THE MECHANISM OF ENDOTHELIAL DYSFUNCTION FORMATION IN YOUNG PATIENTS WITH SPONDYLOGENIC VERTEBROBASILAR INSUFFICIENCY
https://doi.org/10.51523/2708-6011.2016-13-4-6
Abstract
Objective: to determine the type of changes of shear stress in vessels of the vertebrobasilar system in patients of young age with spondylogenic vertebrobasilar insufficiency (SVI). Material and methods. We examined 131 patients (70 women and 61 men) aged 18-40 (average age was 29.8 ± 3.8) with manifestations of spondylogenic vertebrobasilar insufficiency associated with muscular reflex, neurovascular and radicular syndromes of osteochondrosis of the cervical part of the vertebral column. 25 healthy donors made the control group. All the patients underwent radiological examination of the cervical part of the vertebral column with functional probes, doppler and duplex ultrasound of vessels of the neck and arteries of the head with functional probes; we performed the detection of endothelin-1, nitric oxide (NO) of blood serum. The changes of the shear stress in vessels of the vertebrobasilar system were assessed analyzing the Stuart index (ISD), systolic and diastolic parameter. Results. It has been found that development of spondylogenic vertebrobasilar insufficiency is accompanied by signs of endothelial dysfunction (ED), which is characterized by increased concentration of endothelin-1 related to the reduction of active metabolite of nitrogen oxide - S-NO. One of the mechanisms of ED in this cohort of patients is changes of the shear stress. Conclusion. In order to predict the development of ED in patients with spondylogenic vertebrobasilar insufficiency, it is recommended to pay particular attention to the state of the vascular wall.
About the Authors
N. A. Nekrasova
Kharkiv National Medical University, Ukraine
Belarus
Belarus
E. L. Tovazhnyanskaya
Kharkiv National Medical University, Ukraine
Belarus
Belarus
N. V. Galinovskaya
Gomel State Medical University
Belarus
Belarus
A. N. Tsukanov
Republican Research Center for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
References
1. Волошин, П. В. Эндотелиальная дисфункция при цереброваскулярной патологии / П. В. Волошин, В. А. Малахов, А. Н. Завгородняя. - Харьков, 2006. - 92 с.
2. Волков, С.К. Вертебрально-базилярная недостаточность: клинические и диагностические аспекты / С. К. Волков // Неврология, нейропсихиатрия, психосоматика. - 2010. - № 2. - С. 33-39.
3. Калашников, В. И. Синдром позвоночной артерии / В. И. Калашников // Therapia. - 2007. - № 10. - С. 31-33.
4. Клиническая лабораторная диагностика. Национальное руководство / под ред. В. В. Долгова, В. В.Меньшикова. - М.: ГЭОТАР-Медиа, 2012. - Т. 1. - 928 с.
5. Мелкумянц, А. М. Механочувствительность артериального эндотелия / А. М. Мелкумянц, С. А. Балашов. - Тверь: Триада, 2005. - 208 с.
6. Мельхумянц, A. M. Регуляция просвета магистральных артерий в соответствии с напряжением сдвига на эндотелии / A. M. Мельхумянц, С. А. Балашов, B. M. Хаютин // Физиол. журн. Сеченова. - 1992. - Т. 78. - С. 70-78.
7. Ратнер, А. Ю. Шейный остеохондроз и церебральные нарушения / А. Ю. Ратнер. - Казань.: Изд-во Казанского университета, 1970. - 231 с.
8. Тян, В. Н. Современные подходы к лечению ранних форм сосудистой патологии мозга / В. Н. Тян // Рефлексология. - 2007. - № 1-2 (13-14). - С. 30-34.
9. Яковлев, Н. А. Вертебрально-базилярная недостаточность. Синдром вертебробазилярной артериальной системы / Н. А. Яковлев. - М., 2001. - 396 с.
10. Barakat, A. I. Dragging along: the glycocalyx and vascular endothelial cell mechanotransduction / A. I. Barakat // Circulation research. - 2008. - № 102. - P. 747-748.
11. Oxidative stress and endothelial dysfunction in cerebrovascular disease / S. Chrissobolis [et al.] // Front. Biosci. - 2011. - Vol. 16(1). - P. 1733-1745.
12. Forstermann, U. Nitric oxide and oxidative stress in vascular diseases / U. Forstermann // Pflugers Arch. - 2010. - Vol. 459(6). - P. 923-939.
13. Endothelial function and oxidative stress in cardiovascular diseases / Y. Higashi [et al.]. // Circ. J. - 2009. - Vol. 73(3). - P. 411-419.
14. Ngai, C. Y. Vascular Responses to Shear Stress: The Involvement of Mechanosensors in Endothelial Cells / C. Y. Ngai, X. Yao // Open Circ. Vasc. J. - 2010. - Vol. 3. - P. 85-94.
15. Papaioannou, T. G. Vascular wall shear stress: basic principles and methods / T. G. Papaioannou, C. Stefanadis // Hellenic J Cardiol. - 2005. - Vol. 46(1). - P. 9-15.
16. Urso, C. Oxidative stress and endothelial dysfunction / C. Urso, G. Caimi // Minerva Med. - 2011. - Vol. 102(1). - P. 59-77.
17. Vanhoutte, P. M. Endothelial dysfunction: the first step toward coronary arteriosclerosis / P. M. Vanhoutte // Circ. J - 2009. - Vol. 73(4). - P. 595-601.
Review
For citations:
Nekrasova N.A., Tovazhnyanskaya E.L., Galinovskaya N.V., Tsukanov A.N. THE MECHANISM OF ENDOTHELIAL DYSFUNCTION FORMATION IN YOUNG PATIENTS WITH SPONDYLOGENIC VERTEBROBASILAR INSUFFICIENCY. Health and Ecology Issues. 2016;(4):28-32. (In Russ.) https://doi.org/10.51523/2708-6011.2016-13-4-6
Views: 287
Email this article 