arachidonic acid in the blood in the development of circulatory disorders and the occurrence of systemic inflammation is shown. Changes in lipid metabolism of erythrocyte membranes and its effect on hemodynamics are described. The relevance between disorders of lipid metabolism, dysfunction of cell membranes and their consequences, including the development of necrotic processes in tissues, has been characterized. Particular attention is paid to the importance of reducing the content of total cholesterol, as well as high-, low- and very low-density lipoprotein cholesterol in the formation of MODS, in particular, the proposed ways of influencing cholesterol deficiency on the progression of organ dysfunction are described. Data are provided on changes in the content of modified lipoproteins, as well as phospholipids and triglycerides in the blood plasma during MODS. The presence and probable role of plasma plasmalogen deficiency in organ disorders in MODS is noted. The problem of functional and metabolic role of peroxisome and mitochondria dysfunction in the pathogenesis of MODS is considered. The rationale for the importance of monitoring lipid metabolism parameters when assessing the severity of the condition of patients with MODS is provided.
About the Authors
A. N. Osipenko
Mogilev State A. Kuleshov University
Belarus
Belarus
Alexander N. Osipenko, Senior Lecturer, Department of Natural Sciences,
Mogilev
S. A. Tachyla
Mogilev Regional Clinical Hospital;
Vitebsk State Order of Peoples’ Friendship Medical University
Belarus
Belarus
Siarhei A. Tachyla, Candidate of Medical Sciences, Associate Professor, Anesthesiologist-Reanimatologist at the Department of Anesthesiology and Intensive Care;
Head of the branch of Departments of Anesthesiology and Intensive Care with the course of Advanced Training and Retraining and the Department of Hospital Surgery with the course of Advanced Training and Retraining,
Vitebsk
A. V. Marochkov
Mogilev Regional Clinical Hospital;
Vitebsk State Order of Peoples’ Friendship Medical University
Belarus
Belarus
Alexey V. Marochkov, Doctor of Medical Sciences, Professor, Anesthesiologist-Reanimatologist at the Department of
Anesthesiology and Intensive Care;
Professor of the branch of Departments of Anesthesiology and Intensive Care with the course of Advanced Training
and Retraining and the Department of Hospital Surgery with the course of Advanced Training and Retraining,
Vitebsk
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Review
For citations:
Osipenko A.N., Tachyla S.A., Marochkov A.V. Features of lipid metabolism in multiple organ dysfunction syndrome: causes and consequences of the resulting metabolic changes. Health and Ecology Issues. 2024;21(3):7-16. (In Russ.) https://doi.org/10.51523/2708-6011.2024-21-3-01
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