VEGETATIVE REGULATION OF CARDIAL ACTIVITY IN PATIENTS WITH DIFFUSE TOXIC GOITER BEFORE THYROECTOMY

The changes arising in superfluous or insufficient maintenance of thyroid hormones in an organism are known to cause changes of the functional condition of cardiovascular system. The analysis of heart rate variability (HRV) is a modern method to assess the functional condition of cardiac activity and the way how vegetative nervous system influences it at various levels of thyroid hormones. The purpose of this work is to study the features of vegetative regulation of cardiac activity in patients with diffuse toxic goiter (DTG) before thyroectomy. 102 patients with DTG aged from 18 till 55 (average age 43,3 ± 8,2) were examined before the performance of thyroectomy. The examined patients were divided into 3 groups according to the initial thyroid status (hyperthyroidism, euthyroidism, hypothyroidism), the HRV indicators were assessed with analysis of temporary and frequency indicators. Thus, it was established that the DTG patients observed an increase in the average frequency of heart reductions and number of sinus tachycardia episodes regardless of the thyroid status. The DTG patients at a hyperthyroid state before the performance of thyroectomy had a significant decrease in the indicators characterizing the general HRV that pointed to a shift of vegetative balance towards the prevalence of sympathetic section, while there was tension of parasympathetic section. The patients with euthyroid or hyperthyroid condition before the performance of thyroectomy revealed the tension of sympathetic part without any significant changes from parasympathetic part in comparison with healthy people.

вегетативная нервная система, вариабельность сердечного ритма, диффузный токсический зоб, гипертиреоз, эутиреоз, гипотиреоз, vegetative nervous system, variability of a warm rhythm, diffuse toxic goiter, hypothyroidism, hyperthyroidism, euthyroidism

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