CLINICAL AND MORPHOLOGICAL ANALYSIS OF BRCA-1 IDENTICATION WITH IMMUNOHISTOCHEMICAL ASSESSMENT OF ANDROGEN RECEPTOR AND C-KIT (CD117) EXPRESSION IN TRIPLE-NEGATIVE BREAST CANCER IN WOMEN OF GRODNO REGION

We conducted the immunohistochemical examination of 2008 patients with breast cancer determining Her2/neu, receptor estrogene, and progesterone in Grodno region over 2010-2015. We revealed triple negative breast cancer to be negative to these markers in 19.8 %, with annual fluctuations of its share within 16.4-21.6 %. 39 women from the BRCA-1 database (449 women with breast cancer) detected triple negative breast cancer. Mutation of BRCA-1 was identified in 5 out of 39 (12.8 %) cases. Histologically, these tumors were presented by invasive ductal carcinoma, by G2-G3 and also medullary cancer in 3 cases, by G3 - in 2 cases. During the immunohistochemical study of 23 cases, CD-117 expression of varying intensity was detected in 11 (47.8 %) and focal nuclear expression of androgen receptors (< 1 %) in 1 case (4.35 %). The presence of C-kit (CD-117) hyperexpression presupposses the study of the possibility of the targeted therapy with imatinib by analogy with gastrointestinal stromal tumors, which, in turn, requires the inclusion of C-kit (CD 117) into the list of mandatory immunohistochemical markers in triple negative breast cancer, and the postoperative diagnosis of triple negative breast cancer presupposses the necessity for BRCA-1 mutation identification.

тройной негативный рак молочной железы, BRCA-1 мутации, экспрессия рецепторов андрогенов и C-kit, triple-negative breast cancer, BRCA-1 mutations, expression of androgen receptor and C-kit

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