Wound healing after the implantation of the cartilage autograft and allograft (an experimental study)
https://doi.org/10.51523/2708-6011.2022-19-4-13
Abstract
Objective. To compare the wound healing after implantation of the freshly frozen allogeneic cartilage and the autogenic cartilage in a cutaneous flap.
Materials and methods. Two groups of eighteen non-breed white lab rats weighing 180-200 g of both genders were studied. Each specimen had a plastic material with the inclusion of a skin flap and cartilage graft formed. Group 1 used the animal’s own cartilage, group 2 used freshly frozen allogenic cartilage. Histological examination of the flap and graft preparations was carried out on the 7th, 14th and 21st days after the intervention.
Results. Semi-quantitative evaluation of inflammation and tissue reaction after cartilage autograft and allograft implantation was carried out. A gradual decrease in the evidence of the inflammatory reaction and the formation of a fibrous capsule around the implant during the study period was registered. The comparative analysis revealed no statistically significant differences in each of the indicators.
Conclusion. Implantation of an allograft from freshly frozen cartilage has no negative effect on skin flap wound healing in the experiment. Freshly frozen allogenic cartilage can be used for reconstructive interventions on a par with autologous material.
About the Authors
S. A. Ivanou
Gomel State Medical University
Belarus
Belarus
Siarhei A. Ivanou, Candidate of Medical Sciences, Associate Professor at the Department of Oncology
Gomel
D. A. Zinovkin
Gomel State Medical University
Belarus
Belarus
Dmitry A. Zinovkin, Candidate of Biological Sciences,
Associate Professor at the Department of Pathology
Gomel
O. G. Khorov
Grodno State Medical University
Belarus
Belarus
Oleg G. Khorov, Doctor of Medical Sciences, Professor,
Head of the Department of Otorhinolaryngology
Grodno
V. V. Pohozhay
Gomel State Medical University
Belarus
Belarus
Vladimir V. Pohozhay, Candidate of Medical Sciences,
Associate Professor at the Department of Oncology
Gomel
V. S. Ivanou
Gomel State Medical University
Belarus
Belarus
Victar S. Ivanou, Student of 5th year
Gomel
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Review
For citations:
Ivanou S.A., Zinovkin D.A., Khorov O.G., Pohozhay V.V., Ivanou V.S. Wound healing after the implantation of the cartilage autograft and allograft (an experimental study). Health and Ecology Issues. 2022;19(4):95-102. (In Russ.) https://doi.org/10.51523/2708-6011.2022-19-4-13
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