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THE CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF ENDOMETRIOID ADENOCARCINOMA OF THE UTERINE CORPUS IN FEMALE PATIENTS WITH DIFFERENT DESEASE OUTCOMES

https://doi.org/10.51523/2708-6011.2015-12-3-10

Abstract

The article presents a retrospective comparison of the clinical and morphological criteria in 60 patients with endometrioid adenocarcinoma of the uterine corpus of I-III stages with good and poor outcomes. The increase of the stage according to FIGO is an independent prognostic feature of progression. MELF- pattern may be used as a pathomorphological predictor of tumor progression. The invasion of tumor of more than 54 % of the myometrium increases risks for relapse.

About the Authors

D. A. Zinovkin
epublican Research Center for Radiation Medicine and Human Ecology
Belarus


E. A. Nadyrov
epublican Research Center for Radiation Medicine and Human Ecology
Belarus


References

1. Клинические рекомендации. Онкология / под ред. В. И. Чиссова, С. Л. Дарьяловой. - М.: ГЭОТАР-Медиа, 2006. - С. 501-520.

2. Алгоритмы диагностики и лечения злокачественных новообразований / Гос. учреждение «Республ. научн.-практ. центр онкол. и мед. радиол. им Н. Н. Александрова»; редкол. О. Г. Суконко [и др.]. - Минск: Профессиональные издания, 2012. - С. 278-295.

3. Океанов, А. Е. Статистика онкологических заболеваний / А. Е. Океанов, П. И. Моисеев, Л. Ф. Левин; под ред. О. Г. Суконко. - Минск, 2014. - С. 147-152.

4. Damjanov, I. Cancer grading manual / I. Damjanov, F. Fan. - New York: Springer, 2013. - P. 121-122.

5. Necrosis related HIF-1α expression predicts prognosis in patients with endometrioid endometrial carcinoma / L. M. Seeber [et al.] // BMC Cancer. - 2010. - Vol. 307, № 10. - P. 1471-1477.

6. Endometrial сarcinoma / G. S. Silverberg [et al.] // World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of the Breast and Female Genital Organs / A. Fattaneh [et al.]. - Lyon, 2000. - P. 221-230.

7. Quantifying the risk of recurrence and death in stage III (FIGO 2009) endometrial cancer / S. A. Milgrom [et al.] // Gynecol. Oncol. - 2014. - Vol. 134, № 2. - P. 297-301.

8. Unusual epithelial and stromal changes in myoinvasive endometrioid adenocarcinoma: a study of their frequency, associated diagnostic problems, and prognostic significance / S. K. Murray [et al.] // Int. J. Gynecol. Pathol. - 2003. - Vol. 22, № 4. - P. 324-333.

9. Реброва, О. Ю. Статистический анализ медицинских данных. Применение прикладных программ Statistica / О. Ю. Реброва. - М.: МедиаСфера, 2002. - 512 c.

10. Trends in endometrial cancer incidence by race and histology with a correction for the prevalence of hysterectomy, SEER 1992 to 2008 / P. M. Jamison [et al.] // Cancer Epidemiol. Biomarkers Prev. - 2013. - Vol. 22, № 2. - P. 233-241.

11. Risk-scoring models for individualized prediction of overall survival in low-grade and high-grade endometrial cancer / M. M. Al Hilli [et al.] // Gynecol. Oncol. - 2014. - Vol. 133, № 3. - P. 485-493.

12. Lax, S. Prognostic parameters of endometrial carcinoma / S. Lax // Pathologe. - 2011. - Vol. 3, Suppl 2. - P. 255-264.

13. Unusual patterns of endometrial carcinoma including MELF and its relation to epithelial mesenchymal transition / R. J. Zaino [et al.] // Int. J. Gynecol. Pathol. - 2014. - Vol. 33, № 4. - P. 357-364.

14. Lymphovascular space invasion is an independent risk factor for nodal disease and poor outcomes in endometrioid endometrial cancer / S. R. Guntupalli [et al.] // Gynecol. Oncol. - 2012. - Vol. 124, № 1. - P. 31-35.

15. Does the presence of adenomyosis and lymphovascular space invasion affect lymph node status in patients with endometrioid adenocarcinoma of the endometrium? / F. Musa [et al.] // Am. J. Obstet. Gynecol. - 2012. - Vol. 207, № 5. - Р. 417-426.


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For citations:


Zinovkin D.A., Nadyrov E.A. THE CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF ENDOMETRIOID ADENOCARCINOMA OF THE UTERINE CORPUS IN FEMALE PATIENTS WITH DIFFERENT DESEASE OUTCOMES. Health and Ecology Issues. 2015;(3):46-50. (In Russ.) https://doi.org/10.51523/2708-6011.2015-12-3-10

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ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)