RECOGNITION ALGORITHM FOR SYSTEMIC INFLAMMATORY RESPONSE SYNDROME IN FEBRILE NEUTROPENIA IN CHILDREN WITH MALIGNANT NEOPLASMS AND HEMOBLASTOSES

Abstract

The sensitivity of procalcitonin (PCT) as a diagnostic test of 68 per cent to detect systemic inflammatory response syndrome (SIRS) was lower than that of C-reactive protein (CRP) (c² = 6,2; р = 0,01). The specificity of both tests to detect and identify SIRS did not substantially differ, which was indicated by the area under curve for CRP - 0,84 and PCT - 0,84. The parallel detection of CRP and PCT in patients with the sings of febrile neutropenia made it possible to identify the patients, who were able to develop the clinic of SIRS within 24-48 hours with probability of 78 per cent and to identify the patients, who did not develop the SIRS clinic within 24-48 hours with probability of 56 per cent.