POLYMORPHISM OF GENE NAT2 AT PATIENTS WITH ULCERATIVE COLITIS AND HEALTHY VOLUNTEERS OF SOUTHEAST POPULATION OF CAUCASIANS OF BELARUS
https://doi.org/10.51523/2708-6011.2010-7-4-9
Abstract
Research objective: to investigate polymorphism of gene NАТ2 at healthy volunteers and patients with ulcerative colitis (UC), to compare conformity between pheno- and genotype and to study association presence between a acetylator genotype and predisposition to development the UC. Materials and research methods: at 30 healthy volunteers of the Gomel region and 46 patients with the UC by means of method PCR-RFLP definition of genotype NAT2 on 5 mononucleotide changes (T341C, G590A, G857A, C282T, C481T) is made. Results of research: comparison acetylator pheno- and genotype in group of healthy volunteers has shown, that mutant alleles took place at any activity N-acetyltransferase (р = 0,08), however presence 4 mononucleotide changes met at a slow acetylator phenotype is more often (р = 0,0007). Comparison of genotypes of healthy volunteers and patients with the UC has shown absence of association of polymorphism of gene NAT2 with predisposition to development of this disease (p > 0,05). Conclusion: polymorphism of gene NAT2 on 5 studied mononucleotide changes is not a marker the UC, but can be used for studying of interrelation with other diseases.
Keywords
NАТ2,
фенотип,
генотип,
полиморфизм,
язвенный колит,
NАТ2,
phenotype,
genotype,
polymorphism,
ulcerative colitis
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Review
For citations:
Satyrova T.V. POLYMORPHISM OF GENE NAT2 AT PATIENTS WITH ULCERATIVE COLITIS AND HEALTHY VOLUNTEERS OF SOUTHEAST POPULATION OF CAUCASIANS OF BELARUS. Health and Ecology Issues. 2010;(4):48-53. (In Russ.) https://doi.org/10.51523/2708-6011.2010-7-4-9
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