ALGORITHM OF RATIONAL ANTIBACTERIAL THERAPY OF PYELONEPHRITIS AND ITS MICROBIOLOGICAL BASIS
https://doi.org/10.51523/2708-6011.2012-9-4-12
Abstract
Aim of research. To study resistance levels to different antibiotics of pyelonephritis etiologic agents, revealing of extended-spectrum beta-lactamases producers among agents and development of an algorithm of microbiological diagnostics and rational antibacterial therapy of pyelonephritis. Materials and methods. A total of 115 clinical strains of enterobacteria (70 - Escherichia coli , 35 - Proteus spp. , 10 - Klebsiella pneumoniae ) isolated from urine of patients with acute and chronic pyelonephritis were included in the research. The sensitivity of microorganisms to antibacterial agents was determined by disc diffusion method. The extended-spectrum beta-lactamases (ESBL) production was carried out by using the double disk diffusion method. The genodetection of ESBL of various groups in etiologic agents of pyelonephritises was determined by means of polymerase chain reaction (PCR). Results. The resistance of microorganisms, etiologic agents of pyelonephritises to antibiotics of various groups was evaluated. The study revealed high prevalence of extended-spectrum β-lactamases producers concerning to CTX-M group. Conclusion. The data obtained during the study about levels and resistance mechanisms of enterobacteria to antibacterial agents of different groups were the base for development of the algorithm of microbiological diagnostics and rational antibacterial therapy of pyelonephritis.
About the Authors
L. V. Lagun
Gomel State Medical University
Belarus
Belarus
D. V. Tapalskiy
Gomel State Medical University
Belarus
Belarus
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Review
For citations:
Lagun L.V., Tapalskiy D.V. ALGORITHM OF RATIONAL ANTIBACTERIAL THERAPY OF PYELONEPHRITIS AND ITS MICROBIOLOGICAL BASIS. Health and Ecology Issues. 2012;(4):62-69. (In Russ.) https://doi.org/10.51523/2708-6011.2012-9-4-12
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