ANALYSIS OF GENES IL-1Β (C511T), IL-2 (T330G), IL-13 (C1111T) POLYMORPHISM ASSOCIATION WITH THE DEVELOPMENT OF STOMACH DISEASES
https://doi.org/10.51523/2708-6011.2015-12-3-22
Abstract
Objective: to study the role of IL-1β (C511T), IL-2 (T330G), IL-13 (C1111T) gene polymorphism in the development of stomach diseases in Belarusian population. Material and methods. The study included 194 patients diagnosed with «chronic gastritis» and 68 patients diagnosedwith «cancer of the stomach». To determine polymorphisms of IL-2 (T330G), IL-13 (C-1111T) and IL-1β (C511T) genes, we used the method of allele-specific PCR (AS-PCR) and PCR detection of the length of restriction fragments (PCR-RFLP). Results . By the loci of IL-2 (T330G), IL-13 (C1111T), IL-1b (S511T) we revealed the correlation with oncopathology depending on the status of infection by various strains of H. pylori. Conclusion . The use of the revealed association of cytokine gene polymorphism with the development of the diseases makes it possible to select genetic components that determine the sensitivityof the population to the development of stomach diseases depending on H. pylori infection in Belarusian population.
About the Authors
A. V. Voropayeva
Republican Research Centre for Radiation Medicine and Human Ecology
Belarus
Belarus
O. V. Karpenko
Republican Research Centre for Radiation Medicine and Human Ecology
Belarus
Belarus
E. V. Bredikhina
Republican Research Centre for Radiation Medicine and Human Ecology
Belarus
Belarus
T. P. Krivun
Republican Research Centre for Radiation Medicine and Human Ecology
Belarus
Belarus
O. V. Osipkina
Gomel State Medical University
Belarus
Belarus
O. Yu. Baranov
Gomel State Medical University
Belarus
Belarus
References
1. Pathogenesis of Helicobacter pylori infection / J. G. Kusters [et al.] // Clin Microbiol Rev. - 2006. - Vol. 19, № 3. - P. 449-490.
2. IL-1 beta pro-inflammatory genotypes protect against gastro-oesophageal reflux disease through induction of corpus atrophy / T. Ando [et al.] // GUT. - 2006. - Vol. 55, № 2. - P. 158-164.
3. Effect of genetic polymorphism Inteleukin-1ß on gastritis, gastric juice pH, and recurrence of peptic ulcerdisease in Japanese subjects / T. Furuta [et al.] // Gastroenterology. - 2002. - Vol. 123, № 1. - P. 92-105.
4. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms / E. M. El-Omar [et al.] // Gastroenterology. - 2003. - Vol. 124. - P. 1193-1201.
5. Padol, I. Effect of Th1 cytokines on acid secretion in pharmacologically characterised mouse gastric glands / I. Padol, R. Hunt // Gut. - 2004. - Vol. 53. - P. 1075-1081.
6. Interleukin-2 Gene Polymorphisms Associated with Increased Risk of Gastric Atrophy from Helicobacter pylori Infection / Sh. Togawa [et al.] // Helicobacter. - 2005. - Vol. 10, № 3. - P. 172-178.
7. Cytokines, cytokine gene polymorphisms and Helicobacter pylori infection: Friend or foe? / C. Figueiredo [et al.] // World J Gastroenterol. - 2014. - Vol. 20, Is. 18. - P. 5235-5243.
8. Interleukin-1 β (IL-1 β) polymorphisms and gastric mucosal levels of IL-1β cytokine in Korean patients with gastric cancer // Y-W. Chang [et al.] // Int J Cancer. - 2005. - Vol. 114. - P. 465-471.
9. Helicobacter pylori seropositivityand cytokine gene polymorphisms / Y. Saijo [et al.] // World J.Gastroenterol. - 2007. - Vol. 13. - P. 4445-4451.
10. Genetic factors involved in the development of Helicobacter pylori-related gastric cancer / N. Hamajima [et al.] // Cancer Sci. - 2006. - Vol. 97. - P. 1129-1138.
Review
For citations:
Voropayeva A.V., Karpenko O.V., Bredikhina E.V., Krivun T.P., Osipkina O.V., Baranov O.Yu. ANALYSIS OF GENES IL-1Β (C511T), IL-2 (T330G), IL-13 (C1111T) POLYMORPHISM ASSOCIATION WITH THE DEVELOPMENT OF STOMACH DISEASES. Health and Ecology Issues. 2015;(3):97-102. (In Russ.) https://doi.org/10.51523/2708-6011.2015-12-3-22
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