HE ANALYSIS OF INTERRELATION OF THE FILTRATIONAL ABILITY OF KIDNEYS AND THE INDICATORS OF THE ANDROGENIC STATЕ IN PATIENTS WITH DIABETES MELLITUS TYPE 1
https://doi.org/10.51523/2708-6011.2017-14-2-5
Abstract
Objective: to analyze the interrelation between the duration of diabetes mellitus (DM), renal function, and the indicators of the androgenic state in patients with DM type 1. Material and methods. 173 males with DM 1 type at the age of 18-55 years were examined. The control group included 25 almost healthy males at the age of 21-41. The compensation of DM was estimated according to the level of glycosylated hemoglobin. Also, we assessed the indicators of lipid profile, GFR MDRD, total testosterone, luteinizing hormone/follicle-stimulating hormone (LH/FSH), prolactin, sex hormone-binding globulin. Results. The experience of diabetes mellitus was significantly higher in patients with GFR MDRD < 60 ml/min/1.73 m2. Patients with GFR MDRD < 60 ml/min/1.73 m2 in the absence of compensation (Hb A1c > 7.5 %) noted higher levels of LH, FSH, LH/FSH and significantly lower levels of general and free testosterone. Patients having GFR MDRD > 60ml/min/1.73 m2 revealed no significant distinctions between the levels of testosterone and gonadotrophins in various compensation of DМ. Conclusion. The revealed changes are important risk factors for the development and progression of vascular complications and demand that adequate measures should be taken.
About the Authors
N. . Vaschenko
Republican Research Centre for Radiation Medicine and Human Ecolog
Belarus
Belarus
T. V. Mokhort
Belarusian State Medical University
Belarus
Belarus
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Review
For citations:
Vaschenko N., Mokhort T.V. HE ANALYSIS OF INTERRELATION OF THE FILTRATIONAL ABILITY OF KIDNEYS AND THE INDICATORS OF THE ANDROGENIC STATЕ IN PATIENTS WITH DIABETES MELLITUS TYPE 1. Health and Ecology Issues. 2017;(2):20-26. (In Russ.) https://doi.org/10.51523/2708-6011.2017-14-2-5
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