THE LEVELS OF SOME CHEMOKINES IN THE BLOOD SERUM OF PATIENTS WITH EXACERBATION OF CHRONIC PURULENT RHINOSINUSITIS

Abstract

Aim: to study the levels of fractalkine and IL-8 in blood serum of patients with exacerbation of chronic purulent rhinosinusitis. Material and methods . Twenty patients suffering from chronic purulent rhinosinusitis were examined during the stage of exacerbation. The control group consisted of twenty conditionally healthy individuals with nasal septum deviation. The blood sampling of the examined patients was performed. The levels of fractalkine and IL-8 in the blood serum were determined by ELISA. Results. The exacerbation of purulent chronic rhinosinusitis leads to increased levels of both fractalkine and IL-8 in the blood serum of patients, which contributes to the involvement of neutrophils, monocytes, and cytotoxic T-lymphocytes into the inflammatory process. Chemokines IL-8 and fractalkine play an important role in the pathogenesis of chronic purulent rhinosinusitis, which suggests the reasonability of application of pharmacological preparations that block their functions. Conclusions. The carried out study revealed increased levels of both fractalkine and IL-8 in the blood serum of the patients with chronic purulent rhinosinusitis at the stage of exacerbation