Integrative parameter of platelet aggregation in intensive care of COVID-19 patients
https://doi.org/10.51523/2708-6011.2021-18-4-13
Abstract
Objective. To conduct a comparative analysis of changes in platelet aggregation parameters in COVID-19 patients which are related to anticoagulant therapy and to determine the effectiveness of the integrative parameter of platelet aggregation.
Materials and methods. 34 patients with confirmed COVID-19 (group 1) were included into the study. To compare the obtained results, healthy females were included into group 2 (n = 30). The following parameters of aggregation were determined: degree, time, rate and area of aggregation (until its maximum degree).
Results. The area of aggregation is the best among all the parameters of platelet aggregation to diagnose COVID-19 in patients according to the Hosmer-Lemeshow test: with an ADP inducer — 0.3 μg/ml (Chi-square = 9.481, p = 0.303); ADP — 1.25 μg/ml (Chi square = 12.577, p = 0.127); ADP — 2.5 μg/ml (Chi-square = 6.226, p = 0.622); adrenaline — 2.5 μM (Chi-square = 7.367, p = 0.498); adrenaline — 5 μM (Chi-square = 6.824, p = 0.556).
Conclusion. The area of aggregation is an informative integrative parameter that allows to quantify the degree of aggregation in the treatment of hypercoagulation syndrome in COVID-19 patients.
About the Authors
A. V. Marochkov
Mogilev Regional Clinical Hospital
Belarus
Belarus
Aliaksei V. Marochkov, DMedSc, Professor, anesthesiologist-resuscitator at the Anesthesiology and Resuscitation Department
Mogilev
A. L. Lipnitski
Mogilev Regional Clinical Hospital
Belarus
Belarus
Artur L. Lipnitski, PhD (Med), anesthesiologist-resuscitator, Head of the Department for the Coordination of Activities for the Collection of Donor Organs and Tissues for Transplantation
Mogilev
A. G. Starovoitov
Mogilev Regional Blood Transfusion Station
Belarus
Belarus
Aliaksandr G. Starovoitov, valeologist
Mogilev
V. U. Dazortsava
Mogilev Regional Clinical Hospital
Belarus
Belarus
Volha U. Dazortsava, laboratory physician at the Centralized Laboratory of Clinical Biochemistry
Mogilev
V. A. Livinskaya
Belarusian-Russian University
Belarus
Belarus
Viktoryia A. Livinskaya, PhD (Physics and Mathematics), Associate Professor at the Department of Finance and Accounting
Mogilev
References
1. Escher R, Breakey N, Lämmle B. Severe COVID-19 infection associated with endothelial activation. Thromb Res. 2020; Jun;190:62. DOI: https://doi.org/10.1016/j.thromres.2020.04.014
2. Iba T, Levy JH, Connors JM, et al. The unique characteristics of COVID-19 coagulopathy. Crit Care. 2020;24(1):360. DOI: https://doi.org/10.1186/s13054-020-03077-0
3. Panigada M, Bottino N, Tagliabue P, et al. Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis. J Thromb Haemost. 2020; 18(7):1738-1742. DOI: https://doi.org/10.1111/jth.14850
4. COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19). [Electronic resource]. Treatment Guidelines. National Institutes of Health; 2020. [date of access 2020 February 10]. Available from: https://www.covid19treatmentguidelines.nih.gov
5. Carsana L, Sonzogni A, Nasr A, et al. Pulmonary post-mortem findings in a large series of COVID-19 cases from northern Italy. Published online 2020 Apr 22. DOI: https://doi.org/10.1101/2020.04.19.20054262
6. Interim guidelines for the prevention, diagnosis and treatment of novel coronavirus infection (COVID-19). Version 10 (02/08/2021).[Electronic resource]. Ministry of Health of the Russian Federation. [date of access 2020 Apr 12]. Available from: https://static-0.rosminzdrav.ru/system/attachments/attaches/000/054/588/original/%D0%92%D1%80%D0%B5%D0%BC%D0%B5%D0%BD%D0%BD%D1%8B%D0%B5_%D0%9C%D0%A0_COVID-19_%28v.10%29-08.02.2021_%281%29.pdf (In Russ.).
7. Yang X, Yang Q, Wang Y, et al. Thrombocytopenia and its association with mortality in patients with COVID-19. J Thromb Haemost. 2020;18(6):1469-1472. DOI: https://doi.org/10.1111/jth.14848
8. Levin GY, Popovicheva AN, Sosnina LN, Sheremetyev YuA. Aggregation and size of platelets in children with burn disease. Russian journal of hematology and transfusiology. 2019;64(4):462-470. (In Rus.). DOI: https://doi.org//10.35754/0234-5730-2019-64-4-462-470
9. Zubovskaya ET, Yurkevich TYu, Mitroshenko IV, Demidova RN. Platelet Aggregatometry in Clinical Practice: A Guide for Physicians. Minsk, Belarus: PronyaPlus. 2018. 67 p. (In Rus.).
10. Marochkov АV, Lipnitski AL, Tsopau DS, et al. Features of Platelet Aggregation in Patients with COVID-19 Infection. Preliminary results. Novosti Khirurgii. 2020;28 (5):558-564. (In Rus.). DOI: https://doi.org//10.18484/2305-0047.2020.5.558
11. Iba T, Levy JH, Levi M, Thachil J. Coagulopathy in COVID-19. J Thromb Haemost. 2020;18:2103-2109. DOI: https://doi.org/10.1111/jth.14975
12. Marini JJ, Gattinoni L. Management of COVID-19 respiratory distress. JAMA. 2020;323(22):2329-2330. DOI: https://doi.org/10.1001/jama.2020.6825
Review
For citations:
Marochkov A.V., Lipnitski A.L., Starovoitov A.G., Dazortsava V.U., Livinskaya V.A. Integrative parameter of platelet aggregation in intensive care of COVID-19 patients. Health and Ecology Issues. 2021;18(4):99-107. (In Russ.) https://doi.org/10.51523/2708-6011.2021-18-4-13
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