DUAL ROLE OF PEROXYNITRITE IN ORGANISM
https://doi.org/10.51523/2708-6011.2004-1-1-6
Abstract
Peroxynitrite (ONOO" and HOONO) is an important intermediate in processes with simultaneous generation O2- and NO. Peroxynitrite ability to efficiently modify molecule structure is due to free radical formation (OH, CO3-, NO2) in its reactions. In an organism the peroxynitrite plays a dual role: positive (the participation in cellular immunity processes, and in the regulation of the activity of cell signal transduction enzymes) and negative (the participation in the development of cell and tissue oxidative stress). Cytotoxic and cytoprotective effects of peroxynitrite are considered on the models of myocardial ischaemia" reperfusion.
References
1. Болдырев А.А. Окислительный мозг и стресс // Соросовский образовательный журнал. - 2001. - Т. 7, № 4. - С. 21-28
2. Маеда Х., Акаике Т. Оксид азота и кислородные радикалы при инфекции, воспалении и раке // «Биохимия». - 1998. - Т. 63, № 7. - С. 1007-1019.
3. Недоспасов А.А. Биогенный NO в конкурентных отношениях // «Биохимия». - 1998. - Т. 63, № 7. - С. 881-904.
4. Реутов В.П., Сорокина Е.Г., Охотин В.Е., Косицин И. С. Циклические превращения оксида азота в организме млекопитающих - М., «Наука», 1997. - 156 с.
5. Стародубцева М.Н., Черенкевич С.Н. Роль гемоглобина в окислительном стрессе эритроцитов, вызванном пероксиазотистой кислотой / Пурины и монооксид азота: регуляторная функция в организме. Сб. статей / Под ред. В.Н. Гурина, В.А. Кульчицкого, А.Г. Чумака - Мн., УП «Технопринт», 2003. - С. 136-141.
6. СтародубцеваМ.Н., Черенкевич С.Н. Механизмы реакций гемоглобина с пероксинитритом в растворе // Весщ НАН Беларуа (News of Biomedical Sciences), - 2003, № 2, C. 86-90.
7. Стокле Ж.К., Мюлле Б., Андрианцитохайна Р., Клещев А. Гиперпродукция оксида азота в патофизиологии кровеносных сосудов // «Биохимия». - 1998. - Т. 63, № 7. - С. 976-983.
8. Cassina A., Radi R. Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport // Arch. Biochem. Biophys. - 1996. - Vol. 328, № 2. - P. 309-316.
9. Castro L., RodriguezM., Radi R. Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide // J. Biol. Chem. - 1994. - Vol. 269, № 47. - P. 29409-29415.
10. Cheung P.Y., Wang W., Schulz R. Glutatione protects against myocardial ischaemia-reperfussion injury by detoxifying peroxynitrite // J. Mol. Cell. Cardiol. - 2000. - Vol. 32. - P. 1669-1678.
11. Cooke Ch. LM., Davidge S. T. Peroxynitrite increases iNOS through NF-kB and decreases prostacyclin synthase in endothelial cells // Am. J. Physiol. Cell. Physiol. - 2002. - Vol. 282. - P. C. 395-402.
12. CrossA.H., ManningP.T., KeelingRM., Schmidt R.E. Peroxynitrite formation within the central nervous system in active multiple sclerosis // J. Neuroimmunol. - 1998. - Vol. 88, № 1-2. - P. 45-56.
13. Droge W. Free radicals in the physiological control of cell function // Physiol. Rev. - 2002. - Vol.
14. - P. 47-95.
15. Ferdinandy P., SchulzR. Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfussion injury and preconditioning // British J. Pham. - 2003. - Vol. 138. - P. 532-543.
16. Ferdinandy P, DanialH., Ambrus I., Bothery R.A., Schulz R. Peroxynitrite is a major contributor to cytokine-induced myocardial failure // Circ. Res. - 2000. - Vol. 87. - P. 241-247.
17. Freeman B.A., Gutierrez H., Rubbo H. Nitric oxide: a central regulatory species in pulmonary oxidant reactions // Am. J. Physiol. - 1995. - Vol. 268, № 5, pt.
18. - P. L697-L698.
19. Grzelak A., Soszynski M., Bartosz G. Inactivation of antioxidant enzymes by peroxynitrite // Scand. J. Clin. Lab. Invest. - 2000. - Vol. 60. - P. 253-258.
20. Ischiropoulos H., Al-Mehdi A.B. Peroxynitrite-mediated oxidative protein modifications // FEBS Letters. - 1995. - Vol. 364, № 3. - P. 279-282.
21. Ischiropoulos H., Zhu L., Beckman J.S. Peroxynitrite formation from macrophage-derived nitrite oxide // Arch. Biochem. Biophys. - 1992. - Vol. 298, № 2. - P. 446- 451.
22. Kosaka H. Nitric oxide and hemoglobin interactions in the vasculature // Biochim. Biophys. Acta. - 1999. - Vol. 1411. - P. 370-377.
23. Kooy N.W., Lewis S.J., Royall J.A., Ye Y.Z., Kelly D.R., Beckman J.A. Extensive tyrosine nitration in human myocardial inflammation and evidence for the presence of peroxynitrite // Crit. Care Med. - 1997. - Vol. 25. - P. 812-819.
24. Li Ch., Jackson R.M. Reactive species mechanisms of cellular hypoxia-reoxygenation injury // Am. J. Physiol. Cell. Physiol. - 2002. - Vol. 282. - P. C227-C241.
25. Mallozzi C., Di Stasi A.M. Peroxynitrite activates kinases of the SRC family and upregulates tyrosine phosphorylation signaling // Free Rad. Biol. Med. - 2002. - Vol. 33, № 6. - P. 744- 754.
26. Mallozzi C., Di Stasi A.M., Minetti M. Peroxynitrite modulates tyrosin-dependent signal transduction pathway of human erythrocyte band 3 / FASEB J. - 1997. - Vol. 11, № 14. - P. 1281- 1290.
27. Minetti M., Scorza G., Pietraforte D. Peroxynitrite induced long-lived tyrosyl radical(s) in oxyhemoglobin of red blood cells through a reaction involving CO2 and a ferryl species. // Biochemistry. - 1999. - Vol. 38. - P. 2078-2087.
28. Nossuli T. O., Hayward R., Jensen D., Scalia R., Lefer A. M. Mechanisms of cardioprotection by peroxynitrite in myocardial ischaemia and reperfussion injury // Am. J. Physiol. - 1998. - Vol. 275. - P. H509-H519.
29. Okamoto T., Akaike T., Nagano T. Activation of human neutrophil procollagenase by nitrogen dioxide and peroxynitrite: a novel mechanism for procollogenase activation involving nitric oxide // Arch. Biochem. Biophys. - 1997. - Vol. 342, № 2. - P. 261-274.
30. Padmaja S., Squadrito G.L., Pryor W.A. Inactivation of glutathione peroxidase by peroxynitrite // Arch. Biochem. Biophys. - 1998. - Vol. 349, № 1. - P. 1-6.
31. PackerM.A., MurphyM.P. Peroxynitrite formed by simultaneous nitric oxide and superoxide generation causes cycloporin-A-sensitive mitochondrial calcium efflux and depolarization // Eur. J. Biochem. - 1995. - Vol. 234. - P. 231-239.
32. Pryor W.A., Squadrito G.L. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide // Am. J. Physiol. - 1995. - Vol. 268, № 5 (pt. 1), P. 699-722.
33. Radi R., Peluffo G., Alvarez M.N., Naviliat M., Cayota A. Unraveling peroxynitrite formation in biological systems // Free Rad. Biol. Med. - 2001. - Vol. 30, № 5. - P. 463-488.
34. Szabo C., Mabley J.G., Moeller S.M., Shimanovich R., Pacher P., Virag L., Soriano F.G., Van Duzer J.H., Williams W., Salzman A.L., Groves J.T. Part 1: Pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potential peroxynitrite decomposition catalyst // Molecular Medicine. - 2002. - Vol. 8 (10). - P. 571-580.
35. Torreilles F., Sulman-Tabcheh S., Guerin M., Torreilles J. Neurodegenerative disorders: the role of peroxynitrite // Brain Res. Rev. - 1999. - Vol. 2. - P. 153-163.
36. Vinten-Johansen J. Physiological effects of peroxynitrite: potential products of the environment // Circ. Res. - 2000. - Vol. 87. - P. 170-172.
37. Yasmin W., Strynadka K.D., SchulzR. Generation of peroxynitrite contributes to ichaemia-reperfussion injury in isolated rat hearts // Cardiovasc. - 1997. - Vol. 33. - P. 422-432.
Review
For citations:
Стародубцева М.Н. DUAL ROLE OF PEROXYNITRITE IN ORGANISM. Health and Ecology Issues. 2004;(1):35-41. (In Russ.) https://doi.org/10.51523/2708-6011.2004-1-1-6
Views: 490
Email this article 