ABNORMAL FOLIC ACID HOMOCYSTEINE METABOLISM AS MATERNAL RISK FACTORS FOR DOWN SYNDROME IN JAPAN
https://doi.org/10.51523/2708-6011.2004-1-1-7
Abstract
Department of Public Health, Department of Pediatrics, Department of Molecular Epidemiology, Biostatistics Section and Department of Molecular Medicine,Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Background: Japan has been considered as «a folate sufficient area», since traditional Japanese food contains an adequate amount of folic acid. However, the recent westernized food style of young Japanese mothers may affect the intake of folic acid among them. This food style may contribute to the occurrence of Down syndrome, which has proved to be linked to abnormal folate and homocysteine metabolisms. Aim of the study: To preliminary evaluate the levels of folic acid, homocysteine and other relevant factors which are associated with folate metabolism, among Japanese women who had pregnancies affected by Down syndrome. Methods: Blood samples from 31 women who had pregnancies affected by Down syndrome (DS) were obtained. 60 age-matched control blood samples were also obtained from mothers who had not experienced miscarriages or abnormal pregnancies
About the Authors
NOBORU TAKAMURAJapan
TATSURO KONDOH
Japan
SYOHEI OHGI
Japan
KOKICHI ARISAWA
Japan
MARIKO MINE
Japan
SHUNICHI YAMASHITA
Japan
KIYOSHI AOYAGI
Japan
References
1. Smith G, Berg J (1976). Down's anomaly. 2d ed. Churchill Livingstone, Edinburgh and New York.
2. Penrose L.S (1933). The relative effects of paternal and maternal agin mongoli. J. Genet 27: e sm 219.
3. Hook E.G (1982). Epidemiology of Down syndrome. In: Pueschel S.M; Rynders J.E (ed) Down Syndrome. Advances in Biomedicine and the Behavioral Scieces. Ware Press, Cambridge.
4. Hook E.B, Cross P.K, Schreinemachers D.M. (1983). Chromosomal abnormality rates at amniocentesis and in live-born infants. JAMA 249: 2034—2038.
5. James S.J., Pogribna M., Pogribny I.P., Melnyk S., Hine R.J., Gibson J.B., Yi P., Tafoya D.L., Swenson D.H., Wilson V.L., Gaylor D.W. (1999). Abnormal folatemetabolism and muttion in the a
6. methylenetetrahdrofolate reductase gene my be y a
7. maternal risk factors for Down syndrome. lin Am J C
8. Nutr 70:495—501.
9. Botto L.D., Yang Q. (2000). 5, 10- Methylenetetrahydrouctase gene folate red variants and congenital anomalE review. Am J ies: a HuG Epidemiol. 151: 862—77.
10. The National Nutrition Survey in Japan (2001) Ministry of Health, Labour and Welfare, Japan, pp 1—244 (Japanese).
11. Couch S.C., Cross A.T., Kida K., Ros E., Plaza I., Shea S., Deckelbaum R. (2000). Rapid westernization of children's blood cholesterol in 3 countries: evidence for nutrient-gene interactions? Am J Clin Nutr. 72: 12668—12748.
12. Honein M.A. Paulozzi L.J., Mathews T.J., Erickson J.D., Wong L.Y. (2001). Impact of folic acid fortif he up ication of t US food sply on the occurrence of neural tube defects. JA81—6.
Review
For citations:
TAKAMURA N., KONDOH T., OHGI S., ARISAWA K., MINE M., YAMASHITA Sh., AOYAGI K. ABNORMAL FOLIC ACID HOMOCYSTEINE METABOLISM AS MATERNAL RISK FACTORS FOR DOWN SYNDROME IN JAPAN. Health and Ecology Issues. 2004;(1):41-44. (In Russ.) https://doi.org/10.51523/2708-6011.2004-1-1-7
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