Post-radiation Changes in the Tumor Microenvironment of Endometrioid Adenocarcinoma of the Uterine Body

Abstract

Objective: to reveal the features of PGRMC1 and Galectin-1 expression of the tumor microenvironment of endometrioid adenocarcinoma (EA) of the uterine body exposed to gamma radiation. Mаteriаl аnd methods. The surgical material of 80 female patients was analyzed in this retrospective study. The group of patients undergoing radiotherapy included 42 cases, the group of those who did not included 38 cases. The measurements were made in 10 non-overlapping fields of vision with ×400 magnification. The expression was evaluated separately in the stroma and parenchyma. The comparison of the groups was performed by means of the Mann-Whitney test according to the presented parameters. Results. Statistically significant differences (p < 0.001) were found in the expression of PGRMC1 and Galectin-1 both in the stroma and in EA parenchyma. Conclusion. The obtained data are indicative of the suppression of the secretion of some of the most active promoters of progression in the tumor microenvironment of EA.