APPLICATION OF TAURINE- AND ZINC-BASED COMPOSITIONS TO CORRECT LEAD-ASSOCIATED NEUROACTIVE AMINOACID DYSBALANCE IN HYPOTHALAMUS OF RATS
https://doi.org/10.51523/2708-6011.2012-9-1-26
Abstract
The changes in the levels of neuroactive amino acids in hypothalamus of rats after lead acetate introduction has been shown and the efficacy of taurine- and zinc-based drug compositions to correct the changes has been analyzed. The mixture consisting of taurine and zinc sulfate in a ratio of 4:1 showed the best results.
About the Authors
I. V. Liakh
Grodno State Medical University
Belarus
Belarus
E. M. Doroshenko
Grodno State Medical University
Belarus
Belarus
V. Yu. Smirnov
Grodno State Medical University
Belarus
Belarus
V. M. Sheybak
Grodno State Medical University
Belarus
Belarus
References
1. Лянгузова, И. В. Промышленное загрязнение окружающей среды (краткий обзор проблемы) / И. В. Лянгузова // Проблемы экологии растительных сообществ. - СПб.: ВВМ, 2005. - С. 23-27.
2. Lead-induced developmental perturbations in hippocampal Spl DNA-binding Are prevented by zinc supplementation: in vivo evidence for Pb and Zn competition / M. R. Basha [et al.] // Int. J. Devl. Neuroscience. - 2003. - Vol. 21. - P. 1-12.
3. Satija, N. K. Preventive action of zinc against lead toxicity/ N. K. Satija, A. G. Vij // Indian J. Physiol. Pharmacol. - 1995. - Vol. 39, № 4. - P. 377-382.
4. Cerklewski, F. Influence of dietary zinc on lead toxicity in the rat / F. Cerklewski, R. Forbes // J. Nutr. - 1976. - Vol. 106. - P. 689-696.
5. Rafique, M. Protective effect of zinc over lead toxicity on testes. / M. Rafique, S. Pervez, F. Tahir // J. Coll. Physicians Surg. Pak. - 2010. - Vol. 20, № 6. - P. 377-381.
6. Effects of Zinc Coadministration on Lead Toxicities in Rats / F. Piao [et al.] // Industrial Health. - 2007. - Vol. 45. - P. 546-551.
7. Stoltzfus Efficacy of Iron and/or Zinc Supplementation on Cognitive Performance of Lead-Exposed Mexican Schoolchildren: A Randomized, Placebo-Controlled / J. A. Rico [et al.] // Trial Pediatrics. - 2006. - Vol. 117. - P. 518.
8. Chichovska, M. Study on the influence of L-lysine and zinc administration during exposure to lead and ethanol in rats / M. Chichovska, A. Anguelov // Vet. Arhiv. - 2006. - Vol. 76. - P. 65-73.
9. Antioxidant effect of taurine against lead-induced oxidative stress. Arch Environ Contam / H. Gürer [et al.] // Toxicol. - 2001. -Vol. 41, № 4. - P. 397-402.
10. Shan-Shan, Yu. Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure / Yu Shan-Shan // BMC Developmental Biology. - 2007. - Vol. 7. - P. 51.
11. Protection by a taurinesupplemented diet from lead-induced deficits of long-termpotentiation/depotentiation in dentate gyrus of rats in vivo / D. M. Zhu [et al.] // Neuroscience. - 2005. - Vol. 134, № 1. - P. 215-224.
12. Sturman, J. A. Metabolism of S-taurine in man / J. A. Sturman //J. Nutr. - 1975. - Vol. 105. - P. 1206-1214.
13. Inonue, M. Taurine transport across hepatocyte plasma membranes / M. Inonue, I.M. Arias // J. Biochem. - 1988. - Vol. 104. - P. 155-158.
14. Huxtable, R. Taurine / R. Huxtable, A. Barbeau. - N.Y.: Raven Press, 1976. - 398 p.
15. Selection of Nutrients for Prevention or Amelioration of Lead-Induced Learning and Memory Impairment in Rats / G. Fan [et al.] // Ann. Occup. Hyg. - 2009. - Vol. 53, № 4. - P. 341-351.
Review
For citations:
Liakh I.V., Doroshenko E.M., Smirnov V.Yu., Sheybak V.M. APPLICATION OF TAURINE- AND ZINC-BASED COMPOSITIONS TO CORRECT LEAD-ASSOCIATED NEUROACTIVE AMINOACID DYSBALANCE IN HYPOTHALAMUS OF RATS. Health and Ecology Issues. 2012;(1):130-135. (In Russ.) https://doi.org/10.51523/2708-6011.2012-9-1-26
Views: 379
Email this article 