THE IMMUNOHISTOCHEMICAL ASSESSMENT OF THE CHARACTER OF LYMPHOID INFILTRATION IN VARIOUS FORMS OF THYROID PATHOLOGY
https://doi.org/10.51523/2708-6011.2017-14-4-5
Abstract
Objective: to characterize the phenotype of lymphocytes in lymphoid infiltrates in various forms of thyroid pathology. Material and methods . The operating material of 112 cases of thyroid diseases has been studied. The immunohistochemical examination using monoclonal antibodies to the antigens CD3, CD4, CD1α, CD23, CD25, CD8 and TGF-β has been conducted. Results. The quantitative assessment of lymphocyte subpopulations in lymphoid infiltrates in the tissue of the thyroid gland in thyrotoxic goiter, autoimmune thyroiditis, nodular euthyroid goiter, and thyroid cancer has been given.
About the Authors
K. M. Butolina
Grodno State Medical University
Belarus
Belarus
S. A. Lyalikov
Grodno State Medical University
Belarus
Belarus
V. A. Basinsky
Grodno State Medical University
Belarus
Belarus
T. T. Shtabinskaya
Grodno State Medical University
Belarus
Belarus
V. S. Aleksinsky
Grodno State Medical University
Belarus
Belarus
A. . Marshalek
Nicolaus Copernicus University
Belarus
Belarus
References
1. Министерство здравоохранения Республики Беларусь [Электронный ресурс] / Новости (пресс-релизы).- Минск, 2016.- Режим доступа: http://minzdrav.gov.by/ru/news?id=1314. - Дата доступа: 15.08.2016.
2. Алгоритмы диагностики и лечения злокачественных новообразований:сб. науч. ст. / РНПЦ онкологии и медицинской радиологии им. Н.Н. Александрова: О.Г. Суконко, С.А. Красный (отв. ред.) [идр.]. -Минск, 2012. - 508 с.
3. Hashimoto’s Thyroiditis Following Graves’ Disease / H. Umar [et al.] // Acta Med Indones. - 2010. - № 42 (1). -Р.31-35.
4. The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells / S.M. McLachlan [et al.] // Endocrinology. - 2007. -Vol. 148 (12). -Р. 5724-5733.
5. Джикаев, Г.Д. Особенности лимфоцитарной инфильтрации щитовидной железы при очаговом и аутоиммунном тиреоидите / Г.Д. Джикаев // Фундаментальные исследования. - 2014. - №10. - С.498-500.
6. Сравнительное изучение тиреоидита Хашимото и «очагового тиреоидита» / М.А. Пальцев [и др.] //Архив патологии. - 1999. - №5. - С. 46-51.
7. Иванова, О.И. Особенности морфологии щитовидной железы при хроническом аутоиммунном тиреоидите / О.И. Иванова, С.В. Логвинов, Т.В. Соломатина // Сибирский онкологический журнал. - 2006. - №2. - С. 71-75.
8. Thyroid cancer and inflammation / V. Guarino [et al.] // Mol Cell Endocrinol. - 2010. - Vol. 28,№ 321 (1). -Р.94-102.
9. Does chronic lymphocytic thyroiditis influence the staging of differentiated thyroid carcinoma? / M.A. Nemetz [et al.] // Braz J Otorhinolaryngol. - 2011. - Vol. 77(1). - Р. 77-83.
10. Infiltration of a mixture of immune cells may be related to good prognosis in patients with differentiated thyroid carcinoma / L. L. Cunha [et al.] // Clin Endocrinol (Oxf). - 2012. - Vol.77(6). -Р. 918-925.
11. Filipović, A. Influence of lymphocitic thyroiditis on prognostic outcome differentiated thyroid carcinoma / A. Filipović, I. Paunović, Lj Vucković // Acta Chir Iugosl. - 2010. - № 57 (2). -Р.85-94.
12. Well-differentiated thyroid carcinoma with concomitant Hashimoto's thyroiditis present with less aggressive clinical stage and low recurrence / B.Y. Huang [et al.] // Endocr Pathol. - 2011. - № 22 (3). - Р. 144-149.
Review
For citations:
Butolina K.M., Lyalikov S.A., Basinsky V.A., Shtabinskaya T.T., Aleksinsky V.S., Marshalek A. THE IMMUNOHISTOCHEMICAL ASSESSMENT OF THE CHARACTER OF LYMPHOID INFILTRATION IN VARIOUS FORMS OF THYROID PATHOLOGY. Health and Ecology Issues. 2017;(4):27-31. (In Russ.) https://doi.org/10.51523/2708-6011.2017-14-4-5
Views: 315
Email this article 