The Features of the Course and Outcomes of HIV Infection Diagnosed at the Stage of Pronounced Immunosuppression
https://doi.org/10.51523/2708-6011.2019-16-4-3
Abstract
Objective: to present the features of the course and outcomes of HIV infection diagnosed at the stage of pronounced immunosuppression.
Material and methods. Based on the primary CD4 + T-lymphocytes count, 492 patients living with HIV were divided into 2 groups: group 1 - 220 patients (CD4 + TL less than or equal to 350 cells/μl), group 2 - 272 patients (CD4 + TL more than 350 cells/µl). The statistical analysis was performed using the package «Statisticа» v.10.
Results. Among the patients of the first group there were more men than in the second group: 136 (61.8 %) and 125 (46 %), p < 0.001, respectively; more patients in HIV clinical stages 3 and 4 - 52.7 % and 27.6 %, p < 0.05; more ART patients: 208 (94.5 %) and 148 (54.4 %) p < 0.001, respectively. The levels of T-helpers and IRI (immunoregulatory index) in the patients of group 2 in the follow-up dynamics remained significantly higher compared with those of the patients of group 1. The incidence of tuberculosis was higher in group 1: 33 (15 %) and 15 (5.5 %), respectively, p < 0.05. In the first group, 23 (10.5 %) patients died, in the second - 9 (3.3 %), p < 0.003.
Conclusion. HIV-infection at the stage of pronounced immunosuppression was diagnosed in 220 patients - 44.7 % (95 % CI: 40.4-49.1) of the cases. Severe immunosuppression in the primarily diagnosed patients was associated with the presence of HIV clinical stages 3 and 4 (OR - 2.9; 95 % CI: 2.0-4.3), higher incidence rates of tuberculosis (OR - 3.02; 95 % CI: 1.6-5.7) and fatal outcomes (OR - 3.4; 95 % CI: 1.5-7.5), a slower increase in T-helpers and IRI counts.
About the Author
N. V. Matsiyeuskaya
Grodno State Medical University
Belarus
Belarus
Matsiyeuskaya N.V., MD, PhD, Head of the Department of Infectious Diseases of the educational institution «Grodno State Medical University».
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Review
For citations:
Matsiyeuskaya N.V. The Features of the Course and Outcomes of HIV Infection Diagnosed at the Stage of Pronounced Immunosuppression. Health and Ecology Issues. 2019;(4):16-22. (In Russ.) https://doi.org/10.51523/2708-6011.2019-16-4-3
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